| Tag | Content |
|---|---|
| Uniprot ID | A0A287AZD5 |
| Entrez ID | |
| Genbank protein ID | HDA51278.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSSSCP00000049256 |
| Ensembl nucleotide ID | ENSSSCG00000007436 |
| Gene name | Matrix metalloproteinase-9 |
| Gene symbol | MMP9 |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSPWQPLVLV LLVLGCSAAP KPRQPTFVVF PGDLRTNLSD RQLAEEYLYR YGYTQVAEMT 60 DRKQSLEPAL KLLQQRLSLP QTGELDTTTL NAMRAPRCGV PDLGKFQTFE GDLKWHHHDI 120 TYWIQNYSED LPRDVIDDAF ARAFALWSEV TPLNFTRVYG PNADIVIQFG VKEHGDGYPF 180 DGKDGLLAHA FPPGPGIQGD AHFDDEELWS LGKGVVVPTY FGNAKGAACH FPFTFEGRSY 240 SACTTDGRSD DMLWCSTTAD YDTDRQFGFC PSERLFTRDG NADGKPCVFP FTFEGRSYSS 300 CTTDGRSDGY RWCGTTANYD QDKLYGFCPT RADSTVTGGN SAGDLCVFPF TFLGKEYSAC 360 TREGRSDGHL WCATTSNFDK DKKWGFCPDQ GYSLFLVAAH EFGHALGLDH STVPEALMYP 420 MYSFTEEHPL HEDDVRGIQY LYGSRPKPEP RPPTTTTAEP QSTVPPTVCV TGPPTTRPSE 480 RSTAGPTGPP SAGPTGPPTA GPSAAPTVSL GPGEDICNVD IFDAIAEIRN RLHFFKDGKY 540 WRLSEGKEHR VQGPFLIKDR WPALPHKLDS AFEEPLSKKI FFFSGRQVWV YTGASVLGPR 600 RLDKLGLGPE VARVTGALPR EAGKVLLFSQ QNFWRFDVKT QKVDSRSATR VDQMFPGVPL 660 NTHDIFQYQE KAYFCQARFF WRVSSRNEVN QVDYVGYVTF DLLKCPED 708 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MMP9 | F1P6A2 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | MMP9 | A0A452EYC3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MMP9 | 4318 | P14780 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Mmp9 | 17395 | P41245 | E12.5, E13.5, E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | MMP9 | 458294 | H2QKI0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MMP9 | A0A287AZD5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mmp9 | D3ZYK8 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | mmp9 | F1QC76 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0042802 | identical protein binding |
| GO:0004222 | metalloendopeptidase activity |
| GO:0008270 | zinc ion binding |
| GO:0071276 | cellular response to cadmium ion |
| GO:0034614 | cellular response to reactive oxygen species |
| GO:0030574 | collagen catabolic process |
| GO:0007566 | embryo implantation |
| GO:0035987 | endodermal cell differentiation |
| GO:0030198 | extracellular matrix organization |
| GO:2001258 | negative regulation of cation channel activity |
| GO:2001268 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| GO:2000697 | negative regulation of epithelial cell differentiation involved in kidney development |
| GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway |
| GO:0043388 | positive regulation of DNA binding |
| GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway |
| GO:0051549 | positive regulation of keratinocyte migration |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:1900122 | positive regulation of receptor binding |
| GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| GO:1904707 | positive regulation of vascular smooth muscle cell proliferation |
| GO:1904645 | response to amyloid-beta |
| GO:0001501 | skeletal system development |
| InterPro ID | InterPro Term |
|---|---|
| IPR000562 | FN_type2_dom |
| IPR036943 | FN_type2_sf |
| IPR000585 | Hemopexin-like_dom |
| IPR036375 | Hemopexin-like_dom_sf |
| IPR018487 | Hemopexin-like_repeat |
| IPR018486 | Hemopexin_CS |
| IPR013806 | Kringle-like |
| IPR033739 | M10A_MMP |
| IPR024079 | MetalloPept_cat_dom_sf |
| IPR001818 | Pept_M10_metallopeptidase |
| IPR021190 | Pept_M10A |
| IPR021158 | Pept_M10A_Zn_BS |
| IPR006026 | Peptidase_Metallo |
| IPR002477 | Peptidoglycan-bd-like |
| IPR036365 | PGBD-like_sf |
| IPR036366 | PGBDSf |