| Tag | Content |
|---|---|
| Uniprot ID | F1PY05 |
| Entrez ID | 486493 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005636739.2 |
| Ensembl protein ID | ENSCAFP00000009742 |
| Ensembl nucleotide ID | ENSCAFG00000006491 |
| Gene name | Integrin subunit alpha 5 |
| Gene symbol | ITGA5 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MRGAGLPEGA AGARGPRGRP APPLPLLPLL LLLLLPPPPR AAGFNLDAQA PAVLSGPPRS 60 FFGFAVDFYR PGARGVSVLV GAPKANTSQP GVLQGGAVYL CPWGAGRGHC TPIEFDSKGS 120 RVLESSVSSP DGEEPVEYKS LQWFGATVRA HGSSILACAP LYSWRTEKEP LSDPVGTCYL 180 STDNFTRILE YAPCRSDFSW AAGQGYCQGG FSAEFTKTGR VVLGGPGSYF WQGQILSATQ 240 EQIAESYYPE YLINLVQGQL QTRQASSIYD DSYLGYSVAV GEFSGDDTED FVAGVPKGNL 300 TYGYVTILNG SDIRSLYNFS GEQMASYFGY AVAATDTNGD GLDDLLVGAP LLMERTADGR 360 PQEVGRVYIY LQHPAGMEPT PTLTLTGQDE FGRFGSSLTP LGDLDQDGYN DIAIGAPFGG 420 ETQQGVVLIF PGGPGGPGSQ PSQVLLPLWA AGHTPHFFGS ALRGGRDLDG NGYPDLIVGS 480 FGVDKAVVYR GRPIVSTSAS LTIFPAMFNP EERSCSLEGN PVACINLSFC LNASGKHVPD 540 SIGFTVELQL DWQKQKGGVR RALFLASRQA TLTQTLLIQN GAREDCREMK VYLRNESEFR 600 DKLSPIHIAL NFSLDPQAPV DAHGLRPVLH YQSKSRIEDK AQILLDCGED NICVPDLQLE 660 VFGDQNHVYL GDKNSLNLTF HAQNVGEGGA YEAELRVTAP PEAEYSGLVR NPGNFSSLSC 720 DYFAVNQSRL LVCDLGNPMK AGASIWGGLR FTVPHLRDTK KTIQFDFQIL SKNLNNSQSE 780 VVSFPLSVEA SAQVSLNGVS KPEAVLFPAS DWRPREQPQE EGDVGPAVQH VYELINQGPS 840 SISRGVLELS CPRTLEGQQL LYVTRVEGLS NCTSSHPPNP ESLELDPEGP QHHRLQRREA 900 PGRGPGSSGP QILKCPEAEC FRLRCELGPL HRQESRSLQL HFRVWAKTFL QREHQPFSLQ 960 CEAVYEALRM PYRILPQQLP RRELQVATAV QWTKAEGSHG VPLWIIILAI LVGLLLLGLL 1020 IYILYKLGFF KRSLPYGTAM EKAQLKPPAT SDA 1053 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ITGA5 | 486493 | F1PY05 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ITGA5 | A0A452ELS6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ITGA5 | 3678 | P08648 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Itga5 | 16402 | P11688 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ITGA5 | A0A2I3RVI9 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ITGA5 | 100155091 | F1SR53 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Itga5 | 315346 | A0A0G2K1E2 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005911 | cell-cell junction |
| GO:0031410 | cytoplasmic vesicle |
| GO:0005783 | endoplasmic reticulum |
| GO:0009897 | external side of plasma membrane |
| GO:0005925 | focal adhesion |
| GO:0005794 | Golgi apparatus |
| GO:0034674 | integrin alpha5-beta1 complex |
| GO:0032587 | ruffle membrane |
| GO:0045202 | synapse |
| GO:0005178 | integrin binding |
| GO:0023035 | CD40 signaling pathway |
| GO:0033631 | cell-cell adhesion mediated by integrin |
| GO:0031589 | cell-substrate adhesion |
| GO:0007044 | cell-substrate junction assembly |
| GO:0035987 | endodermal cell differentiation |
| GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
| GO:0034113 | heterotypic cell-cell adhesion |
| GO:0007229 | integrin-mediated signaling pathway |
| GO:0007159 | leukocyte cell-cell adhesion |
| GO:0007613 | memory |
| GO:2000811 | negative regulation of anoikis |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| GO:1903672 | positive regulation of sprouting angiogenesis |
| GO:0035313 | wound healing, spreading of epidermal cells |