| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3S3S0; A0A2J8PBX9; |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSPTRP00000071642 |
| Ensembl nucleotide ID | ENSPTRG00000003003 |
| Gene name | Fibroblast growth factor receptor |
| Gene symbol | FGFR2 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MVSWGRFICL VVVTMATLSL ARPSFSLVED TTLEPEGAPY WTNTEKMEKR LHAVPAANTV 60 KFRCPAGGNP TPTMRWLKNG KEFKQEHRIG GYKVRNQHWS LIMESVVPSD KGNYTCVVEN 120 EYGSINHTYH LDVVERSPHR PILQAGLPAN ASTVVGGDVE FVCKVYSDAQ PHIQWIKHVE 180 KNGSKYGPDG LPYLKVLKHS GINSSNAEVL ALFNVTEADA GEYICKVSNY IGQANQSAWL 240 TVLPKQQAPG REKEITASPD YLEIAIYCIG VFLIACMVVT VILCRMKNTT KKPDFSSQPA 300 VHKLTKRIPL RRQVTVSAES SSSMNSNTPL VRITTRLSST ADTPMLAGVS EYELPEDPKW 360 EFPRDKLTLG KPLGEGCFGQ VVMAEAVGID KDKPKEAVTV AVKMLKDDAT EKDLSDLVSE 420 MEMMKMIGKH KNIINLLGAC TQDGPLYVIV EYASKGNLRE YLRARRPPGM EYSYDINRVP 480 EEQMTFKDLV SCTYQLARGM EYLASQKCIH RDLAARNVLV TENNVMKIAD FGLARDINNI 540 DYYKKTTNGR LPVKWMAPEA LFDRVYTHQS DVWSFGVLMW EIFTLGGSPY PGIPVEELFK 600 LLKEGHRMDK PANCTNELYM MMRDCWHAVP SQRPTFKQLV EDLDRILTLT TNEEYLDLSQ 660 PLEQYSPSYP DTRSSCSSGD DSVFSPDPMP YEPCLPQYPH INGSVKT 707 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FGFR2 | 102170938 | A0A452F370 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | FGFR2 | 2263 | P21802 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Fgfr2 | 14183 | P21803 | CPO | E13.5, E14.0, E14.5, E16.0, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FGFR2 | A0A2I3S3S0 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480U9V2 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | FGFR2 | 100009417 | G1SSB0 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Fgfr2 | 25022 | F1LSG7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | fgfr2 | A4JYI8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005524 | ATP binding |
| GO:0005007 | fibroblast growth factor-activated receptor activity |
| GO:0008284 | positive regulation of cell population proliferation |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1015 | Disulfide bond |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| InterPro ID | InterPro Term |
|---|---|
| IPR016248 | FGF_rcpt_fam |
| IPR041159 | FGFR_TM |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |