| Tag | Content |
|---|---|
| Uniprot ID | A0A0G2K1E2 |
| Entrez ID | 315346 |
| Genbank protein ID | EDL86784.1 |
| Genbank nucleotide ID | NM_001108118.1 |
| Ensembl protein ID | ENSRNOP00000071805 |
| Ensembl nucleotide ID | ENSRNOG00000057451 |
| Gene name | Integrin alpha 5 (Mapped) |
| Gene symbol | Itga5 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MPPRQPTRRP GGGPSRELGK LLPALSHSPL GGLGSGSGSV APGQGRTGAM GSWTPRSPRS 60 PLHAVLLRWG PRRLPPLLPL LLLLWPPPLQ VGGFNLDAEA PAVLSGPPGS LFGFSVEFYR 120 PGRDGVSVLV GAPKANTSQP GVLQGGAVYV CPWGTSPIQC STIQFDSKGS RILESSLYSE 180 EPVEYKSLQW FGATVRAHGS SILACAPLYS WRTEKDPQND PVGTCYLSTE NFTRILEYAP 240 CRSDFGSAAG QGYCQGGFSA EFTKTGRVVL GGPGSYFWQG QILSATQEQI SESYYPQYLI 300 NPVQGQLQTR QASSVYDDSY LGYSVAVGEF SGDDTEDFVA GVPKGNLTYG YVTVLNGSDI 360 HSLYNVSGEQ MASYFGYAVA ATDTNGDGLD DLLVGAPLLM ERTADGRPQE VGRVYIYLQH 420 PEGIEPTPSL TLTGQDEFGR FGSSLTPLGD LDQDGYNDVA IGAPFGGEAQ QGVVFIFPGG 480 PGGLNTKPSQ VLQPLWAAGH TPDFFGSALR GGRDLDGNGY PDLIVGSFGV DKALVYRGRP 540 IISASASLTI FPSMFNPEER SCSLEGNPVS CINLSFCLNA SGKHVPNSIG FEVELQLDWQ 600 KQKGGVRRAL FLASKQATLT QTLLIQNGAR EDCREMKIYL RNESEFRDKL SPIHIALNFS 660 LDPKAPMDSH GLRPVLHYQS KSRIEDKAQI LLDCGEDNIC VPDLQLAVYG EKKHVYLGDK 720 NALNLTFLAQ NLGEGGAYEA ELRVTAPLEA EYSGLVRHPG NFSSLSCDYF AVNQSRQLVC 780 DLGNPMKAGT SIWGGLRFTV PHLQDTKKTI QFDFQILSKN LNNSQSNMVS FPLSVEAQAQ 840 VSLNGVSKPE AVIFPVSDWN PQDQPQKEGD LGPAVHHVYE LINQGPSSIS QGVLEISCPQ 900 ALEGQQLLYV TKVTGLNNCT SNYTPNSQGL ELDPEVSPHH LQRREAPGRS STTSGTQVLK 960 CPEAKCFRLR CEFGPLHRQE SRSLQLHFRV WAKTFLQQEY QPFSLQCEAL YEALKMPYQI 1020 LPRQLPQKKL QVATAVQWTK AEGSNGVPLW IIILAILFGL LLLGLLIYVL YKLGFFKRSL 1080 PYGTAMEKAQ LKPPATSDA 1099 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ITGA5 | 486493 | F1PY05 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ITGA5 | A0A452ELS6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ITGA5 | 3678 | P08648 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Itga5 | 16402 | P11688 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ITGA5 | A0A2I3RVI9 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ITGA5 | 100155091 | F1SR53 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Itga5 | 315346 | A0A0G2K1E2 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0005911 | cell-cell junction |
| GO:0005737 | cytoplasm |
| GO:0031410 | cytoplasmic vesicle |
| GO:0005783 | endoplasmic reticulum |
| GO:0009897 | external side of plasma membrane |
| GO:0005615 | extracellular space |
| GO:0005925 | focal adhesion |
| GO:0005794 | Golgi apparatus |
| GO:0016021 | integral component of membrane |
| GO:0034674 | integrin alpha5-beta1 complex |
| GO:0008305 | integrin complex |
| GO:0005886 | plasma membrane |
| GO:0032587 | ruffle membrane |
| GO:0045202 | synapse |
| GO:0050839 | cell adhesion molecule binding |
| GO:0005154 | epidermal growth factor receptor binding |
| GO:0005178 | integrin binding |
| GO:0038023 | signaling receptor activity |
| GO:0023035 | CD40 signaling pathway |
| GO:0007155 | cell adhesion |
| GO:0033627 | cell adhesion mediated by integrin |
| GO:0033631 | cell-cell adhesion mediated by integrin |
| GO:0031589 | cell-substrate adhesion |
| GO:0007044 | cell-substrate junction assembly |
| GO:0035987 | endodermal cell differentiation |
| GO:0007565 | female pregnancy |
| GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
| GO:0034113 | heterotypic cell-cell adhesion |
| GO:0007229 | integrin-mediated signaling pathway |
| GO:0007159 | leukocyte cell-cell adhesion |
| GO:0007613 | memory |
| GO:2000811 | negative regulation of anoikis |
| GO:0030335 | positive regulation of cell migration |
| GO:0010811 | positive regulation of cell-substrate adhesion |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| GO:1903672 | positive regulation of sprouting angiogenesis |
| GO:0045765 | regulation of angiogenesis |
| GO:0035313 | wound healing, spreading of epidermal cells |