| Tag | Content |
|---|---|
| Uniprot ID | O88509; O88510; O88511; |
| Entrez ID | 13436 |
| Genbank protein ID | AAF74521.1; AAF74522.1; AAF74516.1; AAF74518.1; AAF74515.1; AAC40179.2; AAC40178.2; AAF74519.1; AAC40180.2; AAF74520.1; AAF74517.1; |
| Genbank nucleotide ID | NM_001003960.4; NM_001003961.4; NM_001271745.1; NM_001271744.1; NM_001271747.1; NM_010068.5; |
| Ensembl protein ID | ENSMUSP00000099439; ENSMUSP00000099440; ENSMUSP00000080334; ENSMUSP00000105395; ENSMUSP00000072761; ENSMUSP00000086370; ENSMUSP00000105394; ENSMUSP00000105396; |
| Ensembl nucleotide ID | ENSMUSG00000027478 |
| Gene name | DNA (cytosine-5)-methyltransferase 3B |
| Gene symbol | Dnmt3b |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5 |
| Data sources | Manually collected |
| Reference | 20587527 |
| Functional description | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Functions as a transcriptional corepressor by associating with ZHX1 (By similarity). Required for DUX4 silencing in somatic cells (By similarity). |
| Sequence | MKGDSRHLNE EEGASGYEEC IIVNGNFSDQ SSDTKDAPSP PVLEAICTEP VCTPETRGRR 60 SSSRLSKREV SSLLNYTQDM TGDGDRDDEV DDGNGSDILM PKLTRETKDT RTRSESPAVR 120 TRHSNGTSSL ERQRASPRIT RGRQGRHHVQ EYPVEFPATR SRRRRASSSA STPWSSPASV 180 DFMEEVTPKS VSTPSVDLSQ DGDQEGMDTT QVDAESRDGD STEYQDDKEF GIGDLVWGKI 240 KGFSWWPAMV VSWKATSKRQ AMPGMRWVQW FGDGKFSEIS ADKLVALGLF SQHFNLATFN 300 KLVSYRKAMY HTLEKARVRA GKTFSSSPGE SLEDQLKPML EWAHGGFKPT GIEGLKPNKK 360 QPVVNKSKVR RSDSRNLEPR RRENKSRRRT TNDSAASESP PPKRLKTNSY GGKDRGEDEE 420 SRERMASEVT NNKGNLEDRC LSCGKKNPVS FHPLFEGGLC QSCRDRFLEL FYMYDEDGYQ 480 SYCTVCCEGR ELLLCSNTSC CRCFCVECLE VLVGAGTAED AKLQEPWSCY MCLPQRCHGV 540 LRRRKDWNMR LQDFFTTDPD LEEFEPPKLY PAIPAAKRRP IRVLSLFDGI ATGYLVLKEL 600 GIKVEKYIAS EVCAESIAVG TVKHEGQIKY VNDVRKITKK NIEEWGPFDL VIGGSPCNDL 660 SNVNPARKGL YEGTGRLFFE FYHLLNYTRP KEGDNRPFFW MFENVVAMKV NDKKDISRFL 720 ACNPVMIDAI KVSAAHRARY FWGNLPGMNR PVMASKNDKL ELQDCLEFSR TAKLKKVQTI 780 TTKSNSIRQG KNQLFPVVMN GKDDVLWCTE LERIFGFPAH YTDVSNMGRG ARQKLLGRSW 840 SVPVIRHLFA PLKDYFACE 859 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DNMT3B | A0A452DST5 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | DNMT3B | 1789 | Q9UBC3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Dnmt3b | 13436 | O88509 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | DNMT3B | 458174 | A0A2I3SYU8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DNMT3B | A0A287ABQ3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dnmt3b | 444985 | Q1LZ51 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dnmt3bb.1 | 317744 | Q588C6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003677 | DNA binding | ISO |
| GO:0003677 | DNA binding | IDA |
| GO:0003682 | chromatin binding | ISO |
| GO:0003714 | transcription corepressor activity | ISO |
| GO:0003886 | DNA (cytosine-5-)-methyltransferase activity | ISO |
| GO:0003886 | DNA (cytosine-5-)-methyltransferase activity | IDA |
| GO:0003886 | DNA (cytosine-5-)-methyltransferase activity | IGI |
| GO:0005515 | protein binding | IPI |
| GO:0008168 | methyltransferase activity | IDA |
| GO:0042826 | histone deacetylase binding | ISO |
| GO:0046872 | metal ion binding | IEA |
| GO:0051718 | DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates | IDA |
| GO:0051719 | DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates | TAS |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISO |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP |
| GO:0006306 | DNA methylation | IGI |
| GO:0006306 | DNA methylation | IMP |
| GO:0006346 | methylation-dependent chromatin silencing | IGI |
| GO:0006349 | regulation of gene expression by genetic imprinting | IMP |
| GO:0010628 | positive regulation of gene expression | ISO |
| GO:0031503 | protein-containing complex localization | IDA |
| GO:0043045 | DNA methylation involved in embryo development | IGI |
| GO:0043045 | DNA methylation involved in embryo development | IEP |
| GO:0045666 | positive regulation of neuron differentiation | ISO |
| GO:0045814 | negative regulation of gene expression, epigenetic | IMP |
| GO:0045892 | negative regulation of transcription, DNA-templated | ISO |
| GO:0051571 | positive regulation of histone H3-K4 methylation | ISO |
| GO:0051573 | negative regulation of histone H3-K9 methylation | ISO |
| GO:0060821 | inactivation of X chromosome by DNA methylation | IMP |
| GO:0071230 | cellular response to amino acid stimulus | IDA |
| GO:0090116 | C-5 methylation of cytosine | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000775 | chromosome, centromeric region | IDA |
| GO:0000792 | heterochromatin | IDA |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005720 | nuclear heterochromatin | IDA |
| GO:0005737 | cytoplasm | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-212165 | Epigenetic regulation of gene expression | IEA |
| R-MMU-212300 | PRC2 methylates histones and DNA | IEA |
| R-MMU-2990846 | SUMOylation | IEA |
| R-MMU-3108232 | SUMO E3 ligases SUMOylate target proteins | IEA |
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-4655427 | SUMOylation of DNA methylation proteins | IEA |
| R-MMU-597592 | Post-translational protein modification | IEA |
| R-MMU-74160 | Gene expression (Transcription) | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0010 | Activator |
| KW-0025 | Alternative splicing |
| KW-0164 | Citrullination |
| KW-0238 | DNA-binding |
| KW-1017 | Isopeptide bond |
| KW-0479 | Metal-binding |
| KW-0489 | Methyltransferase |
| KW-0539 | Nucleus |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0678 | Repressor |
| KW-0949 | S-adenosyl-L-methionine |
| KW-0808 | Transferase |
| KW-0832 | Ubl conjugation |
| KW-0862 | Zinc |
| KW-0863 | Zinc-finger |