| Tag | Content |
|---|---|
| Uniprot ID | A0A2I3SZ08; A0A2J8QDK9; |
| Entrez ID | 453339 |
| Genbank protein ID | JAA23893.1; JAA19044.1; JAA33494.1; JAA09888.1; |
| Genbank nucleotide ID | XM_001144621.5; XM_016927950.1; |
| Ensembl protein ID | ENSPTRP00000082225 |
| Ensembl nucleotide ID | ENSPTRG00000006926 |
| Gene name | DNA repair protein RAD51 homolog |
| Gene symbol | RAD51 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. |
| Sequence | MAMQMQLEAN ADTSVEEESF GPQPISRLEQ CGINANDVKK LEEAGFHTVE AVAYAPKKEL 60 INIKGISEAK ADKILAEAAK LVPMGFTTAT EFHQRRSEII QITTGSKELD KLLQGGIETG 120 SITEMFGEFR TGKTQICHTL AVTCQLPIDR GGGEGKAMYI DTEGTFRPER LLAVAERYGL 180 SGSDVLDNVA YARAFNTDHQ TQLLYQASAM MVESRYALLI VDSATALYRT DYSGRGELSA 240 RQMHLARFLR MLLRLADEFG VAVVITNQVV AQVDGAAMFA ADPKKPIGGN IIAHASTTRL 300 YLRKGRGETR ICKIYDSPCL PEAEAMFAIN ADGVGDAKD 339 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RAD51 | 514749 | Q2KJ94 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 403568 | Q8MKI8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 102177525 | A0A452G921 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 5888 | Q06609 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Rad51 | 19361 | Q08297 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 453339 | A0A2I3SZ08 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 100141309 | B0M1M6 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 100008661 | G1TCL3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Rad51 | 499870 | B5DF04 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | rad51 | 406487 | Q5TYR1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0005524 | ATP binding |
| GO:0008094 | DNA-dependent ATPase activity |
| GO:0003690 | double-stranded DNA binding |
| GO:0000150 | recombinase activity |
| GO:0003697 | single-stranded DNA binding |
| GO:0000724 | double-strand break repair via homologous recombination |
| GO:1990426 | mitotic recombination-dependent replication fork processing |
| InterPro ID | InterPro Term |
|---|---|
| IPR003593 | AAA+_ATPase |
| IPR011941 | DNA_recomb/repair_Rad51 |
| IPR013632 | DNA_recomb/repair_Rad51_C |
| IPR016467 | DNA_recomb/repair_RecA-like |
| IPR010995 | DNA_repair_Rad51/TF_NusA_a-hlx |
| IPR027417 | P-loop_NTPase |
| IPR033925 | Rad51_DMC1_RadA |
| IPR020588 | RecA_ATP-bd |
| IPR020587 | RecA_monomer-monomer_interface |
| Pfam ID | Pfam Term |
|---|---|
| PF08423 | Rad51 |