| Tag | Content |
|---|---|
| Uniprot ID | G1SSB0 |
| Entrez ID | 100009417 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_008270454.2 |
| Ensembl protein ID | ENSOCUP00000006114 |
| Ensembl nucleotide ID | ENSOCUG00000007069 |
| Gene name | Fibroblast growth factor receptor |
| Gene symbol | FGFR2 |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGFTSTWRYG RGPGIGTVTM VGWGRFICLV MVTMATVSLA RPSFNLVEDA TVEPEEPPTK 60 YQISQPEVYV AAPGESLELR CLLKDASVIS WTKDGVHLGP NNRTVLIGEY LQIRGATPRD 120 SGLYACTAAR TVDSDTWYFM VNVTDAISSG DDEDDTDGAE DFVSENSNSK RAPYWTNTEK 180 MEKRLHAVPA ANTVKFRCPA GGSPTPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV 240 VPSDKGNYTC VVENEYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY 300 SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKHSGINSSN AEVLALFNVT EADAGEYICK 360 VSNYIGQANQ SAWLTVLPKQ QAPVREKEIT ASPDYLEIAI YCIGVFLIVC MVITVIVCRM 420 KTTSKKPDFS SQPAVHKLTK RIPLRRQVTV SAESSSSMNS NTPLVRITTR LSSAADTPML 480 AGVSEYELPE DPKWEFPRDK LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK 540 DDATEKDLSD LVSEMEMMKM IGKHKNIINL LGACTQDGPL YVLVEYASKG NLREYLRARR 600 PPGMEYSYDI NRVPEEQMTF KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM 660 KIADFGLARD INNIDYYKKT TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG 720 GSPYPGIPVE ELFKLLKEGH RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDLDRI 780 LTLTTNEEYL DLSQPLEQYS PSYPDSRSSC SSGDDSVFSP DPMPYEPRLP QYPHVNGSVQ 840 T 841 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FGFR2 | 102170938 | A0A452F370 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | FGFR2 | 2263 | P21802 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Fgfr2 | 14183 | P21803 | CPO | E13.5, E14.0, E14.5, E16.0, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FGFR2 | A0A2I3S3S0 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480U9V2 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | FGFR2 | 100009417 | G1SSB0 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Fgfr2 | 25022 | F1LSG7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | fgfr2 | A4JYI8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005524 | ATP binding |
| GO:0005007 | fibroblast growth factor-activated receptor activity |
| GO:0008284 | positive regulation of cell population proliferation |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1015 | Disulfide bond |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| InterPro ID | InterPro Term |
|---|---|
| IPR016248 | FGF_rcpt_fam |
| IPR041159 | FGFR_TM |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR011009 | Kinase-like_dom_sf |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |