| Tag | Content |
|---|---|
| Uniprot ID | F1LSG7 |
| Entrez ID | 25022 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_012712.1 |
| Ensembl protein ID | ENSRNOP00000059005 |
| Ensembl nucleotide ID | ENSRNOG00000016374 |
| Gene name | Fibroblast growth factor receptor |
| Gene symbol | Fgfr2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGLPSTWRYG TGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT TLEPEEPPTK 60 YQISQPEACV VAPGESLELR CMLKDAAVIS WTKDGVHLGP NNRTVLIGEY LQIKGATPRD 120 SGLYACAAAR TVDSETLYFM VNVTDAISSG DDEDDTDSSE DFVSENRSNQ RAPYWTNTEK 180 MEKRLHAVPA ANTVKFRCPA GGNPTPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV 240 VPSDKGNYTC LVENEYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY 300 SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKHSGINSSN AEVLALFNVT EMDAGEYICK 360 VSNYIGQANQ SAWLTVLPKQ QAPVREKEIT ASPDYLEIAI YCIGVFLIAC MVVTVIFCRM 420 KTTTKKPDFS SQPAVHKLTK RIPLRRQVTV SAESSSSMNS NTPLVRITTR LSSTADTPML 480 AGVSEYELPE DPKWEFPRDK LTLGKPLGEG CFGQVVMAEA VGIDKDRPKE AVTVAVKMLK 540 DDATEKDLSD LVSEMEMMKM IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR 600 PPGMEYSYDI NRVPEEQMTF KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM 660 KIADFGLARD INNIDYYKKT TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG 720 GSPYPGIPVE ELFKLLKEGH RMDKPTNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDLDRI 780 LTLTTNEEYL DLTQPLEQYS PSYPDTRSSC SSGDDSVFSP DPMPYDPCLP QYPHINGSVK 840 T 841 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FGFR2 | 102170938 | A0A452F370 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | FGFR2 | 2263 | P21802 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Fgfr2 | 14183 | P21803 | CPO | E13.5, E14.0, E14.5, E16.0, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FGFR2 | A0A2I3S3S0 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480U9V2 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | FGFR2 | 100009417 | G1SSB0 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Fgfr2 | 25022 | F1LSG7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | fgfr2 | A4JYI8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0005938 | cell cortex |
| GO:0009986 | cell surface |
| GO:0062023 | collagen-containing extracellular matrix |
| GO:0005737 | cytoplasm |
| GO:0060076 | excitatory synapse |
| GO:0005887 | integral component of plasma membrane |
| GO:0005634 | nucleus |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0017134 | fibroblast growth factor binding |
| GO:0005007 | fibroblast growth factor-activated receptor activity |
| GO:0042802 | identical protein binding |
| GO:0042803 | protein homodimerization activity |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| GO:0001525 | angiogenesis |
| GO:0009887 | animal organ morphogenesis |
| GO:0007409 | axonogenesis |
| GO:0060348 | bone development |
| GO:0030282 | bone mineralization |
| GO:0060349 | bone morphogenesis |
| GO:0060667 | branch elongation involved in salivary gland morphogenesis |
| GO:0060670 | branching involved in labyrinthine layer morphogenesis |
| GO:0060442 | branching involved in prostate gland morphogenesis |
| GO:0060445 | branching involved in salivary gland morphogenesis |
| GO:0048755 | branching morphogenesis of a nerve |
| GO:0060449 | bud elongation involved in lung branching |
| GO:0045165 | cell fate commitment |
| GO:0007267 | cell-cell signaling |
| GO:0044344 | cellular response to fibroblast growth factor stimulus |
| GO:0071300 | cellular response to retinoic acid |
| GO:0071560 | cellular response to transforming growth factor beta stimulus |
| GO:0060365 | coronal suture morphogenesis |
| GO:0048565 | digestive tract development |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0048557 | embryonic digestive tract morphogenesis |
| GO:0048568 | embryonic organ development |
| GO:0048562 | embryonic organ morphogenesis |
| GO:0009880 | embryonic pattern specification |
| GO:0003416 | endochondral bone growth |
| GO:0061031 | endodermal digestive tract morphogenesis |
| GO:0048730 | epidermis morphogenesis |
| GO:0030855 | epithelial cell differentiation |
| GO:0060664 | epithelial cell proliferation involved in salivary gland morphogenesis |
| GO:0001837 | epithelial to mesenchymal transition |
| GO:0060441 | epithelial tube branching involved in lung morphogenesis |
| GO:0008543 | fibroblast growth factor receptor signaling pathway |
| GO:0035603 | fibroblast growth factor receptor signaling pathway involved in hemopoiesis |
| GO:0060595 | fibroblast growth factor receptor signaling pathway involved in mammary gland specification |
| GO:0035602 | fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell |
| GO:0035607 | fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development |
| GO:0035604 | fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow |
| GO:0022612 | gland morphogenesis |
| GO:0031069 | hair follicle morphogenesis |
| GO:0001701 | in utero embryonic development |
| GO:0042472 | inner ear morphogenesis |
| GO:0032808 | lacrimal gland development |
| GO:0060601 | lateral sprouting from an epithelium |
| GO:0070307 | lens fiber cell development |
| GO:0060174 | limb bud formation |
| GO:0048286 | lung alveolus development |
| GO:0030324 | lung development |
| GO:0060463 | lung lobe morphogenesis |
| GO:0060484 | lung-associated mesenchyme development |
| GO:0060615 | mammary gland bud formation |
| GO:0003149 | membranous septum morphogenesis |
| GO:0048762 | mesenchymal cell differentiation |
| GO:0060915 | mesenchymal cell differentiation involved in lung development |
| GO:0060916 | mesenchymal cell proliferation involved in lung development |
| GO:0048333 | mesodermal cell differentiation |
| GO:0030901 | midbrain development |
| GO:0016331 | morphogenesis of embryonic epithelium |
| GO:0007275 | multicellular organism development |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0050680 | negative regulation of epithelial cell proliferation |
| GO:0010839 | negative regulation of keratinocyte proliferation |
| GO:0045839 | negative regulation of mitotic nuclear division |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0007528 | neuromuscular junction development |
| GO:0042476 | odontogenesis |
| GO:0021769 | orbitofrontal cortex development |
| GO:0035265 | organ growth |
| GO:0030916 | otic vesicle formation |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0018108 | peptidyl-tyrosine phosphorylation |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| GO:0045787 | positive regulation of cell cycle |
| GO:0051781 | positive regulation of cell division |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0010628 | positive regulation of gene expression |
| GO:0033674 | positive regulation of kinase activity |
| GO:0043410 | positive regulation of MAPK cascade |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:0010518 | positive regulation of phospholipase activity |
| GO:0048661 | positive regulation of smooth muscle cell proliferation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0030177 | positive regulation of Wnt signaling pathway |
| GO:0009791 | post-embryonic development |
| GO:0060527 | prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis |
| GO:0060523 | prostate epithelial cord elongation |
| GO:0060512 | prostate gland morphogenesis |
| GO:0046777 | protein autophosphorylation |
| GO:0021860 | pyramidal neuron development |
| GO:0042127 | regulation of cell population proliferation |
| GO:0050678 | regulation of epithelial cell proliferation |
| GO:0070372 | regulation of ERK1 and ERK2 cascade |
| GO:0060688 | regulation of morphogenesis of a branching structure |
| GO:0051150 | regulation of smooth muscle cell differentiation |
| GO:0008589 | regulation of smoothened signaling pathway |
| GO:0048608 | reproductive structure development |
| GO:0045471 | response to ethanol |
| GO:0032496 | response to lipopolysaccharide |
| GO:0060529 | squamous basal epithelial stem cell differentiation involved in prostate gland acinus development |
| GO:0048489 | synaptic vesicle transport |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| GO:0001657 | ureteric bud development |
| GO:0055010 | ventricular cardiac muscle tissue morphogenesis |
| GO:0021847 | ventricular zone neuroblast division |
| GO:0042060 | wound healing |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1015 | Disulfide bond |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| InterPro ID | InterPro Term |
|---|---|
| IPR016248 | FGF_rcpt_fam |
| IPR041159 | FGFR_TM |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |