| Tag | Content |
|---|---|
| Uniprot ID | A0A287ABQ3 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSSSCP00000041398 |
| Ensembl nucleotide ID | ENSSSCG00000007252 |
| Gene name | DNA methyltransferase 3 beta |
| Gene symbol | DNMT3B |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MKGDTRQLNG EEDASRREDS IITNGGCSDQ SSDSKDAPSP PILEAISTPE IRGRRSSSRL 60 SKREVSSLLS YTQDLTGDGD GEGEDGDGSD TPVMPKLFRE TRTRSESPAV RTRNNNSTSS 120 RERHRPSPRA TRGRQGRHHV DESPVEFSAT RSLRRRTASS AGTPWPSPAS PYLTIDLTED 180 DVVPQSSSTP YGRLAQDSQQ ESMESPQVDT EDRDADSSEY QDGKEFGIGD LVWGKIKGFS 240 WWPAMVVSWK ATSKRQAMAG MRWVQWFGDG KFSEIPADKL VALGLFSHHF NLATFNKLVS 300 YRKAMYHALE KARIRAGKTF PSNPGDSMED QLKPMLEWAH GGFKPTGVEG LKPNNKQPVV 360 NKSKVRRTGS RSVEARKHES KTRRRTADDS ATSDYCPPPK RLKTNCYNNG KDRGDEDQSR 420 EQMASDVTNN KSSLEDSCLS CGRKNPVSFH PLFEGGLCQT CRDRFLELFY MYDDDGYQSY 480 CTVCCEGREL LLCSNTSCCR CFCVECLEVL VGAGTAADAK LQEPWSCYMC LPQRCHGVLR 540 RRKDWSVRLQ AFFTSDPGLE YEAPKLYPAI PANRRRPIRV LSLFDGIATG YLVLKELGIK 600 VEKYVASEVC EESIAVGTVK HEGNIKYVND VRNITKKNIE EWGPFDLVIG GSPCNDLSNV 660 NPARKGLYEG TGRLFFEFYH LLNYTRPKEG DDRPFFWMFE NVVAMKVGDK RDISRFLECN 720 PVMIDAIKVS AAHRARYFWG NLPGMNRPVI ASKNDKLELQ DCLEFNRTAK LKKVQTITTK 780 SNSIRQGKNQ LFPVVMNGKE DVLWCTELER IFGFPVHYTD VSNMGRVARQ KLLGRSWSVP 840 VIRHLFAPLK DYFACE 856 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DNMT3B | A0A452DST5 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | DNMT3B | 1789 | Q9UBC3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Dnmt3b | 13436 | O88509 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | DNMT3B | 458174 | A0A2I3SYU8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DNMT3B | A0A287ABQ3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dnmt3b | 444985 | Q1LZ51 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dnmt3bb.1 | 317744 | Q588C6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005654 | nucleoplasm |
| GO:0003886 | DNA (cytosine-5-)-methyltransferase activity |
| GO:0003714 | transcription corepressor activity |
| GO:0051573 | negative regulation of histone H3-K9 methylation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0010628 | positive regulation of gene expression |
| GO:0051571 | positive regulation of histone H3-K4 methylation |