| Tag | Content |
|---|---|
| Uniprot ID | A4JYI8 |
| Entrez ID | |
| Genbank protein ID | CAM73170.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000089041 |
| Ensembl nucleotide ID | ENSDARG00000058115 |
| Gene name | Fibroblast growth factor receptor |
| Gene symbol | fgfr2 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGSVSRGRPR RRGGCGDTPT TDGMFARGWL LGALLLMTLA TVSVARPSLK IDLVNTSAPE 60 DAISSGDDED DTERSDDVGA DGEQMRLPYW TFPEKMEKKL HAVPAANTVK FRCAAAGNPK 120 PKMRWLKNAK PFRQEDRMGG YKVRLQHWTL IMESVVPSDK GNYTCLVENQ YGSINHTYTL 180 DVVERSPHRP ILQAGLPANV TVQVGQDAKF VCKVYSDAQP HIQWLQHYTK NGSRYGPDGL 240 PYVRVLKTAG VNTTDKEIEV LYLPNVTFED AGEYTCLAGN SIGISYHTAW LTVHPAETNP 300 IETDYPPDYV EIAIYCIGVF LIACMVVIVV VCRMRTSAKK PDFSSQPAVH KLTKQIPLRR 360 QVTVSSDSSS SMSSSTPLVR ITTRRSSAHD DPIPEYDLPE DPRWEFSRDK LTLGKPLGEG 420 CFGQVVMAEA LGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM IGRHKNIINL 480 LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI ARVSDEPLTF KDLVSCTYQV 540 ARGMEYLASQ KCIHRDLAAR NVLVTESNVM KIADFGLARD VHNIDYYKKT TNGRLPVKWM 600 APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH RMDKPANCTN 660 ELYMMMKDCW HAISSHRPTF KQLVEDLDRI LTLATNEEYL DLCAPVEQYS PSFPDTRSSC 720 SSGDDSVFSH DPLADEPCLP KYQHINGGIK T 751 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FGFR2 | 102170938 | A0A452F370 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | FGFR2 | 2263 | P21802 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Fgfr2 | 14183 | P21803 | CPO | E13.5, E14.0, E14.5, E16.0, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FGFR2 | A0A2I3S3S0 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480U9V2 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | FGFR2 | 100009417 | G1SSB0 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Fgfr2 | 25022 | F1LSG7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | fgfr2 | A4JYI8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0005524 | ATP binding |
| GO:0005007 | fibroblast growth factor-activated receptor activity |
| GO:0008284 | positive regulation of cell population proliferation |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-1015 | Disulfide bond |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| InterPro ID | InterPro Term |
|---|---|
| IPR016248 | FGF_rcpt_fam |
| IPR041159 | FGFR_TM |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |