| Tag | Content |
|---|---|
| Uniprot ID | A0A452F370 |
| Entrez ID | 102170938 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018041428.1 |
| Ensembl protein ID | ENSCHIP00000018620 |
| Ensembl nucleotide ID | ENSCHIG00000017963 |
| Gene name | Fibroblast growth factor receptor |
| Gene symbol | FGFR2 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGLTSTWRYG RGQGIGTVTM VSWGRFLCLV VVTMATLSLA RPSFNLVDDT TVEPEEPPTK 60 YQISQPEVYV AAPRESLELR CLLRDAAMIS WTKDGVHLGP NNRTVLIGEY LQIKGATPRD 120 SGLYACTAAR NVDSETVYFM VNVTDAISSG DDEDDADGSE DFVSENSNSK RAPYWTNTEK 180 MEKRLHAVPA ANTVKFRCPA GGNPTPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV 240 VPSDKGNYTC VVENDYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY 300 SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKHSGINSSN AEVLALFNVT EADAGEYICK 360 VSNYIGQANQ SAWLTVLPKQ QAPVREKEIP ASPDYLEIAI YCIGVFFIAC MVVTVILCRM 420 RNTTKKPDFS SQPAVHKLTK RIPLRRQVTV SAESSSSMNS NTPLVRITTR LSSTADTPML 480 AGVSEYELPE DPKWEFPRDK LTLGKPLGEG CFGQVVMAEA VGIDKEKPKE AVTVAVKMLK 540 DDATEKDLSD LVSEMEMMKM IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR 600 PPGMEYSYDI NRVPEEQMAF KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM 660 KIADFGLARD INNIDYYKKT TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG 720 GSPYPGIPVE ELFKLLKEGH RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDLDRI 780 LTLTTNEEYL DLSQLLEQYS PSYPDTRSSC SSGDDSVFSP DPMPYEPCLP QYPHRNGSVK 840 T 841 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FGFR2 | 102170938 | A0A452F370 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | FGFR2 | 2263 | P21802 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Fgfr2 | 14183 | P21803 | CPO | E13.5, E14.0, E14.5, E16.0, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FGFR2 | A0A2I3S3S0 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480U9V2 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | FGFR2 | 100009417 | G1SSB0 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Fgfr2 | 25022 | F1LSG7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | fgfr2 | A4JYI8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005938 | cell cortex |
| GO:0009986 | cell surface |
| GO:0062023 | collagen-containing extracellular matrix |
| GO:0005887 | integral component of plasma membrane |
| GO:0005634 | nucleus |
| GO:0005524 | ATP binding |
| GO:0017134 | fibroblast growth factor binding |
| GO:0005007 | fibroblast growth factor-activated receptor activity |
| GO:0042803 | protein homodimerization activity |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0010839 | negative regulation of keratinocyte proliferation |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0043410 | positive regulation of MAPK cascade |
| GO:0010518 | positive regulation of phospholipase activity |
| GO:0046777 | protein autophosphorylation |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1015 | Disulfide bond |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| InterPro ID | InterPro Term |
|---|---|
| IPR016248 | FGF_rcpt_fam |
| IPR041159 | FGFR_TM |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |