| Tag | Content |
|---|---|
| Uniprot ID | R9PXW3 |
| Entrez ID | 114029 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_053628.2 |
| Ensembl protein ID | ENSRNOP00000074834 |
| Ensembl nucleotide ID | ENSRNOG00000052687 |
| Gene name | Multiple epidermal growth factor-like domains protein 8 |
| Gene symbol | Megf8 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MALGGALAAA LALAFAVLGP LSHKVLAGDC KGQRQVLREA PGFVTDGAGN YSVNGNCEWL 60 IEAPSPQHRI LLDFLFLDTE CTYDYLFVYD GDSPQGPLLA SLSGSTRPPP IEASSGKMLL 120 HLFSDANYNL LGFNASFRFS LCPGGCQNHG QCKSPGVCVC EPGWGGPDCG LQECSAYCGS 180 HGTCASTLGP CRCEPGFLGR ACDLHLWENQ GAGWWHSVSA GDPAFSARVG AAGAFLSPPG 240 LLAVFGGQDL NKALGDLVLY NFSTNTWESW DLTPAPAARH SHVAVAWAGF LVLMGGELAN 300 GLLTNDVWAF SPLGGGHWEL LAPPASSSSG PPGLAGHAAA LVDDIWLYVS GGRTQHDLFS 360 SGLFRFRLDH TSRGYWEQVI PAGGRPPAAT GHSMVFHAPS RTLLVHGGHR PSTARFSVRV 420 NSTELFHVDR RVWTTLKGRD GLQGPRERAF HTASVLGNYM VVYGGNVHTH YQEEKCYEDG 480 IFFYHLGCHQ WVSGAELAPP GTPEGRAAPP SGRYSHVAAV LGGSVLLVAG GYSGRPRGDL 540 MAYKVPPFVF QAPALDYHLD YCSMYTDHSV CSRDPECSWC QGACQSAPPP GTPSGACPAA 600 SCLGLGRLLS DCQACLAFSS PTAPPRGPGT LGWCVHNESC LPRPEQARCR GEQISGTVGW 660 WGPAPVFVTS LEACVTQSFL PGLHLLTFQQ PPNASQPDKV SIVRSTTITL TPSAETDVSL 720 VYRGFIYPML PGGPGGPGAE DVAVWARAQR LHVLARMARG PDTENMEEVG RWVAQQEKET 780 RRLQRPGSSR LFPLPGRGNK YAVEIRGQLN GSAGPGHSEL TLLWDRTGVP GGSEISFFFL 840 EPYRSLACSS YSSCLGCLAD QGCGWCLNSA TCHLRQGRAH CEDDGNGESL LVLVPALCPL 900 CEEHRDCHAC TQDPFCEWHQ STNRKGDAAC SRRGRGRGAL KNPEECPPLC SQRLTCEDCL 960 ANSSQCAWCQ STHTCFLFAA YLARYPHGGC RGWDDSVHSE PRCRSCHGFL TCHECLQSHE 1020 CGWCGNEDNP TLGRCLQGDF SGPLGGGNCS LWVGEGLGLP VALPARWAYA RCPDVDECRL 1080 GLARCHPRAT CLNTPLSYEC HCQRGYQGDG ITHCNRTCLE DCGHGVCSGP PDFTCVCDLG 1140 WTSDLPPPTP APGPPAPRCS RDCGCNFHSH CRRRGPGYCD ECQDWTWGEH CERCRPGSFG 1200 NATGSGGCRP CQCNGHGDPR RGHCDNLSGL CFCQDHTEGA HCQICSPGYY GDPRAGGSCF 1260 RECGGRALLT NVSSVALGSR RFGGLLPPGG GTARAGPGLS YCVWVVSATE ALQPCAPGTL 1320 CPPLTLTFSP DSSTPCTLSY VLAFDGFPRF LDTGVVQSDR SLIAAFCGQR RDRPLTVQAL 1380 SGLLVLHWEA NGSSSWGFNA SVGSARCGSG GPGSCPVPQE CVPQDGAAGA GLCRCPQGWA 1440 GPHCRMALCP ENCNAHTGAG ICNQSLGVCI CAEGFGGPDC ATKLDGGQLV WETLMDSRLS 1500 ADTASRFLHR LGHTMVEGPD ATLWMFGGLG LPQGLLGNLY RYSVSERRWT QMLAGAEDGG 1560 PGPSPRSFHA AAYVPAGRGA MYLLGGLTAG GITCDFWVLN LTTLQWRQEK APQSIELPAV 1620 AGHTLTARRG LSLLLVGGYS PENGFNQQLL EYQLATGTWV SGAQSGTPPT GLYGHSAVYH 1680 EATDSLYVFG GFRFHVELAA PSPELYSLHC PDRTWSLLAP SQGAKPRPRL FHASALLGDT 1740 MVVLGGRSDP DEFSSDVLLY QVNCNTWLLP DLTRPAFVGS PMEESVAHAV AAVGSRLYIS 1800 GGFGGVALGR LLALTLPPDP CRLLPSPEAC NQSGACTWCH GACLSGDQAH RLGCGVPPCS 1860 PMPRSPEECR RLRTCSECLA RHPRTLQPGD GEASVPRCKW CTNCPEGACI GRNGSCTSEN 1920 DCRINQREVF WAGNCSEAAC GAADCEQCTR EGKCMWTRQF KRTGETRRIL SVQPTYDWTC 1980 FSHSLLNVSP MPVESSPPLP CPTPCHLLPN CTSCLASKGA