| Tag | Content |
|---|---|
| Uniprot ID | Q5TYR1 |
| Entrez ID | 406487 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_213206.2 |
| Ensembl protein ID | ENSDARP00000060705; ENSDARP00000152302; |
| Ensembl nucleotide ID | ENSDARG00000111948; ENSDARG00000041411; |
| Gene name | DNA repair protein RAD51 homolog |
| Gene symbol | rad51 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. |
| Sequence | MAMRNASRVE VEAEVEEEEN FGPQPVSRLE QSGISSSDIK KLEDGGFHTV EAVAYAPKKE 60 LLNIKGISEA KADKILTEAA KMVPMGFTTA TEFHQRRAEI IQISTGSKEL DKLLQGGIET 120 GSITEMFGEF RTGKTQLCHT LAVTCQLPID QGGGEGKAMY IDTEGTFRPE RLLAVAERYG 180 LVGSDVLDNV AYARAFNTDH QTQLLYQASA MMTESRYALL IVDSATALYR TDYSGRGELS 240 ARQGHLGRFL RMLLRLADEF GVAVVITNQV VAQVDGAAMF SADPKKPIGG NILAHASTTR 300 LYLRKGRGET RICKIYDSPC LPEAEAMFAI NADGVGDAKD |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RAD51 | 514749 | Q2KJ94 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 403568 | Q8MKI8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 102177525 | A0A452G921 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 5888 | Q06609 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Rad51 | 19361 | Q08297 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 453339 | A0A2I3SZ08 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 100141309 | B0M1M6 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 100008661 | G1TCL3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Rad51 | 499870 | B5DF04 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | rad51 | 406487 | Q5TYR1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0000794 | condensed nuclear chromosome |
| GO:0005524 | ATP binding |
| GO:0008094 | DNA-dependent ATPase activity |
| GO:0003690 | double-stranded DNA binding |
| GO:0000150 | recombinase activity |
| GO:0003697 | single-stranded DNA binding |
| GO:0070192 | chromosome organization involved in meiotic cell cycle |
| GO:0000730 | DNA recombinase assembly |
| GO:0000724 | double-strand break repair via homologous recombination |
| GO:0071425 | hematopoietic stem cell proliferation |
| GO:0006312 | mitotic recombination |
| GO:1990426 | mitotic recombination-dependent replication fork processing |
| GO:0007131 | reciprocal meiotic recombination |
| GO:0046686 | response to cadmium ion |
| GO:0051597 | response to methylmercury |
| GO:0042148 | strand invasion |
| InterPro ID | InterPro Term |
|---|---|
| IPR003593 | AAA+_ATPase |
| IPR011941 | DNA_recomb/repair_Rad51 |
| IPR013632 | DNA_recomb/repair_Rad51_C |
| IPR016467 | DNA_recomb/repair_RecA-like |
| IPR010995 | DNA_repair_Rad51/TF_NusA_a-hlx |
| IPR027417 | P-loop_NTPase |
| IPR033925 | Rad51_DMC1_RadA |
| IPR020588 | RecA_ATP-bd |
| IPR020587 | RecA_monomer-monomer_interface |
| Pfam ID | Pfam Term |
|---|---|
| PF08423 | Rad51 |