| Tag | Content |
|---|---|
| Uniprot ID | P60882; B3GR00; Q80TR3; Q80V41; Q8BMN9; Q8JZW7; Q8K0J3; |
| Entrez ID | 269878 |
| Genbank protein ID | AAH51121.1; ACE00231.1; AAH60277.1; AAH36727.1; BAC26949.1; BAC65659.1; AAH31185.1; |
| Genbank nucleotide ID | NM_001160400.1 |
| Ensembl protein ID | ENSMUSP00000122192 |
| Ensembl nucleotide ID | ENSMUSG00000045039 |
| Gene name | Multiple epidermal growth factor-like domains protein 8 |
| Gene symbol | Megf8 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 25807483 |
| Functional description | Acts as a negative regulator of hedgehog signaling (PubMed:29290584). |
| Sequence | MALGGALALA LALALAVLGP LSLRVLAGDC KGQRQVLREA PGFVTDGAGN YSVNGNCEWL 60 IEAPSPQHRI LLDFLFLDTE CTYDYLFVYD GDSPQGPLLA SLSGSTRPPP IEASSGKMLL 120 HLFSDANYNL LGFNASFRFS LCPGGCQNHG QCKSPGVCVC EPGWGGPDCG LQECSAYCGS 180 HGTCASTLGP CRCEPGFLGR ACDLHLWENQ GAGWWHSVSA GDPAFSARIG AAGAFLSPPG 240 LLAVFGGQDL NKALGDLVLY NFSTNTWESW DLTPAPAARH SHVAVAWAGL LVLMGGELAN 300 GLLTNDVWAF SPLGGGHWEL LAPPASSSSG PPGLAGHAAA LVDDIWLYVS GGRTQHDLFS 360 SGLFRFRLDH TSRGYWEQVI PAGGRPPAAT GHSMVFHAPS RTLLVHGGHR PSTARFSVRV 420 NSTELFHVER RVWTTLKGRD GLQGPRERAF HTASVLGNYM VVYGGNVHTH YQEEKCYEDG 480 IFFYHLGCHQ WVSGAELAPP GTPEGRAAPP SGRYSHVAAV LGGSVLLVAG GYSGRPRGDL 540 MAYKVPPFVF QAPALDYHLD YCSMYTDHSV CSRDPECSWC QGACQAAPPP GTPSGACPAA 600 SCLGLGRLLS DCQACLAFSS PTAPPRGPGA LGWCVHNESC LPRPEQARCR GEQISGTVGW 660 WGPAPVFVTS LEACVTQSFL PGLHLLTFQQ PPNASQPDKV SIVRSTTITL TPSPETDVSL 720 VYRGFIHPLL PGGPGGPGAE DVAVWARAQR LHVLARMARG PDTENMEEVG RWVAQQEKET 780 RRLQRPGSDR LFPLPGRGNK YAVEIRGQLN GSAGPGHSEL TLLWDRTGVP GGSEISFFFL 840 EPYRSSACTS YSSCLGCLAD QGCGWCLNSA TCHLRQGRAH CEDDGSGESL LVLVPALCPL 900 CEEHRDCHAC TQDPFCEWHQ STNRKGDAAC SRRGRGRGAL KNPEECPPLC SQRLTCEDCL 960 ANSSQCAWCQ STHTCFLFAA YLARYPHGGC RGWDDSVHSE PRCRSCGGFL TCHECLQSHE 1020 CGWCGNEDNP TLGRCLQGDF SGPLGGGNCS LWVGEGLGLP VALPARWAYA RCPDVDECRL 1080 GLARCHPRAT CLNTPLSYEC HCQRGYQGDG ITHCNRTCLE DCGHGVCSGP PDFTCVCDLG 1140 WTSDLPPPTP APGPPAPRCS RDCGCSFHSH CRRRGPGYCD ECQDWTWGEH CERCRPGSFG 1200 NATGSGGCRP CQCNGHGDPR RGHCDNLTGL CFCQDHTEGA HCQICSPGYY GDPRAGGSCF 1260 RECGGRALLT NVSSVALGSR RFGGLLPPGG GAARAGPGLS YCVWVVSATE ALQPCVPGTL 1320 CPPLTLTFSP DSSTPCTLSY VLAFDGFPRF LDTGVVQSDR SLIAAFCGQR RDRPLTVQAL 1380 SGLLVLHWEA NGSSSWGFNA SVGSARCGSG GPGSCPVPQE CVPQDGAAGA GLCRCPQGWA 1440 GPHCRMALCP ENCNAHTGAG ICNQSLGVCI CAEGFGGPDC ATKLDGGQLV WETLMDSRLS 1500 ADTASRFLHR LGHTMVEGPD ATLWMFGGLG LPQGLLGNLY RYSVSERRWT QMLAGAEDGG 1560 PGPSPRSFHA AAYVPAGRGA MYLLGGLTAG GVTRDFWVLN LTTLQWRQEK PPQNMELPAV 1620 AGHTLTARRG LSLLLVGGYS PENGFNQQLL EYQLATGTWV SGAQSGTPPT GLYGHSAVYH 1680 EATDSLYVFG GFRFHVELAA PSPELYSLHC PDRTWSLLAP SQGAKPRPRL FHASALLGDT 1740 MVVLGGRSDP DEFSSDVLLY QVNCNTWLLP ALTRPAFVGS PMEESVAHAV AAVGSRLYIS 1800 GGFGGVALGR LLALTLPPDP CRLLPSPEAC NQSGACTWCH GACLSGDQAH RLGCGVPPCS 1860 PMPRSPEECR RLRTCSECLA RHPRTLQPGD GEASIPRCKW CTNCPEGACI GRNGSCTSEN 1920 DCRINQREVF WAGNCSEAAC GAADCEQCTR EGKCMWTRQF KRTGETRRIL SVQPTYDWTC 1980 FSHSLLNVSP MPVESSPPLP CPTPCHLLPN CTSCLASKGA DGGWQHCVWS SSLQQCLSPS 2040 YLPLRCMAGG CGRLLRGPES CSLGCAQATQ CALCLRRPHC GWCAWGGQDG GGHCMEGGLS 2100 GPRDGLTCGR PGASWAFLSC PPEDECANGH HDCNETQNCH DQPHGYECSC KTGYTMDNVT 2160 GVCRPVCAQG CVNGSCVEPD HCRCHFGFVG RNCSTECRCN RHSECAGVGA QDHCLLCRNH 2220 TKGSHCEQCL PLFVGSALGG GTCRPCHAFC RGNSHVCVSR KELEMARKEP EKYSLDPEEI 2280 ETWVAEGPSE DEAVCVNCQN NSYGDRCESC LHGYFLLDGK CTKCQCNGHA DTCNEQDGTG 2340 CPCQNNTETG TCQGSSPSDR RDCYKYQCAK CRESFHGSPL GGQQCYRLIS VEQECCLDPT 2400 SQTNCFHEPK RRALGPGRTV LFGVQPKFTN VDIRLTLDVT FGAVDLYVST SYDTFVVRVA 2460 PDTGVHTVHI QPPPPPPPPP PPADGVPRVA ADLGGLGTGS GSGSPVEPRV REVWPRGLIT 2520 YVTVTEPSAV LVVRSVRDRL VITYPHEHHA LKSSRFYLLL LGVGDPNGPG ANGSADSQGL 2580 LFFRQDQAHI DLFVFFSVFF SCFFLFLSLC VLLWKAKQAL DQRQEQRRHL QEMTKMASRP 2640 FAKVTVCFPP DPAGPAPAWK PAGLPPPAFR RSEPFLAPLL LTGAGGPWGP MGGGCCPPAL 2700 PATTAGLRAG PITLEPTEDG MAGVATLLLQ LPGGPHAPNG ACLGSALVTL RHRLHEYCGG 2760 SGGAGGSGHG GGGGRKGLLS QDNLTSMSL 2789 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MEGF8 | A0A452EQ38 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MEGF8 | 1954 | Q7Z7M0 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Megf8 | 269878 | P60882 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MEGF8 | A0A2I3S6U5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | MEGF8 | 100513862 | F1RGK2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Megf8 | 114029 | R9PXW3 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | megf8 | 791154 | F1QBZ9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003674 | molecular_function | ND |
| GO:0005509 | calcium ion binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003143 | embryonic heart tube morphogenesis | IMP |
| GO:0007368 | determination of left/right symmetry | IMP |
| GO:0009887 | animal organ morphogenesis | IBA |
| GO:0009888 | tissue development | IBA |
| GO:0010468 | regulation of gene expression | IMP |
| GO:0030326 | embryonic limb morphogenesis | IMP |
| GO:0030509 | BMP signaling pathway | IGI |
| GO:0035108 | limb morphogenesis | ISO |
| GO:0042074 | cell migration involved in gastrulation | ISO |
| GO:0045879 | negative regulation of smoothened signaling pathway | IMP |
| GO:0048704 | embryonic skeletal system morphogenesis | IMP |
| GO:0048842 | positive regulation of axon extension involved in axon guidance | IMP |
| GO:0055113 | epiboly involved in gastrulation with mouth forming second | ISO |
| GO:0060971 | embryonic heart tube left/right pattern formation | IMP |
| GO:0060972 | left/right pattern formation | ISO |
| GO:0060972 | left/right pattern formation | IMP |
| GO:0060976 | coronary vasculature development | IMP |
| GO:0061371 | determination of heart left/right asymmetry | ISO |
| GO:0061371 | determination of heart left/right asymmetry | IMP |
| GO:0071907 | determination of digestive tract left/right asymmetry | IMP |
| GO:0097094 | craniofacial suture morphogenesis | ISO |
| GO:0097155 | fasciculation of sensory neuron axon | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IDA |
| GO:0016021 | integral component of membrane | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|
| InterPro ID | InterPro Term |
|---|---|
| IPR000859 | CUB_dom |
| IPR001881 | EGF-like_Ca-bd_dom |
| IPR013032 | EGF-like_CS |
| IPR000742 | EGF-like_dom |
| IPR000152 | EGF-type_Asp/Asn_hydroxyl_site |
| IPR018097 | EGF_Ca-bd_CS |
| IPR024731 | EGF_dom |
| IPR015915 | Kelch-typ_b-propeller |
| IPR002049 | Laminin_EGF |
| IPR002165 | Plexin_repeat |
| IPR016201 | PSI |
| IPR035914 | Sperma_CUB_dom_sf |