Gene: ALX4

Basic information

Tag Content
Uniprot ID A0A287A150
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSSSCP00000037650
Ensembl nucleotide ID ENSSSCG00000040329
Gene name ALX homeobox 4
Gene symbol ALX4
Organism Sus scrofa
NCBI taxa ID 9823
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MNAETCVSYC ESPAAAMDAY YSPVSQSREG SSPFRAYPGG DKFSTTFLSA AAKGQGFGDA 60
KNRARYGAGQ QDLAAPLESG AGARGSFNKF QPQPQPPAPQ PPPQPQPQPQ PQPPAQQPHL 120
YLPRGACKTP PDGSLKLQEG GGGHNAALQV PCYAKESSLG EPELPPDSDT VGMDSSYLSV 180
KEAGVKGPQD RASADLPSPL EKADSESNKG KKRRNRTTFT SYQLEELEKV FQKTHYPDVY 240
AREQLAMRTD LTEARVQVWF QNRRAKWRKR ERFGQMQQVR THFSTAYELP LLTRAENYAQ 300
IQNPSWIGNN GAASPVPACV VPCDPVPACM SPHAHPPGSG ATDFLSVSGA GSHVGQTHMG 360
SLFGAAGLSP GLNGYELNGE PDRKTSSIAA LRMKAKEHSA AISWAT 406

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologALX4609979E2RLA0Canis lupus familiarisPredictionMore>>
1:1 orthologALX4A0A452E379Capra hircusPredictionMore>>
1:1 orthologALX460529Q9H161Homo sapiensPredictionMore>>
1:1 orthologAlx411695O35137CPOE14.5Mus musculusPublicationMore>>
1:1 orthologALX4H2Q3G4Pan troglodytesPredictionMore>>
1:1 orthologALX4A0A287A150Sus scrofaPredictionMore>>
1:1 orthologALX4100347124G1SSX0Oryctolagus cuniculusPredictionMore>>
1:1 orthologAlx4296511D3ZEM1Rattus norvegicusPredictionMore>>
1:1 orthologalx4a100006399E7FGP3Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005654 nucleoplasm
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0071837 HMG box domain binding
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0009952 anterior/posterior pattern specification
GO:0048565 digestive tract development
GO:0042733 embryonic digit morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0001942 hair follicle development
GO:0007517 muscle organ development
GO:0009791 post-embryonic development
GO:0042981 regulation of apoptotic process
GO:0060021 roof of mouth development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR033203 ALX4
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003654 OAR_dom

PROSITE

PROSITE ID PROSITE Term
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2
PS50803 OAR

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain
PF03826 OAR