| Tag | Content |
|---|---|
| Uniprot ID | D3ZYK8 |
| Entrez ID | |
| Genbank protein ID | EDL96479.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000023965 |
| Ensembl nucleotide ID | ENSRNOG00000017539 |
| Gene name | Matrix metallopeptidase 9 |
| Gene symbol | Mmp9 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MNPWQPLLLV LLALGYSFAA PHQRQPTYVV FPRDLKTSNL TDTQLAEDYL YRYGYTRAAQ 60 MMGEKQSLRP ALLMLQKQLS LPQTGELDSE TLKAIRSPRC GVPDVGKFQT FEGDLKWHHH 120 NITYWIQSYT EDLPRDVIDD SFARAFAVWS AVTPLTFTRV YGLEADIVIQ FGVAEHGDGY 180 PFDGKDGLLA HAFPPGPGIQ GDAHFDDDEL WSLGKGAVVP TYFGNANGAP CHFPFTFEGR 240 SYLSCTTDGR NDGKPWCGTT ADYDTDRKYG FCPSENLYTE HGNGDGKPCV FPFIFEGHSY 300 SACTTKGRSD GYRWCATTAN YDQDKLYGFC PTRADVTVTG GNSAGEMCVF PFVFLGKQYS 360 TCTGEGRSDG RLWCATTSNF DADKKWGFCP DQGYSLFLVA AHEFGHALGL DHSSVPEALM 420 YPMYHYHEDS PLHEDDIKGI QHLYGRGSKP DPRPPATTAA EPQPTAPPTM CPTAPPMAYP 480 TGGPTVAPTG APSPGPTGPP TAGPSEAPTE SSTPVDNPCN VDVFDAIADI QGALHFFKDG 540 RYWKFSNHGG SQLQGPFLIA RTWPALPAKL NSAFEDPQSK KIFFFSGRKM WVYTGQSVLG 600 PRSLDKLGLG SEVTLVTGLL PRRGGKALLI SRERIWKFDL KSQKVDPQSV TRLDNEFSGV 660 PWNSHNVFHY QDKAYFCHDK YFWRVSFHNR VNQVDHVAYV TYDLLQCP 708 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MMP9 | F1P6A2 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | MMP9 | A0A452EYC3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MMP9 | 4318 | P14780 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Mmp9 | 17395 | P41245 | E12.5, E13.5, E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | MMP9 | 458294 | H2QKI0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MMP9 | A0A287AZD5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mmp9 | D3ZYK8 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | mmp9 | F1QC76 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0042802 | identical protein binding |
| GO:0004222 | metalloendopeptidase activity |
| GO:0008270 | zinc ion binding |
| GO:0071276 | cellular response to cadmium ion |
| GO:0034614 | cellular response to reactive oxygen species |
| GO:0030574 | collagen catabolic process |
| GO:0007566 | embryo implantation |
| GO:0035987 | endodermal cell differentiation |
| GO:0030198 | extracellular matrix organization |
| GO:2001258 | negative regulation of cation channel activity |
| GO:2001268 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| GO:2000697 | negative regulation of epithelial cell differentiation involved in kidney development |
| GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway |
| GO:0043388 | positive regulation of DNA binding |
| GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway |
| GO:0051549 | positive regulation of keratinocyte migration |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:1900122 | positive regulation of receptor binding |
| GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| GO:1904707 | positive regulation of vascular smooth muscle cell proliferation |
| GO:1904645 | response to amyloid-beta |
| GO:0001501 | skeletal system development |
| InterPro ID | InterPro Term |
|---|---|
| IPR000562 | FN_type2_dom |
| IPR036943 | FN_type2_sf |
| IPR000585 | Hemopexin-like_dom |
| IPR036375 | Hemopexin-like_dom_sf |
| IPR018487 | Hemopexin-like_repeat |
| IPR018486 | Hemopexin_CS |
| IPR013806 | Kringle-like |
| IPR033739 | M10A_MMP |
| IPR024079 | MetalloPept_cat_dom_sf |
| IPR001818 | Pept_M10_metallopeptidase |
| IPR021190 | Pept_M10A |
| IPR021158 | Pept_M10A_Zn_BS |
| IPR006026 | Peptidase_Metallo |
| IPR002477 | Peptidoglycan-bd-like |
| IPR036365 | PGBD-like_sf |
| IPR036366 | PGBDSf |
| IPR006970 | PT |