| Tag | Content |
|---|---|
| Uniprot ID | Q1LZ51; F1LQ40; |
| Entrez ID | 444985 |
| Genbank protein ID | EDL85992.1; CAE52319.1; |
| Genbank nucleotide ID | NM_001003959.1 |
| Ensembl protein ID | ENSRNOP00000015482 |
| Ensembl nucleotide ID | ENSRNOG00000010625 |
| Gene name | DNA methyltransferase 3 beta |
| Gene symbol | Dnmt3b |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MKGDSRHLNE EEGASGYEDC IIVNGNCSDQ SSDTKDAPSP PVLEAICTEP VCTPETRGRR 60 SSSRLSKREV SSLLNYTQDV VGDGDGEADD GDGSDILMMP KLTRETKDAR TPSESPAVRT 120 RNSNSISSLE RQRTSPRITR GRQGRYHVQE YPVEFPATKS RRRRASSSAS TPWSSPASIE 180 LMEDVTPKSS STPSVDLSQD GPQEGMDATQ VDAESRDGDS TEYQDDKEFG IGDLVWGKIK 240 GFSWWPAMVV SWKATSKRQA MPGMRWVQWF GDGKFSEIAA DKLVALGLFS QHFNLATFNK 300 LVSYRKAMYH TLEKAMVRAG KTFPSRPGDS LEDQLKPMLE WAHGGFKPTG IEGLKPNNKQ 360 PEVHKSKVRR SGSRNLEARR RENKSRRRTT IDFAASEYST PPKRLKTNSY GGKDRGEDEE 420 SRERMASDVT NNKGNLEDRC LSCGKKNPVS FHPLFEGGLC QSCRDRFLEL FYMYDEDGYQ 480 SYCTVCCEGR ELLLCSNTSC CRCFCVECLE VLVGTGTAED AKLQEPWSCY MCLPQRCHGV 540 LRRRKDWNMR LQDFFTTDPD LEEFEPPKLY PAIPAAKRRP IRVLSLFDGI ATGYLVLKDL 600 GIKVEKYVAS EVCAESIAVG TIKHEGQIKY VNDVRKITKK NIEEWGPFDL VIGGSPCNDL 660 SNVNPARKGL YEGTGRLFFE FYHLLNYTRP KEGDNRPFFW MFENVVAMKV NDKKDISRFL 720 ACNPVMIDAI KVSAAHRARY FWGNLPGMNR PVIASKNDKL ELQDCLEFSR TAKLKKVQTI 780 TTKSNSIRQG KNQLFPVVMN GKDDVLWCTE LERIFGFPAH YTDVSNMGRG ARQKLLGRSW 840 SVPVIRHLFA PLKDYFACE 859 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DNMT3B | A0A452DST5 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | DNMT3B | 1789 | Q9UBC3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Dnmt3b | 13436 | O88509 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | DNMT3B | 458174 | A0A2I3SYU8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DNMT3B | A0A287ABQ3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dnmt3b | 444985 | Q1LZ51 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dnmt3bb.1 | 317744 | Q588C6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0000775 | chromosome, centromeric region |
| GO:0000792 | heterochromatin |
| GO:0005720 | nuclear heterochromatin |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0003682 | chromatin binding |
| GO:0003886 | DNA (cytosine-5-)-methyltransferase activity |
| GO:0051718 | DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates |
| GO:0003677 | DNA binding |
| GO:0042826 | histone deacetylase binding |
| GO:0008168 | methyltransferase activity |
| GO:0003714 | transcription corepressor activity |
| GO:0090116 | C-5 methylation of cytosine |
| GO:0071230 | cellular response to amino acid stimulus |
| GO:0071549 | cellular response to dexamethasone stimulus |
| GO:0071455 | cellular response to hyperoxia |
| GO:0006306 | DNA methylation |
| GO:0043045 | DNA methylation involved in embryo development |
| GO:0060821 | inactivation of X chromosome by DNA methylation |
| GO:0006346 | methylation-dependent chromatin silencing |
| GO:0045814 | negative regulation of gene expression, epigenetic |
| GO:0051573 | negative regulation of histone H3-K9 methylation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0010628 | positive regulation of gene expression |
| GO:0051571 | positive regulation of histone H3-K4 methylation |
| GO:0045666 | positive regulation of neuron differentiation |
| GO:0031503 | protein-containing complex localization |
| GO:0006349 | regulation of gene expression by genetic imprinting |
| GO:0014823 | response to activity |
| GO:0031000 | response to caffeine |
| GO:0042220 | response to cocaine |
| GO:0042493 | response to drug |
| GO:0032355 | response to estradiol |
| GO:0001666 | response to hypoxia |
| GO:0010212 | response to ionizing radiation |
| GO:0009636 | response to toxic substance |
| GO:0033189 | response to vitamin A |