| Tag | Content |
|---|---|
| Uniprot ID | F1QBZ9 |
| Entrez ID | 791154 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005158031.3 |
| Ensembl protein ID | ENSDARP00000154980; ENSDARP00000118079; |
| Ensembl nucleotide ID | ENSDARG00000079751 |
| Gene name | Multiple EGF-like-domains 8 |
| Gene symbol | megf8 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTFHIQTLLL PVLVVLVPAV WAGDCKGQRQ VLRAVPGYVT DGPGNYSVNG NCEWLIMAPS 60 RNHRIVLNFM FIDTECTYDY LFVYDGDSYQ SPLLASLSGK TLPQPIEAKS GKMLLHLFSD 120 ANYNLLGFNA TYTFSVCPGD CSGHGRCDVA TARCQCQQGW GGLDCNTPLC SQACTQRGHG 180 ICDKRGLKCI CSSGFVGQDC QLGLRDNSGA GQWWEVSSGD VKAAPRTSSA GVYLASTGAM 240 YMFGGFDLNR ALEDLVVYNF STNSWEQMTF SHSPAPRHSH TAVEWQGSMV IYGGELANHS 300 LASDVWIYRP QQNEWQQLGL SDAPGAPRLA NHAAAIVDHY LYVFGGRTEE DMFSSSLYRF 360 RLRNGVWEAV QPTGGKPPAT AGHSMIYHSP SKTLLVYGGH RPTTARFSVR VNSTDAFHVE 420 KRFWTSFRSR FPANGPRERA FHSATVIGNY MVVYGGNVHI HYTEEKCYDE EIFFYHLGCH 480 QWVSVGDSLG QRGVSVRGRY SHVAAVMEGR VLLVAGGYSG IARGDLVAYK VPLFVSSDPG 540 DRDSVCAEAP SESLCLKNPE CSWCEGRCRE YQPTDPCGST GCLGLARFLS DCQSCLVFSG 600 VPNSLPRVSG EFGWCVQNES CLPVSEHSAC RVDQISGAYG WWGERTRFLT SLPFCRTENY 660 VPGLHLLTFQ HPRNQSQPDK VSILRSTSII LNPSTEMDVT LQFRGFIHPL WSSPPHQETV 720 AMWARIQKLH FTAQMAAGPN SLQLTDVLGR WSAQEEKDIH KLSRSDGSRL FQNLTRGNWY 780 LIQAEGYLNN SASGQTSEMA LTWNRTGLPG GSEISFLFLE PFRSNSCSEY RSCLACLSDQ 840 SCGWCPTVNL CFLRSDINQQ PCIDPQGEER HLLLNPLHCT LCEEYRDCAA CTQDPYCEWQ 900 INSSKKGDYL CSRRGRLEGS IREPGGCPNV CNQRLTCGEC LSNSSQCAWC ESAQSCFYFA 960 AYLTKFPYGE CRDWYDSVHS VPQCKQCTAL TTCSECLQTF QCGWCGDYSN PTIGRCLRGD 1020 WGGMNDHSAV NCSTAVAEVK ATSPEPQTLS PPRLMELEMD LEMEQLEGME GDGDAVWSYP 1080 SCPDVEECRL GLHTCHPSAT CVNTPTSYEC HCERGFTGDG VHHCNQTCYN ECRQGRCSGS 1140 PLFECECSLG WTSDPATLVL SGVECDVDCG CNFHSTCITA PGICDQCQDW TTGPHCEHCK 1200 PGSFGSALAR GDGCVPCQCN GHGDPLQGFC HNQTGQCYCT HHTQGPHCES CLPGYYGDPR 1260 DNGTCFSQCQ GRSVLLSSSV PLSLSSSLGW HGAVGGHGGV GGHGGLSHCL WVLSVSQDLA 1320 PCMPGQSCPP VALTWHPDSH THCTNSYVYV FDGLPRFLSN GVVHSHHNLI GAFCGTTRME 1380 PITVEATSGV VSVYFEANVT SGRAQGFNAS FWVKRCGNGS TDEGTVISAE CQAGAQCING 1440 LCECPHGLGG PQCDRPVCPG SCGAEEGRGT CNMNLGLCVC TEGWAGSDCS SISDTDSLVW 1500 ETLLDTQLSV NKAHRFLRRM GHSLMSSPQG TLWMYGGLSL SEGILGNVYR YSVADRRWTE 1560 VLTSSVEESS MPLPRYHHAS ALVYYQFPIS GSHSATRNLM FVVGGVTKEG VANDTWCLNL 1620 DSQEWKQYKS SVLPPVAGHT LTVRKGSSVL LIGGYSPENG FNHHLLEFSP QSGNWTIALH 1680 TGTPPTGLYG HSAVYHEQTD AVYVFGGYRF HVEAVEPSGE LYSLYYPNLT WSLLVPSQGN 1740 KPLSRFFHAA ALVKDTMVIV GGRTGEEDYS NTVSLYQINC NTWIQPVSSV GEPVNSSVSL 1800 AMTVWGDRLF LSGGFNGVTL GRFLTLSLPS DPCILLPTPE ACNSSTGSCV WCRGTCASSD 1860 AAERLGCTLG