| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3S6U5; A0A2J8QGP1; |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSPTRP00000072692 |
| Ensembl nucleotide ID | ENSPTRG00000011055 |
| Gene name | Multiple EGF like domains 8 |
| Gene symbol | MEGF8 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MALGKVLAMA LALALAVLGS LSPGARAGDC KGQRQVLREA PGFVTDGAGN YSVNGNCEWL 60 IEAPSPQHRI LLDFLFLDTE CTYDYLFVYD GDSPRGPLLA SLSGSTRPPP IEASSGKMLL 120 HLFSDANYNL LGFNASFRFS LCPGGCQSHG QCQPPGVCAC EPGWGGPDCG LQECSAYCGS 180 HGTCASPLGP CRCEPGFLGH ACDLHLWENQ GAGWWHNVSA RDPAFSARIG AAGAFLSPPG 240 LLAVFGGQDL NNALGDLVLY NFSANTWESW DLSPAPAARH SHVAVAWAGS LVLMGGELAD 300 GSLTNDVWAF SPLGRGHWEL LAPPASSSSG PPGLAGHAAA LVDDVWLYVS GGRTPHDLFS 360 SGLFRFRLDS TSGGYWEQVI PAGGRPPAAT GHSMVFHAPS RALLVHGGHR PSTARFSVRV 420 NSTELFHVDR HVWTTLKGRD GLQGPRERAF HTASVLGNYM VVYGGNVHTH YQEEKCYEDG 480 IFFYHLGCHQ WVSGAELAPP GTPEGRAAPP SGRYSHVAAV LGGSVLLVAG GYSGRPRGDL 540 MAYKVPPFVF QAPAPDYHLD YCSMYTDHSV CSRDPECSWC QGACQAAPPP GTPLGACPAA 600 SCLGLGRLLG DCQACLAFSS PTAPPRGPGT LGWCVHNESC LPRPEQARCR GEQISGTVGW 660 WGPAPVFVTS LEACVTQSFL PGLHLLTFQQ PPNTSQPDKE EVGRWVAHQE KETRRLQRPG 720 SARLFPLPGR DHKYAVEIQG QLNGSAGPGH SELTLLWDRT GVPGGSEISF FFLEPYRSSS 780 CTSYSSCLGC LADQGCGWCL TSATCHLRQG GAHCGDDGAG GSLLVLVPTL CPLCEEHRDC 840 HACTQDPFCE WHQSTSRKGD AACSRRGRGR GALKSPEECP PLCSQRLTCE DCLANSSQCA 900 WCQSTHTCFL FAAYLARYPH GGCRGWDDSV HSEPRCRSCD GFLTCHECLQ SHECGWCGNE 960 DNPTLGRCLQ GDFSGPLGGG NCSLWVGEGL GLPVALPARW AYARCPDVDE CRLGLARCHP 1020 RATCLNTPLS YECHCQRGYQ GDGISHCNRT CLEDCGHGVC SGPPDFTCVC DLGWTSDLPP 1080 PTPAPGPPAP RCSRDCGCSF HSHCRKRGPG FCDECQDWTW GEHCERCRPG SFGNATGSRG 1140 CRPCQCNGHG DPRRGHCDNL SGLCFCQDHT EGAHCQLCSP GYYGDPRAGG SCFRECGGRA 1200 LLTNVSSVAL GSRRVGGLLP PGGGAARAGP GLSYCVWVVS ATEELQPCAP GTLCPPLTLT 1260 FSPDSSTPCT LSYVLAFDGF PRFLDTGVVQ SDRSLIAAFC GQRRDRPLTV QALSGLLVLH 1320 WEANGSSSWG FNASVGSARC GSGGPGSCPV PQECVPQDGA AGAGLCRCPQ GWAGPHCRMA 1380 LCPENCNAHT GAGTCNQSLG VCICAEGFGG PDCATKLDGG QLVWETLMDS RLSADTASRF 1440 LHRLGHTMVD GPDATLWMFG GLGLPQGLLG NLYRYSVSER RWTQMLAGAE DGGPGPSPRS 1500 FHAAAYVPAG RGAMYLLGGL TAGGVTRDFW VLNLTTLQWR QEKAPQTVEL PAVAGHTLTA 1560 RQGLSLLLVG GYSPENGFNQ QLLEYQLATG TWVSGAQSGT PPTGLYGHSA VYHEATDSLY 1620 VFGGFRFHVE LAAPSPELYS LHCPDRTWSL LAPTQGAKRD RMRNVRGSSR GLGQVPGEQP 1680 GSWGFREVRK EMALWAALAG