| Tag | Content |
|---|---|
| Uniprot ID | F1RGK2 |
| Entrez ID | 100513862 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_013988614.1; XM_005655874.2; |
| Ensembl protein ID | ENSSSCP00000003272 |
| Ensembl nucleotide ID | ENSSSCG00000003021 |
| Gene name | Multiple EGF like domains 8 |
| Gene symbol | MEGF8 |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MALGRALAAA LALSLAALGP LFLGAQAGDC KGQRQVLREA PGFVTDGAGN YSVNGNCEWL 60 IEAPSPQHRI LLDFLFLDTE CTYDYLFVYD GDSPRGPLLA SLSGSTRPLP IEASSGKMLL 120 HLFSDANYNL LGFNASFRFS LCPGGCRSHG QCQPPGVCVC EPGWGGPDCS LQECQAYCGS 180 HGTCASPLGP CRCEPGFLGR ACDLHLWENQ GAGWWHNVSA GDPAFSARIG AAGAFLSPPG 240 LLAVFGGQDL NRALGDLVLY NFSANTWERW DLTPAPAARH SHVAVAWAGS LVLMGGELAD 300 GSLTNDVWAF SPLGGGHWEL LAPPASSSSG PPGLAGHAAA LVDNIWLYVS GGRTQHDLFS 360 SGLFRFRLNS TSRGYWEQVI PAGGRPPAAT GHSMVFHAPS RALLVHGGHR PSTARFSVRV 420 NSTELFHVDR RVWTTLKGRD GLQGPRERAF HTASVLGNYM VVYGGNVHTH YQEEKCYEDG 480 IFFYHLGCHQ WVSGAELAPP GTPEGRAAPP SGRYSHVAAV LGGSVLLVAG GYSGRPRGDL 540 MAYKVPPFVF QAPAPDYHLD YCSMYTDHSV CSRDPECSWC QGACQAALPP GTPSGACPAA 600 SCLGLGRLLG DCQACLAFSS TAAPPRGPGA LGWCVHNESC LPRPEQARCR GEQISGTVGW 660 WGPAPVFVTS LEACVTQSFL PGLHLLTFQQ PPNASQPDKV LIVRSTTITL TPSAETDVSL 720 VYRGFIHPLL PGGPGGPGAE DVAVWARAQR LHVLARMARG PDTENMEEVG RWVAQQEKET 780 RRLQRPGSAR LFPLPGRGHK YAVEIRGQLN GSAGPGHSEL TLLWDRTGVP GGSEISFFFL 840 EPYRSSACAS YSSCLGCLAD QGCGWCLTSS TCHLRQSGAH CGDDGAGGSL LVLVPALCPL 900 CEEHRDCHAC TQDPFCEWHQ STSRKGDAAC SRRGRGRGAL KSPEECPPLC SQRLTCDDCL 960 ANSSQCAWCQ STHTCFMFAA YLARYPHGGC RGWDDSVHSE PRCRSCDRFL TCHECLQSHE 1020 CGWCGNEDNP TLGRCLQGDF SGPLGGGNCS LWVGEGLGLS VALPARWAYA RCPDVDECRL 1080 GLARCHLRAT CLNTPLSYEC HCQRGYQGDG ITYCNRTCLE DCGHGVCSGP PDFTCVCDLG 1140 WTSDLPLPTP APGPPAPRCS RDCGCNFHSH CRKRGPGFCD ECQDWTWGEH CERCRPGSFG 1200 NATGSGGCRP CQCNGHGDPR RGHCDNLSGL CFCQDHTEGA HCQLCSPGYY GDPRAGGSCF 1260 RECGGRALLT NVSSVALGSR RVGGLLPAGG GAARAGPGLS YCVWVVSATE VLQPCAPGTL 1320 CPPLTLTFSP DSSTPCTLSY VLAFDGFPRF LDTGVIQSDR SLIAAFCGQR RDRPLTVQAL 1380 SGLLVLHWEA NGSSSWGFNA SVGSARCGSG GPGSCPVPQE CVPQDGVTGA GLCQCPQGWA 1440 GPHCRMALCP ENCNAHNGAG TCNQSLGVCI CAEGFGGPDC ATKLDGGQLV WETLMDSRLS 1500 ADTASRFLHR LGHTMVEGPD ATLWMFGGLG LPQGLLGNLY RYSVSERRWT QMLAGAEDGG 1560 PGPSPRSFHA AAYVPAGRGA MYLLGGLTAG GVARDFWVLN LTTLQWRQEK APQTVELPAV 1620 AGHTLTPRRG LSLLLVGGYS PENGFNQQLL EYQLATGTWV SGAQSGTPPT GLYGHSAVYH 1680 EATDSLYVFG GFRFHVELAA PSPELYSLHC PDRTWSLLAP SQGAKPRPRL FHASALLGDT 1740 MVVLGGRSDP DEFSSDVLLY QVNCNTWLLP DLIRPASVGP PMEESVAHAV AAVGGRLYIS 1800 GGFGGVALGR LLALTLPPDS CRLLPSPEAC NQSGACIWCH GACLSGDQAH RLGCGGSPCS 1860 PMPHSPEECR RLRTCSECLA RHPRTLQPGD GEAPAPRCKW CTNCPEGACI GRNGSCTSEN 1920 DCRINQREVF WAGNCSEAVC GAADCEQCTR EGKCMWTRQF KRTGETRRIL SVQPTYDWTC 1980 FSHSLLNVSP MPVESSPPLP CPTPCHLLPN CTSCLDSKGA DGGWQHCVWS SSLQQCLSPS 2040 YLPLRCMAGG CGRLLRGPES CSLGCAQATQ CALCLRRPHC GWCAWGSQDG GGHCLEGGLS 