Gene: DNMT3B

Basic information

Tag Content
Uniprot ID A0A452DST5
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSCHIP00000002762
Ensembl nucleotide ID ENSCHIG00000006391
Gene name Uncharacterized protein
Gene symbol DNMT3B
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MKADTRQLNG EEDASRREDS ILTNGGCSDQ SSDSKDAPSP PILEAIGTPE IRGGRGGRGG 60
VDLTGDGYGE GEDGDGSDTP VMPKLFRETR TRSESPAVRT RNNSSTSNRE RHRPSPRSTR 120
GRQGRSHVDE SPVEFSTTRS LRRRTGSSAG TPWPSPANED VVPQGSSTPY ARLAQDSQQE 180
SMESSQLDVE GRDADSTEYQ DGKEFGIGDL VWGKIKGFSW WPAMVVSWKA TSKRQAMSGM 240
RWVQWFGDGK FSEIPADKLV ALGLFSQHFN LATFNKLVSY RKAMYHALEK ARIRAGKTFP 300
SSPGDSLEDQ LKPMLEWAHG GFKPTGVEGL KPNNKQPVVN KSKVRRTGSR NLEARKHENK 360
TRRRTADDSA TSDYCPPPKR LKTNCYNNGK DRGEEDQSRE QMASDVASNK GNLEDSCLSC 420
GRKNPVSFHP LFEGGLCQTC RDRFLELFYM YDDDGYQSYC TVCCEGRELL LCSNTSCCRC 480
FCVECLEALV GTGTAAEAKL QEPWSCYMCL PQRCHGILRR RKDWSVRLQA FFTSDPGLEY 540
EAPKLYPAIP ANRRRPIRVL SLFDGIATGY LVLKELGIKV EKYVASEVCE ESIAVGTVKH 600
EGNIKYVNDV RNITKKNIEE WGPFDLVIGG SPCNDLSNVN PARKGLYEGT GRLFFEFYHL 660
LNYTRPKEGE DRPFFWMFEN VVAMKVGDKR DISRFLECNP VMIDAIKVSA AHRARYFWGN 720
LPGMNRPVIA SKNDKLELQD CLEFNRTAKL KKVQTITTKS NSIRQGKNQL FPVVMNGKED 780
VLWCTELERI FGFPVHYTDV SNMGRVARQK LLGRSWSVPV IRHLFAPLKD YFACE 835

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologDNMT3BA0A452DST5Capra hircusPredictionMore>>
1:1 orthologDNMT3B1789Q9UBC3Homo sapiensPredictionMore>>
1:1 orthologDnmt3b13436O88509CPOE14.5Mus musculusPublicationMore>>
1:1 orthologDNMT3B458174A0A2I3SYU8Pan troglodytesPredictionMore>>
1:1 orthologDNMT3BA0A287ABQ3Sus scrofaPredictionMore>>
1:1 orthologDnmt3b444985Q1LZ51Rattus norvegicusPredictionMore>>
1:1 orthologdnmt3bb.1317744Q588C6Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0009008 DNA-methyltransferase activity
GO:0010468 regulation of gene expression

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0489 Methyltransferase
KW-1185 Reference proteome
KW-0949 S-adenosyl-L-methionine
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR025766 ADD
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR040552 DNMT3_ADD
IPR030488 DNMT3B_ADD
IPR000313 PWWP_dom
IPR029063 SAM-dependent_MTases
IPR011011 Znf_FYVE_PHD

PROSITE

PROSITE ID PROSITE Term
PS51533 ADD
PS00094 C5_MTASE_1
PS50812 PWWP
PS51679 SAM_MT_C5

Pfam

Pfam ID Pfam Term
PF17980 ADD_DNMT3
PF00145 DNA_methylase
PF00855 PWWP