| Tag | Content |
|---|---|
| Uniprot ID | D3ZEM1 |
| Entrez ID | 296511 |
| Genbank protein ID | EDL79594.1 |
| Genbank nucleotide ID | NM_001106553.1 |
| Ensembl protein ID | ENSRNOP00000000009 |
| Ensembl nucleotide ID | ENSRNOG00000000008 |
| Gene name | ALX homeobox 4 |
| Gene symbol | Alx4 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MNAETCVSYC ESPATAMDAY YSPVSQSREG SSPFRGFPGG DKFGTTFLSA AAKGQGFGDA 60 KGRARYGAGQ QDLAAPLESN AGARGSFNKF QPQPPTPQPP PAPPAPPAHL YLQRGACKTP 120 PDGSLKLQEG SGGHNAALQV PCYAKESNLG EPELPPDSEP VGMDNSYLSV KETGAKGPQD 180 RAGAEIPSPL EKTDSESSKG KKRRNRTTFT SYQLEELEKV FQKTHYPDVY AREQLAMRTD 240 LTEARVQVWF QNRRAKWRKR ERFGQMQQVR THFSTAYELP LLTRAENYAQ IQNPSWIGNN 300 GAASPVPACV VPCDPVPACM SPHAHPPGSG ASSVSDFLSV SGAGSHVGQT HMGSLFGAAG 360 ISPGLNGYEM NGEPDRKTSS IAALRMKAKE HSAAISWAT 399 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ALX4 | 609979 | E2RLA0 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ALX4 | A0A452E379 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ALX4 | 60529 | Q9H161 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Alx4 | 11695 | O35137 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | ALX4 | H2Q3G4 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ALX4 | A0A287A150 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | ALX4 | 100347124 | G1SSX0 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Alx4 | 296511 | D3ZEM1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | alx4a | 100006399 | E7FGP3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0071837 | HMG box domain binding |
| GO:0046982 | protein heterodimerization activity |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0048565 | digestive tract development |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0035115 | embryonic forelimb morphogenesis |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0001942 | hair follicle development |
| GO:0035108 | limb morphogenesis |
| GO:0007517 | muscle organ development |
| GO:0007389 | pattern specification process |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0009791 | post-embryonic development |
| GO:0042981 | regulation of apoptotic process |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| GO:0060021 | roof of mouth development |
| GO:0048705 | skeletal system morphogenesis |