2100 GPRDGLTCGR PGASWAFLSC PPEDECANGH HDCNETQNCH DRPHGYECSC KTGYTMDNVT 2160 GLCRPVCAQG CVNGSCVEPD HCRCHFGFVG RNCSTECRCN RHSECAGVGA RDHCLLCHNH 2220 TKGSHCEQCL PLFVGSAVGG GTCRPCHAFC RGNSHVCLSR KELEMARREP EKYSLDPDKI 2280 ENWVSEGPSE DEAVCVNCQN NSYGDKCESC LHGYFLLEGK CTKCQCNGHA DTCNEQDGTG 2340 CPCQNNTETG TCQGSSPSDR RDCYKYQCAK CRESFHGSPL GGQQCYRLIS VEQECCLDPT 2400 SQTNCFHEPK RRALGPGRTV LFGVQPKFTN VDIRLTLDVT FGAVDLYVST SYDTFVVRVA 2460 PDTGVHTVHI QPPPPPPPPP PPADGGPRGA GDLGGPGTGG GPATPVEPRV REVWPRGLIT 2520 YVTVTEPSAV LVVRGVRDRL VITYPHEYHT LKSSRFYLLL LGVGDPSGPS ANGSADSQGL 2580 LFFRQDQAHI DLFVFFSVFF SCFFLFLSLC VLLWKAKQAL DQRQEQRRHL QEMTKMASRP 2640 FAKVTVCFPP DPTAPALAWK PAGLPPPTFR RSEPFLAPLL LTGAGGPWGP VGGGCCPPAI 2700 PATTAGLRAG PITLEPTEDG MAGVATLLLQ LPGGPHAPNG ACLGSALVTL RHRLHEYCGG 2760 GGGAGGSGHG AGAGRKGLLS QDNLTSMSL 2789 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MEGF8 | A0A452EQ38 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MEGF8 | 1954 | Q7Z7M0 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Megf8 | 269878 | P60882 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MEGF8 | A0A2I3S6U5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | MEGF8 | 100513862 | F1RGK2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Megf8 | 114029 | R9PXW3 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | megf8 | 791154 | F1QBZ9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005634 | nucleus |
| GO:0005509 | calcium ion binding |
| GO:0009887 | animal organ morphogenesis |
| GO:0030509 | BMP signaling pathway |
| GO:0042074 | cell migration involved in gastrulation |
| GO:0060976 | coronary vasculature development |
| GO:0097094 | craniofacial suture morphogenesis |
| GO:0071907 | determination of digestive tract left/right asymmetry |
| GO:0061371 | determination of heart left/right asymmetry |
| GO:0060971 | embryonic heart tube left/right pattern formation |
| GO:0003143 | embryonic heart tube morphogenesis |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0055113 | epiboly involved in gastrulation with mouth forming second |
| GO:0097155 | fasciculation of sensory neuron axon |
| GO:0060972 | left/right pattern formation |
| GO:0045879 | negative regulation of smoothened signaling pathway |
| GO:0048842 | positive regulation of axon extension involved in axon guidance |
| GO:0010468 | regulation of gene expression |
| GO:0009888 | tissue development |
| InterPro ID | InterPro Term |
|---|---|
| IPR000859 | CUB_dom |
| IPR001881 | EGF-like_Ca-bd_dom |
| IPR013032 | EGF-like_CS |
| IPR000742 | EGF-like_dom |
| IPR000152 | EGF-type_Asp/Asn_hydroxyl_site |
| IPR018097 | EGF_Ca-bd_CS |
| IPR009030 | Growth_fac_rcpt_cys_sf |
| IPR015915 | Kelch-typ_b-propeller |
| IPR002049 | Laminin_EGF |
| IPR002165 | Plexin_repeat |
| IPR016201 | PSI |
| IPR035914 | Sperma_CUB_dom_sf |