| Tag | Content |
|---|---|
| Uniprot ID | H2QKI0; A0A2J8MJT4; |
| Entrez ID | 458294 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_003316973.3 |
| Ensembl protein ID | ENSPTRP00000023334 |
| Ensembl nucleotide ID | ENSPTRG00000013577 |
| Gene name | Matrix metallopeptidase 9 |
| Gene symbol | MMP9 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSLWQPLVLV LLVLGCCFAA PRQRQSTLVL FPGDLRTNLT DRQLAEEYLY RYGYTRVAEM 60 RGESKSLGPA LLLLQKQLSL PETGELDSAT LKAMRTPRCG VPDLGKFQTF EGDLKWHHHN 120 ITYWIQNYSE DLPRAVIDDA FARAFALWSA VTPLTFTRVY SRDADIVIQF GVAEHGDGYP 180 FDGKDGLLAH AFPPGPGIQG DAHFDDDELW SLGKGVVVPT RFGNADGAAC HFPFIFEGRS 240 YSACTTDGRS DGLPWCSTTA NYDTDDRFGF CPSERLYTQD GNADGKPCQF PFIFQGQSYS 300 ACTTDGRSDG YRWCATTANY DRDKLFGFCP TRADSTVMGG NSAGELCVFP FTFLGKEYST 360 CTSEGRGDGR LWCATTSNFD SDKKWGFCPD QGYSLFLVAA HEFGHALGLD HSSVPEALMY 420 PMYRFTEGPP LHKDDVNGIR HLYGPRPEPE PRPPTTTTPQ PTAPPTVCPT GPPTVRPSER 480 PTAGPTGPPT AGPSTATTVP LSPVDDACNV NIFDAIAEIG NQLYLFKDGK YWRFSEGRGS 540 RPQGPFLIAD KWPALPRKLD SVFEEPLSKK LFFFSGRQVW VYTGASVLGP RRLDKLGLGA 600 DVAQVTGALR SGRGKMLLFS GRRLWRFDVK AQMVDPRSAS EVDRMFPGVP LDTHDVFQYR 660 EKAYFCQDRF YWRVSSRNEL NQVDQVGYVT YDILQCPED 699 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MMP9 | F1P6A2 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | MMP9 | A0A452EYC3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MMP9 | 4318 | P14780 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Mmp9 | 17395 | P41245 | E12.5, E13.5, E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | MMP9 | 458294 | H2QKI0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MMP9 | A0A287AZD5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mmp9 | D3ZYK8 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | mmp9 | F1QC76 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0042802 | identical protein binding |
| GO:0004222 | metalloendopeptidase activity |
| GO:0008270 | zinc ion binding |
| GO:0071276 | cellular response to cadmium ion |
| GO:0034614 | cellular response to reactive oxygen species |
| GO:0030574 | collagen catabolic process |
| GO:0007566 | embryo implantation |
| GO:0035987 | endodermal cell differentiation |
| GO:0030198 | extracellular matrix organization |
| GO:2001258 | negative regulation of cation channel activity |
| GO:2001268 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| GO:2000697 | negative regulation of epithelial cell differentiation involved in kidney development |
| GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway |
| GO:0043388 | positive regulation of DNA binding |
| GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway |
| GO:0051549 | positive regulation of keratinocyte migration |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:1900122 | positive regulation of receptor binding |
| GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| GO:1904707 | positive regulation of vascular smooth muscle cell proliferation |
| GO:1904645 | response to amyloid-beta |
| GO:0001501 | skeletal system development |
| InterPro ID | InterPro Term |
|---|---|
| IPR000562 | FN_type2_dom |
| IPR036943 | FN_type2_sf |
| IPR000585 | Hemopexin-like_dom |
| IPR036375 | Hemopexin-like_dom_sf |
| IPR018487 | Hemopexin-like_repeat |
| IPR018486 | Hemopexin_CS |
| IPR013806 | Kringle-like |
| IPR033739 | M10A_MMP |
| IPR024079 | MetalloPept_cat_dom_sf |
| IPR001818 | Pept_M10_metallopeptidase |
| IPR021190 | Pept_M10A |
| IPR021158 | Pept_M10A_Zn_BS |
| IPR006026 | Peptidase_Metallo |
| IPR002477 | Peptidoglycan-bd-like |
| IPR036365 | PGBD-like_sf |
| IPR036366 | PGBDSf |