DGGWQHCVWS SSLQQCLSPS 2040 YLPLRCMAGG CGRLLRGPES CSLGCAQATQ CALCLRRPHC GWCAWGGQDG GGHCMEGGLS 2100 GPRDGLTCGR PGASWAFLSC PPEDECANGH HDCNETQNCH DQPHGYECSC KTGYTMDNVT 2160 GVCRPVCAQG CVNGSCVEPD HCRCHFGFVG RNCSTECRCN RHSECAGVGA RDHCLLCRNH 2220 TKGSHCEQCL PLFVGSALGG GTCRPCHAFC RGNSHVCVSR KELEMARREP EKYSLDPEEI 2280 EAWVAEGPSE DEAVCVNCQN NSYGDRCESC LHGYFLLDGK CTKCQCNGHA DTCNEQDGTG 2340 CPCQNNTETG VCQGSSPSDR RDCYKYQCAK CRESFHGSPL GGQQCYRLIS VEQECCLDPT 2400 SQTNCFHEPK RRALGPGRTV LFGVQPKFTN VDIRLTLDVT FGAVDLYVST SYDTFVVRVA 2460 PDTGVHTVHI QPPPPPPPPP PPADGVPRVA SDLGGLGTGS GSGSPVEPRV REVWPRGLIT 2520 YVTVTEPSAV LVVRSVRDRL VITYPHEHHA LKSSRFYLLL LGVGDPNGPG ANGSADSQGL 2580 LFFRQDQAHI DLFVFFSVFF SCFFLFLSLC VLLWKAKQAL DQRQEQRRHL QEMTKMASRP 2640 FAKVTVCFPP DPAGPAPAWK PAGLPPPAFR RSEPFLAPLL LTGAGGPWGP MGGGCCPPAL 2700 PATTAGLRAG PITLEPTEDG MAGVATLLLQ LPGGPHAPNG ACLGSALVTL RHRLHEYCGG 2760 SGGAGGSGHG GGGGRKGLLS QDNLTSMSL 2789 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MEGF8 | A0A452EQ38 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MEGF8 | 1954 | Q7Z7M0 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Megf8 | 269878 | P60882 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MEGF8 | A0A2I3S6U5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | MEGF8 | 100513862 | F1RGK2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Megf8 | 114029 | R9PXW3 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | megf8 | 791154 | F1QBZ9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005634 | nucleus |
| GO:0005509 | calcium ion binding |
| GO:0030509 | BMP signaling pathway |
| GO:0042074 | cell migration involved in gastrulation |
| GO:0060976 | coronary vasculature development |
| GO:0097094 | craniofacial suture morphogenesis |
| GO:0071907 | determination of digestive tract left/right asymmetry |
| GO:0061371 | determination of heart left/right asymmetry |
| GO:0060971 | embryonic heart tube left/right pattern formation |
| GO:0003143 | embryonic heart tube morphogenesis |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0055113 | epiboly involved in gastrulation with mouth forming second |
| GO:0097155 | fasciculation of sensory neuron axon |
| GO:0045879 | negative regulation of smoothened signaling pathway |
| GO:0048842 | positive regulation of axon extension involved in axon guidance |
| InterPro ID | InterPro Term |
|---|---|
| IPR000859 | CUB_dom |
| IPR001881 | EGF-like_Ca-bd_dom |
| IPR013032 | EGF-like_CS |
| IPR000742 | EGF-like_dom |
| IPR000152 | EGF-type_Asp/Asn_hydroxyl_site |
| IPR018097 | EGF_Ca-bd_CS |
| IPR024731 | EGF_dom |
| IPR015915 | Kelch-typ_b-propeller |
| IPR002049 | Laminin_EGF |
| IPR002165 | Plexin_repeat |
| IPR016201 | PSI |
| IPR035914 | Sperma_CUB_dom_sf |