LSTCSPTPRS PDQCRRLKTC SECLARHPKT FSSPVQSALQ CKWCTNCPEG 1920 ACISSSVSCT SEHDCRINQR EIFLSSNCTE TSCEASDCPK CTASGKCMWT RQFKRTGETR 1980 RILSVNPTYD WTCFSYALLN VSPMQVESSP PMPCPEPCHE IKTCSQCLSS RGSDGGWQRC 2040 VWSMALQQCM SPSFVPLRCE AGQCGRLLSD EDSCSPQCFQ LTQCSQCISR PQCGWCAGRG 2100 GNGSGRCLQG GLNGVSEALC PQWNSSWSFL HCPEEDECSN GHHHCNVTQD CHDLPEGYHC 2160 TCRQGYVLSS VSGQCEPVCA QGCVNGTCIS PGICQCHFGF VGENCSSQCR CNKHSNCKSI 2220 SQLDTCLECK NNTKGQHCDK CKPLFVGSAM GGGMCRPCRE FCRGNSDICL SKDEHNKAME 2280 NPKDYPLDRE SIEQWATEGP TEDHAVCVSC QNNSVGDKCE SCLSGYFLLQ GKCEKCQCNG 2340 HADTCNEHDG TGCPCQNNTE TSSCLSSPQN DRKECYRQQC AKCKESFNGN PVNGRQCYRQ 2400 FNVDSECCFD PTSQVNCFHE PNIRNLLRGR TVFFSAQPKF TNVDIRVTID VTFGEVEVYV 2460 SNSHDTFIVQ VDRQSGVHTI KIEDEATSAT ASRGEKEVPL APPSPMKVFA NSSSALLGTL 2520 SAKLQGSERE VREERAEGLI TYITVWKPQT VLIVRGVRDR VVITFPHEVH SLKSSRFFIA 2580 LRGVGTETHN GESQGLLFLR QDQAHIDLFV FFSVFFSCFF LFLSVCVLLW KVKQFLDFRR 2640 EQRRHIQEMT KMASRPFAKL TVYLEPEEPQ LVYLPSAGGG SAVSLAHVRT GKLGGMVMGQ 2700 RGRPGALSYK HDPGTGTATH HHHHLALSGG NNGQHLPLHY LNAHHYAPSS TANPTSHHQH 2760 HYPSSHGSYQ HFCRSDPFLS QLMGFSYSSF KVGPITLEPT DDGMAGVATV LIQLPGGILA 2820 PNRACLGSAL VTLRQNLQEY CGHGGAGTHP GAGGGRKGLL GHQHLTTMAM |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MEGF8 | A0A452EQ38 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MEGF8 | 1954 | Q7Z7M0 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Megf8 | 269878 | P60882 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MEGF8 | A0A2I3S6U5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | MEGF8 | 100513862 | F1RGK2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Megf8 | 114029 | R9PXW3 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | megf8 | 791154 | F1QBZ9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005509 | calcium ion binding |
| GO:0009887 | animal organ morphogenesis |
| GO:0042074 | cell migration involved in gastrulation |
| GO:0007368 | determination of left/right symmetry |
| GO:0055113 | epiboly involved in gastrulation with mouth forming second |
| GO:0060972 | left/right pattern formation |
| GO:0009888 | tissue development |
| InterPro ID | InterPro Term |
|---|---|
| IPR000859 | CUB_dom |
| IPR001881 | EGF-like_Ca-bd_dom |
| IPR000742 | EGF-like_dom |
| IPR000152 | EGF-type_Asp/Asn_hydroxyl_site |
| IPR018097 | EGF_Ca-bd_CS |
| IPR024731 | EGF_dom |
| IPR011043 | Gal_Oxase/kelch_b-propeller |
| IPR009030 | Growth_fac_rcpt_cys_sf |
| IPR015915 | Kelch-typ_b-propeller |
| IPR002049 | Laminin_EGF |
| IPR002165 | Plexin_repeat |
| IPR016201 | PSI |
| IPR035914 | Sperma_CUB_dom_sf |