| Tag | Content |
|---|---|
| Uniprot ID | P11688; E9QN40; |
| Entrez ID | 16402 |
| Genbank protein ID | CAA33273.1; CAA55638.1; |
| Genbank nucleotide ID | NM_010577.4 |
| Ensembl protein ID | ENSMUSP00000023128 |
| Ensembl nucleotide ID | ENSMUSG00000000555 |
| Gene name | Integrin alpha-5 |
| Gene symbol | Itga5 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 25670798; 25242040; |
| Functional description | Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity). |
| Sequence | MGSWTPRSPR SPLHAVLLRW GPRRLPPLLP LLLLLWPPPL QVGGFNLDAE APAVLSGPPG 60 SLFGFSVEFY RPGRDGVSVL VGAPKANTSQ PGVLQGGAVY VCPWGTSPIQ CTTIQFDSKG 120 SRILESSLYS AKGEEPVEYK SLQWFGATVR AHGSSILACA PLYSWRTEKD PQNDPVGTCY 180 LSTENFTRIL EYAPCRSDFG SAAGQGYCQG GFSAEFTKTG RVVLGGPGSY FWQGQILSAT 240 QEQISESYYP EYLINPVQGQ LQTRQASSVY DDSYLGYSVA VGEFSGDDTE DFVAGVPKGN 300 LTYGYVTVLN GSDIHSLYNV SGEQMASYFG YAVAATDTNG DGLDDLLVGA PLLMERTADG 360 RPQEVGRVYI YLQRPAGIDP TPTLTLTGQD EFSRFGSSLT PLGDLDQDGY NDVAIGAPFG 420 GEAQQGVVFI FPGGPGGLST KPSQVLQPLW AAGRTPDFFG SALRGGRDLD GNGYPDLIVG 480 SFGVDKALVY RGRPIISASA SLTIFPSMFN PEERSCSLEG NPVSCINLSF CLNASGKHVP 540 NSIGFEVELQ LDWQKQKGGV RRALFLTSKQ ATLTQTLLIQ NGAREDCREM KIYLRNESEF 600 RDKLSPIHIA LNFSLDPKAP MDSHGLRPVL HYQSKSRIED KAQILLDCGE DNICVPDLQL 660 DVYGEKKHVY LGDKNALNLT FHAQNLGEGG AYEAELRVTA PLEAEYSGLV RHPGNFSSLS 720 CDYFAVNQSR QLVCDLGNPM KAGTSLWGGL RFTVPHLQDT KKTIQFDFQI LSKNLNNSQS 780 NVVSFPLSVE AQAQVSLNGV SKPEAVIFPV SDWNPQDQPQ KEEDLGPAVH HVYELINQGP 840 SSISQGVLEL SCPQALEGQQ LLYVTKVTGL SNCTSNYTPN SQGLELDPET SPHHLQKREA 900 PGRSSTASGT QVLKCPEAKC FRLRCEFGPL HRQESRSLQL HFRVWAKTFL QREYQPFSLQ 960 CEAVYEALKM PYQILPRQLP QKKLQVATAV QWTKAEGSNG VPLWIIILAI LFGLLLLGLL 1020 IYVLYKLGFF KRSLPYGTAM EKAQLKPPAT SDA 1053 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ITGA5 | 486493 | F1PY05 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ITGA5 | A0A452ELS6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ITGA5 | 3678 | P08648 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Itga5 | 16402 | P11688 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ITGA5 | A0A2I3RVI9 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ITGA5 | 100155091 | F1SR53 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Itga5 | 315346 | A0A0G2K1E2 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005154 | epidermal growth factor receptor binding | ISO |
| GO:0005178 | integrin binding | ISO |
| GO:0005178 | integrin binding | IPI |
| GO:0005515 | protein binding | IPI |
| GO:0046872 | metal ion binding | IEA |
| GO:0050839 | cell adhesion molecule binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0007044 | cell-substrate junction assembly | IDA |
| GO:0007155 | cell adhesion | ISO |
| GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | IMP |
| GO:0007159 | leukocyte cell-cell adhesion | IMP |
| GO:0007229 | integrin-mediated signaling pathway | ISO |
| GO:0007565 | female pregnancy | IEA |
| GO:0007613 | memory | IMP |
| GO:0010811 | positive regulation of cell-substrate adhesion | ISO |
| GO:0023035 | CD40 signaling pathway | ISO |
| GO:0030335 | positive regulation of cell migration | ISO |
| GO:0031589 | cell-substrate adhesion | ISO |
| GO:0033627 | cell adhesion mediated by integrin | ISS |
| GO:0033627 | cell adhesion mediated by integrin | ISO |
| GO:0033631 | cell-cell adhesion mediated by integrin | IMP |
| GO:0034113 | heterotypic cell-cell adhesion | ISO |
| GO:0035313 | wound healing, spreading of epidermal cells | IEA |
| GO:0035987 | endodermal cell differentiation | ISO |
| GO:0045765 | regulation of angiogenesis | IGI |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | ISO |
| GO:1903672 | positive regulation of sprouting angiogenesis | ISO |
| GO:2000811 | negative regulation of anoikis | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005737 | cytoplasm | ISO |
| GO:0005783 | endoplasmic reticulum | IDA |
| GO:0005794 | Golgi apparatus | IDA |
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IDA |
| GO:0005925 | focal adhesion | ISS |
| GO:0005925 | focal adhesion | ISO |
| GO:0008305 | integrin complex | ISO |
| GO:0009897 | external side of plasma membrane | IDA |
| GO:0009986 | cell surface | ISS |
| GO:0009986 | cell surface | ISO |
| GO:0009986 | cell surface | IDA |
| GO:0031410 | cytoplasmic vesicle | IDA |
| GO:0034674 | integrin alpha5-beta1 complex | ISO |
| GO:0045202 | synapse | IDA |
| GO:0005911 | cell-cell junction | ISO |
| GO:0032587 | ruffle membrane | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-109582 | Hemostasis | IEA |
| R-MMU-1266738 | Developmental Biology | IEA |
| R-MMU-1474244 | Extracellular matrix organization | IEA |
| R-MMU-1566948 | Elastic fibre formation | IEA |
| R-MMU-1566977 | Fibronectin matrix formation | IEA |
| R-MMU-202733 | Cell surface interactions at the vascular wall | IEA |
| R-MMU-216083 | Integrin cell surface interactions | IEA |
| R-MMU-373760 | L1CAM interactions | IEA |
| R-MMU-422475 | Axon guidance | IEA |
| R-MMU-445144 | Signal transduction by L1 | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0106 | Calcium |
| KW-0130 | Cell adhesion |
| KW-0965 | Cell junction |
| KW-0165 | Cleavage on pair of basic residues |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0401 | Integrin |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |