Gene: ALX4

Basic information

Tag Content
Uniprot ID H2Q3G4
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSPTRP00000006127
Ensembl nucleotide ID ENSPTRG00000003529
Gene name ALX homeobox 4
Gene symbol ALX4
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MNAETCVSYC ESPAAAMDAY YSPVSQSREG SSPFRAFPGG DKFGTTFLSA AAKAQGFGDA 60
KSRARYGAGQ QDLATPLESG AAPQQQQPQP QPPAQPHLYL QRGACKTPPD GSLKLQEGSS 120
GHSAALQVPC YAKESSLGEP ELPPDSDTVG MDSSYLSVKE AGVKGPQDRA SSDLPSPLEK 180
ADSESNKGKK RRNRTTFTSY QLEELEKVFQ KTHYPDVYAR EQLAMRTDLT EARVQVWFQN 240
RRAKWRKRER FGQMQQVRTH FSTAYELPLL TRAENYAQIQ NPSWLGNNGA ASPVPACVVP 300
CDPVPACMSP HAHPPGSGAS SVTDFLSVSG AGSHVGQTHM GSLFGAASLS PGLNGYELNG 360
EPDRKTSSIA ALRMKAKEHS AAISWAT 387

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologALX4609979E2RLA0Canis lupus familiarisPredictionMore>>
1:1 orthologALX4A0A452E379Capra hircusPredictionMore>>
1:1 orthologALX460529Q9H161Homo sapiensPredictionMore>>
1:1 orthologAlx411695O35137CPOE14.5Mus musculusPublicationMore>>
1:1 orthologALX4H2Q3G4Pan troglodytesPredictionMore>>
1:1 orthologALX4A0A287A150Sus scrofaPredictionMore>>
1:1 orthologALX4100347124G1SSX0Oryctolagus cuniculusPredictionMore>>
1:1 orthologAlx4296511D3ZEM1Rattus norvegicusPredictionMore>>
1:1 orthologalx4a100006399E7FGP3Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005634 nucleus
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0007275 multicellular organism development
GO:0006357 regulation of transcription by RNA polymerase II

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR033203 ALX4
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003654 OAR_dom

PROSITE

PROSITE ID PROSITE Term
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2
PS50803 OAR

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain
PF03826 OAR