| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3SYU8; A0A2J8PYU8; |
| Entrez ID | 458174 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_514580.6 |
| Ensembl protein ID | ENSPTRP00000082164 |
| Ensembl nucleotide ID | ENSPTRG00000013384 |
| Gene name | DNA methyltransferase 3 beta |
| Gene symbol | DNMT3B |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MKGDTRHLNG EEDAGGREDS ILVNGACSDQ SSDSPPILEA IRTPEIRGRR SSSRLSKREV 60 SSLLSYTQDL TGDGDGEDGD GSDTPVMPKL FRETRTRSES PAVRTRNNNS VSSRERHRPS 120 PRSTRGRQGR NHVDESPVEF PATRSLRRRA TASAGTPWPS PPSSYLTIDL TDDTEDTHGT 180 PQSSSTPYAR LAQDSQQGGM ESPQVEADSG DGDSSEYQDG KEFGIGDLVW GKIKGFSWWP 240 AMVVSWKATS KRQAMSGMRW VQWFGDGKFS EVSADKLVAL GLFSQHFNLA TFNKLVSYRK 300 AMYHALEKAR VRAGKTFPSS PGDSLEDQLK PMLEWAHGGF KPTGIEGLKP NNTQPVVNKS 360 KVRRAGSRKL ESRKYENKTR RRTADDSATS DYCPAPKRLK TNCYNNGKDR GDEDQSREQM 420 ASDVANNKSS LEDGCLSCGR KNPVSFHPLF EGGLCQTCRD RFLELFYMYD DDGYQSYCTV 480 CCEGRELLLC SNTSCCRCFC VECLEVLVGT GTAAEAKLQE PWSCYMCLPQ RCHGVLRRRK 540 DWNVRLQAFF TSDTGLEYEA PKLYPAIPAA RRRPIRVLSL FDGIATGYLV LKELGIKVGK 600 YVASEVCEES IAVGTVKHEG NIKYVNDVRN ITKKNIEEWG PFDLVIGGSP CNDLSNVNPA 660 RKGLYEGTGR LFFEFYHLLN YSRPKEGDDR PFFWMFENVV AMKVGDKRDI SRFLECNPVM 720 IDAIKVSAAH RARYFWGNLP GMNRPVIASK NDKLELQDCL EYNRIAKLKK VQTITTKSNS 780 IKQGKNQLFP VVMNGKEDVL WCTELERIFG FPVHYTDVSN MGRGARQKLL GRSWSVPVIR 840 HLFAPLKDYF ACE 853 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DNMT3B | A0A452DST5 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | DNMT3B | 1789 | Q9UBC3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Dnmt3b | 13436 | O88509 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | DNMT3B | 458174 | A0A2I3SYU8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DNMT3B | A0A287ABQ3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dnmt3b | 444985 | Q1LZ51 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dnmt3bb.1 | 317744 | Q588C6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005654 | nucleoplasm |
| GO:0003886 | DNA (cytosine-5-)-methyltransferase activity |
| GO:0003714 | transcription corepressor activity |
| GO:0051573 | negative regulation of histone H3-K9 methylation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0010628 | positive regulation of gene expression |
| GO:0051571 | positive regulation of histone H3-K4 methylation |