Gene: ITGA5

Basic information

Tag Content
Uniprot ID A0A2I3RVI9
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSPTRP00000068708
Ensembl nucleotide ID ENSPTRG00000005040
Gene name Integrin subunit alpha 5
Gene symbol ITGA5
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MGSRTPESPL HAVQLRWGPR RRPPLLPLLL LLLPPPPRVG GFNLDAEAPA VLSGPPGSFF 60
GFSVEFYRPG TDGVSVLVGA PKANTSQPGV LQGGAVYLCP WGASPTQCTP IEFDSKGSRL 120
LESSLSSSEG EEPVEYKSLQ WFGATVRAHG SSILACAPLY SWRTEKEPLS DPVGTCYLST 180
DNFTRILEYA PCRSDFSWAA GQGYCQGGFS AEFTKTGRVV LGGPGSYFWQ GQILSATQEQ 240
IAESYYPEYL INLVQGQLQT RQASSIYDDS YLGESQLSLL FADFVAGVPK GNLTYGYVTI 300
LNGSDIRSLY NFSGEQMASY FGYAVAATDI NGDGLDDLLV GAPLLMDRTP DGRPQEVGRV 360
YVYLQHPAGI EPTPTLTLTG HDEFGRFGSS LTPLGDLDQD GYNDVAIGAP FGGETQQGVV 420
FVFPGGPGGL GSKPSQVLQP LWAASHTPDF FGSALRGGRD LDGNGYPGDP NSIDPTFTLG 480
RGRPIVSASA SLTIFPAMFN PEERSCSLEG NPVACINLSF CLNASGKHVA DSIGFTVELQ 540
LDWQKQKGGV RRALFLASRQ ATLTQTLLIQ NGAREDCREM KIYLRNESEF RDKLSPIHIA 600
LNFSLDPQAP VDSHGLRPAL HYQSKSRIED KAQILLDCGE DNICVPDLQL EVFGEQNHVY 660
LGDKNALNLT FHAQNVGEGG AYEAELRVTA PPEAEYSGLV RHPGNFSSLS CDYFAVNQSR 720
LLVCDLGNPM KAGASLWGGL RFTVPHLRDT KKTIQFDFQI LSKNLNNSQS DVVSFRLSVE 780
AQAQVTLNGV SKPEAVLFPV SDWHPRDQPQ KEEDLGPAVH HVYELINQGP SSISQGVLEL 840
SCPQALEGQQ LLYVTRVTGL NCTTNHPINP KGLELDPEGS LHHQQKREAP SRSSASSGPQ 900
ILKCPEAECF RLRCELGPLH QQESQSLQLH FRVWAKTFLQ REHQPFSLQC EAVYKALKMP 960
YRILPRQLPQ KERQVATAVQ WTKAEGSYGI PLWIIILAIL FGLLLLGLLI YILYKLGFFK 1020
RSLPYGTAME KAQLKPPATS DA 1042

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologITGA5486493F1PY05Canis lupus familiarisPredictionMore>>
1:1 orthologITGA5A0A452ELS6Capra hircusPredictionMore>>
1:1 orthologITGA53678P08648Homo sapiensPredictionMore>>
1:1 orthologItga516402P11688CPOMus musculusPublicationMore>>
1:1 orthologITGA5A0A2I3RVI9Pan troglodytesPredictionMore>>
1:1 orthologITGA5100155091F1SR53Sus scrofaPredictionMore>>
1:1 orthologItga5315346A0A0G2K1E2Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0008305 integrin complex
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0130 Cell adhesion
KW-0401 Integrin
KW-0472 Membrane
KW-0675 Receptor
KW-1185 Reference proteome
KW-0677 Repeat
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf

PROSITE

PROSITE ID PROSITE Term
PS51470 FG_GAP
PS00242 INTEGRIN_ALPHA

Pfam

Pfam ID Pfam Term
PF01839 FG-GAP
PF08441 Integrin_alpha2