| Tag | Content |
|---|---|
| Uniprot ID | A0A452EYC3 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000016938 |
| Ensembl nucleotide ID | ENSCHIG00000016983 |
| Gene name | Uncharacterized protein |
| Gene symbol | MMP9 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSPRQPLVLA LLVLACCSAA PSPRQPTVVV FPGERRTSLT NRQLAEEYLY RYGYTPAAEL 60 SEDGQSLRRA LLSFQRRLSL PETGELDSTT LDAMRAPRCG VPDLGGFQTF EGELKWHHHN 120 ITYWIQNYSE DLPRDVIDDA FARAFALWSA VTPLTFTRVY GREADIVIQF GVREHGDGYP 180 FDGKNGLLAH AFPPGSGIQG DAHFDDEELW SLGKGVVIPT YFGNAKGAAC HFPFTFEGRS 240 YSSCTTDGRS DDVLWCSTTA DYDADRQFGF CPSERLYTQD GNADGKPCVF PFTFEGRTYS 300 ACTSDGRSDG YRWCATTANY DQDKLYGFCP TRVDATVTGG NAAGELCVFP FTFLGKEYSA 360 CTTEGRNDGH LWCATTSNFD KDKKWGFCPD QGYSLFLVAA HEFGHALGLD HSSVPEALMY 420 PMYRFTEEHP LHRDDVQGIQ HLYGPRPEPE PRPPATTTAE PQPTAPPTVC VTGPPTARPS 480 EGPTTGPTGP PAAGPTGPPT AGPSAAPTES PDPAEDVCNV DIFDAIAEIG NRLHFFKAGK 540 YWKLSEGGGR RVQGPFLVKS TWPALPRKLD SAFEDPLTKK IFFFSGRQVW VYTGASVLGP 600 RRLDKLGLGP EVAQVTGALP RPGGKVLLFS GQSFWRFDVK TQKVDPQSVT PVDQMFPGVP 660 ISTHDIFQYQ EKAYFCQDHF FWRVSSRNEV NQVDYVGYVT FDLLKCPED 709 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MMP9 | F1P6A2 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | MMP9 | A0A452EYC3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MMP9 | 4318 | P14780 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Mmp9 | 17395 | P41245 | E12.5, E13.5, E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | MMP9 | 458294 | H2QKI0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MMP9 | A0A287AZD5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Mmp9 | D3ZYK8 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | mmp9 | F1QC76 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0042802 | identical protein binding |
| GO:0004222 | metalloendopeptidase activity |
| GO:0008270 | zinc ion binding |
| GO:0071276 | cellular response to cadmium ion |
| GO:0034614 | cellular response to reactive oxygen species |
| GO:0030574 | collagen catabolic process |
| GO:0007566 | embryo implantation |
| GO:0035987 | endodermal cell differentiation |
| GO:0030198 | extracellular matrix organization |
| GO:2001258 | negative regulation of cation channel activity |
| GO:2001268 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| GO:2000697 | negative regulation of epithelial cell differentiation involved in kidney development |
| GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway |
| GO:0043388 | positive regulation of DNA binding |
| GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway |
| GO:0051549 | positive regulation of keratinocyte migration |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:1900122 | positive regulation of receptor binding |
| GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| GO:1904707 | positive regulation of vascular smooth muscle cell proliferation |
| GO:1904645 | response to amyloid-beta |
| GO:0001501 | skeletal system development |
| InterPro ID | InterPro Term |
|---|---|
| IPR000562 | FN_type2_dom |
| IPR036943 | FN_type2_sf |
| IPR000585 | Hemopexin-like_dom |
| IPR036375 | Hemopexin-like_dom_sf |
| IPR018487 | Hemopexin-like_repeat |
| IPR013806 | Kringle-like |
| IPR033739 | M10A_MMP |
| IPR024079 | MetalloPept_cat_dom_sf |
| IPR001818 | Pept_M10_metallopeptidase |
| IPR021190 | Pept_M10A |
| IPR021158 | Pept_M10A_Zn_BS |
| IPR006026 | Peptidase_Metallo |
| IPR002477 | Peptidoglycan-bd-like |
| IPR036365 | PGBD-like_sf |
| IPR036366 | PGBDSf |
| IPR006970 | PT |