TGGFLEEISP HLKEPRPRLF HASALLGDTM VVLGGRSDPD 1740 EFSSDVLLYQ VNCNAWLLPD LTRPASVGPP MEESVAHAVA AVGSRLYISG GFGGVALGRL 1800 LALTLPPDPC RLLSSPEACN QSGACTWCHG ACLSGDQAHR LGCGGSPCSP MPRSPEECRR 1860 LRTCSECLAR HPRTLQPGDG EASTPRCKWC TNCPEGACIG RNGSCTSEND CRINQREVFW 1920 AGNCSEAACG AADCEQCTRE GKCMWTRQFK RTGETRRILS VQPTYDWTCF SHSLLNVSPM 1980 PVESSPPLPC PTPCHLLPNC TSCLDSKGAD GGWQHCVWSS SLQQCLSPSY LPLRCMAGGC 2040 GRLLRGPESC SLGCAQATQC ALCLRRPHCG WCAWGGQDGG GRCMEGGLSG PRDGLTCGRP 2100 GASWAFLSCP PEDECANGHH DCNETQNCHD QPHGYECSCK TGYTMDNMTG LCRPVCAQGC 2160 VNGSCVEPDH CRCHFGFVGR NCSTECRCNR HSECAGVGAR DHCLLCRNHT KGSHCEQCLP 2220 LFVGSAVGGG TCRPCHAFCR GNSHICISRK ELQMSKGEPK KYSLDPEEIE NWVTEGPSED 2280 EAVCVNCQNN SYGEKCESCL QGYFLLDGKC TKCQCNGHAD TCNEQDGTGC PCQNNTETGT 2340 CQGSSPSDRR DCYKYQCAKC RESFHGSPLG GQQCYRLISV EQECCLDPTS QTNCFHEPKR 2400 RALGPGRTVL FGVQPKFTNV DIRLTLDVTF GAVDLYVSTS YDTFVVRVAP DTGVHTVHIQ 2460 PPPAPPPPPP PADGGPRGAG DPGGAGASSG PGAPAEPRVR EVWPRGLITY VTVTEPSAVL 2520 VVRSVRDRLV ITYPHEHHAL KSSRFYLLLL GVGDPSGPGA NGSADSQGLL FFRQDQAHID 2580 LFVFFSVFFS CFFLFLSLCV LLWKAKQALD QRQEQRRHLQ EMTKMASRPF AKVTVCFPPD 2640 PTAPASAWKP AGLPPPAFRR SEPFLAPLLL TGAGGPWGPM GGGCCPPATT AGLRAGPITL 2700 EPTEDGMAGV ATLLLQLPGG PHAPNGACLG SALVTLRHRL HEYCGGGGGA GGSGHGTGAG 2760 RKGLLSQDNL TSMSL 2775 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MEGF8 | A0A452EQ38 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MEGF8 | 1954 | Q7Z7M0 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Megf8 | 269878 | P60882 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MEGF8 | A0A2I3S6U5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | MEGF8 | 100513862 | F1RGK2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Megf8 | 114029 | R9PXW3 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | megf8 | 791154 | F1QBZ9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005509 | calcium ion binding |
| InterPro ID | InterPro Term |
|---|---|
| IPR000859 | CUB_dom |
| IPR001881 | EGF-like_Ca-bd_dom |
| IPR013032 | EGF-like_CS |
| IPR000742 | EGF-like_dom |
| IPR000152 | EGF-type_Asp/Asn_hydroxyl_site |
| IPR018097 | EGF_Ca-bd_CS |
| IPR024731 | EGF_dom |
| IPR015915 | Kelch-typ_b-propeller |
| IPR002049 | Laminin_EGF |
| IPR002165 | Plexin_repeat |
| IPR016201 | PSI |
| IPR035914 | Sperma_CUB_dom_sf |