| Tag | Content |
|---|---|
| Uniprot ID | A0A452EQ38 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000013868 |
| Ensembl nucleotide ID | ENSCHIG00000015019 |
| Gene name | Uncharacterized protein |
| Gene symbol | MEGF8 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MALGRALAVA LAISLAVLGP LSPGAQAGDC KGQRQVLREA PGFVTDGAGN YSVNGNCEWL 60 IEAPSSQHRI LLDFLFLDTE CTYDYLFVYD GDSPRGPLLA SLSGSTRPLP IEASSGKMLL 120 HLFSDANYNL LGFNASFRFS LCPGGCHSHG QCRPPGVCVC EPGWGGPDCG LQECSAYCGS 180 HGTCASPLGP CRCEPGFLGR ACDLHLWENQ GAGWWHNVSA GDPAFSARIG AAGAFLSPPG 240 LLAVFGGQDL NRALGDLVLY NFSANTWERW DLSPAPAARH SHVAVAWAGS LVLMGGELAD 300 GTLTSDIWAF SPMGGGRWEL LAPPASSPSG PPGLAGHAAA LVDNTWLYVS GGRTQHDLFS 360 SGLFRFRLDS TSGGYWEQVM PAGGRPPAAT GHSMVFHAPS RALLVHGGHR PSTARFSVRV 420 NSTELFHVDQ RVWTTLKGRE GLQGPRERAF HTASVLGNYM LVYGGNVHTH YQEEKCYEDG 480 IFFYHLGCHQ WVSGAELAPP GTPEGRAAPP SGRYSHVAAV LGGSVLLVAG GYSGRPRGDL 540 MAYKVPPFVF QAPAPDYHLD YCSMYTDHSV CSRDPECSWC QGACQAAPPP GTPSGACLAA 600 SCLGLSRLLG DCQACLAFSS SAAPPRGPGA LGWCVHNESC LPRPEQARCR GEQISGTVGW 660 WGPAPVFVTS LEACVTQSFL PGLHLLTFQQ PPNASQPDKV LIVRSTTITL TPSSETDVSL 720 VYRGFIHPLL PGGPGGSGAE DVAVWARAQR LHVLARMARG PDAENMEEVG RWVAQQEKET 780 RRLQRPGSAR LFPLPGRGHK YAVEIRGQLN GSAGPGHSEL TLLWDRTGVP GGSEISFFFL 840 EPYRSSACAS YSSCLGCLAD QGCGWCLASA TCHLRQSGAH CGDAGAGGSL LVLVPALCPL 900 CEEHRDCHAC TQDPFCEWHQ STSRKGDAAC SRRGRGRGAL KSPEECPPLC SQRLTCDDCL 960 ANSSQCAWCQ STRTCFLFAA YLARYPHGGC RGWDDSVHSE PRCRSCDRFP SCHECLQSHE 1020 CGWCGNEDNP TLGRCLQGDF SGPLSGGNCS LWVGEGLGLS VALPARWAYA RCPDVDECRL 1080 GLARCHLRAT CLNTPLSYEC HCQRGYQGDG VTYCNRTCLE DCGHGVCSGP PDFTCVCDLG 1140 WTSDLPPPTP APGPPAPRCS RDCGCNFHSH CHKRGPGFCD ECQDWTWGEH CERCRPGSFG 1200 NATGSGGCRP CQCNGHGDPR RGHCDNLSGL CFCQDHTEGA HCQLCSPGYY GDPRAGGSCF 1260 RECGGRALLT NVSSVALGSR RFGGLLPAGG GAARAGPGLS YCVWVVSATE VLQPCAPGTL 1320 CPPLTLTFSP DSSTPCTLSY VLAFDGFPRF LDTGVVQSDR SLIAAFCGQR RDRPLTVQAL 1380 SGLLVLHWEA NGSSSWGFNA SVGSARCGSG GPGSCPVPQE CVPQDGVPGG GLCRCPQGWA 1440 GPHCRMAVCP ENCNAHNGAG TCNQSLGVCV CAEGFGGPDC ATKLDGGQLV WETLMDSRLS 1500 ADTASRFLHR LGHTMVEGPD ATLWIGGMLP QGAAFWHLGP RYSVSERRWT QMLAGAEDGG 1560 PGPSPRSFHA AAYVPAGRGA MYLLGGLTAG GVSRDFWVLN LTTLQWRQEK APQTVELPAV 1620 AGHTLTARRG LSLLLVGGYS PENGFNQQLL EYQLATGTWV SGAQSGTPPT GLYGHSAVYH 1680 EATDSLYVFG GFRFHVELAA PSPELYSLHC PDRTWSLLAP SQGAKVRKKE TRGSSQAIQA 1740 GFLGNNMGHE GSRGSQKGDG SWVPPCRVFS QQPRPRLFHA SALLGDTMVV LGGRSDPDEF 1800 SSDVLLYQVN CNTWLLPDLI GPASVGPPME ESVAHAVAAV GGRLFISGGF GGVALGRLLV 1860 LSLPPDPCRL LPSPEACNQT GACTWCHGAC LSGDQAHRLG CGGAPCSPMP RSPEECRRLR 1920 TCSECLARHP RTLQPGDGEA AAPRCKWCTN CPEGACIGRN GSCTSENDCR INQREVFWAG 1980 NCSEAVCGAA DCAQCTREGK CMWTRQFKRT GETRRILSVQ PTYDWTCFSH SLLNVSPMPV 2040 ESSPPLPCPT PCHLLPNCTS CLDSKGADGG WQHCVWSSSL QQCLSPSYLP LRCMAGGCGR 2100 LLRGPESCSL GCAQATQCAL CLRRPHCGWC TWGAQDGGGR CLEGGLSGPR DGLTCGRPGA 2160 SWAFLSCPPE DECANGHHDC NETQNCHDRP HGYECSCKAG YTMDNVTGLC RPVCAQGCVN 2220 GSCVEPDHCR CHFGFVGRNC STECRCNRHS DCAGVGARDH CLLCHNHTKG SHCEQCLPLF 2280 VGSAVGGGTC RPCHAFCRGN SHVCVSRKEL EIARREPEKY SLDPDEIEQW VTEGPSEDEA 2340 VCVHCQNNSY GDKCESCLHG YFLLDGKCTK CQCNGHADTC NEQDGTGCPC QNNTETGTCQ 2400 GSSPSDRRDC YKYQCAKCRE SFHGSPLGGQ QCYRLISVEQ EYCLDPTSQT NCFHEPKRRA 2460 LGPGRTVLFG VQPKFTNVDI RLTLDVTFGA VDLYVSTSYD TFVVRVAPDT GVHTVHIQPP 2520 PPPPPPPPPA DGGPRGPGDL GGPGAGGGLA TSAEPRVREV WPRGLITYVT VTEPSAVLVV 2580 RGVRDRLVIT YPHEHHTLKS SRFYLLLLGV GDPSGPSANG SADSQGLLFF RQDQAHIDLF 2640 VFFSVFFSCF FLFLSLCVLL WKAKQALDHR QEQRRHLQEM TKMASRPFAK VTVCFPPDPA 2700 APAPAWKPAG LPPPAFRRSE PFLAPLLLTG AGGPWGPVGG GCCPPAIPTT TAGLRAGPIT 2760 LEPTEDGMAG VATLLLQLPG GPHAPNGACL GSALVTLRHR LHEYCGGGGG AGGSGHGAGA 2820 GRKGLLSQDN LTSMSL 2836 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MEGF8 | A0A452EQ38 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MEGF8 | 1954 | Q7Z7M0 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Megf8 | 269878 | P60882 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MEGF8 | A0A2I3S6U5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | MEGF8 | 100513862 | F1RGK2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Megf8 | 114029 | R9PXW3 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | megf8 | 791154 | F1QBZ9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005634 | nucleus |
| GO:0005509 | calcium ion binding |
| GO:0030509 | BMP signaling pathway |
| GO:0042074 | cell migration involved in gastrulation |
| GO:0060976 | coronary vasculature development |
| GO:0097094 | craniofacial suture morphogenesis |
| GO:0071907 | determination of digestive tract left/right asymmetry |
| GO:0061371 | determination of heart left/right asymmetry |
| GO:0060971 | embryonic heart tube left/right pattern formation |
| GO:0003143 | embryonic heart tube morphogenesis |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0055113 | epiboly involved in gastrulation with mouth forming second |
| GO:0097155 | fasciculation of sensory neuron axon |
| GO:0045879 | negative regulation of smoothened signaling pathway |
| GO:0048842 | positive regulation of axon extension involved in axon guidance |
| InterPro ID | InterPro Term |
|---|---|
| IPR000859 | CUB_dom |
| IPR001881 | EGF-like_Ca-bd_dom |
| IPR013032 | EGF-like_CS |
| IPR000742 | EGF-like_dom |
| IPR000152 | EGF-type_Asp/Asn_hydroxyl_site |
| IPR018097 | EGF_Ca-bd_CS |
| IPR011043 | Gal_Oxase/kelch_b-propeller |
| IPR015915 | Kelch-typ_b-propeller |
| IPR002049 | Laminin_EGF |
| IPR002165 | Plexin_repeat |
| IPR016201 | PSI |
| IPR035914 | Sperma_CUB_dom_sf |