| Tag | Content |
|---|---|
| Uniprot ID | Q08297; Q3UAY5; |
| Entrez ID | 19361 |
| Genbank protein ID | BAA02961.1; BAA02718.1; BAC36357.1; AAH27384.1; BAE30162.1; BAE30179.1; BAB27489.1; |
| Genbank nucleotide ID | NM_011234.4 |
| Ensembl protein ID | ENSMUSP00000028795 |
| Ensembl nucleotide ID | ENSMUSG00000027323 |
| Gene name | DNA repair protein RAD51 homolog 1 |
| Gene symbol | Rad51 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:15834424). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (By similarity). |
| Sequence | MAMQMQLEAS ADTSVEEESF GPQPISRLEQ CGINANDVKK LEEAGYHTVE AVAYAPKKEL 60 INIKGISEAK ADKILTEAAK LVPMGFTTAT EFHQRRSEII QITTGSKELD KLLQGGIETG 120 SITEMFGEFR TGKTQICHTL AVTCQLPIDR GGGEGKAMYI DTEGTFRPER LLAVAERYGL 180 SGSDVLDNVA YARGFNTDHQ TQLLYQASAM MVESRYALLI VDSATALYRT DYSGRGELSA 240 RQMHLARFLR MLLRLADEFG VAVVITNQVV AQVDGAAMFA ADPKKPIGGN IIAHASTTRL 300 YLRKGRGETR ICKIYDSPCL PEAEAMFAIN ADGVGDAKD 339 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RAD51 | 514749 | Q2KJ94 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 403568 | Q8MKI8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 102177525 | A0A452G921 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 5888 | Q06609 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Rad51 | 19361 | Q08297 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 453339 | A0A2I3SZ08 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 100141309 | B0M1M6 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 100008661 | G1TCL3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Rad51 | 499870 | B5DF04 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | rad51 | 406487 | Q5TYR1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000150 | recombinase activity | IBA |
| GO:0003682 | chromatin binding | ISO |
| GO:0003682 | chromatin binding | IDA |
| GO:0003690 | double-stranded DNA binding | ISS |
| GO:0003690 | double-stranded DNA binding | ISO |
| GO:0003690 | double-stranded DNA binding | IBA |
| GO:0003697 | single-stranded DNA binding | ISO |
| GO:0003697 | single-stranded DNA binding | IBA |
| GO:0003697 | single-stranded DNA binding | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | ISO |
| GO:0008022 | protein C-terminus binding | ISO |
| GO:0008094 | DNA-dependent ATPase activity | IBA |
| GO:0017116 | single-stranded DNA helicase activity | ISS |
| GO:0017116 | single-stranded DNA helicase activity | ISO |
| GO:0019899 | enzyme binding | ISO |
| GO:0042802 | identical protein binding | ISO |
| GO:0070182 | DNA polymerase binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000722 | telomere maintenance via recombination | IGI |
| GO:0000724 | double-strand break repair via homologous recombination | ISO |
| GO:0000724 | double-strand break repair via homologous recombination | IDA |
| GO:0000724 | double-strand break repair via homologous recombination | IMP |
| GO:0000730 | DNA recombinase assembly | ISS |
| GO:0000730 | DNA recombinase assembly | ISO |
| GO:0000730 | DNA recombinase assembly | IBA |
| GO:0001932 | regulation of protein phosphorylation | IMP |
| GO:0006268 | DNA unwinding involved in DNA replication | ISS |
| GO:0006268 | DNA unwinding involved in DNA replication | ISO |
| GO:0006281 | DNA repair | TAS |
| GO:0006312 | mitotic recombination | IBA |
| GO:0006974 | cellular response to DNA damage stimulus | ISS |
| GO:0006974 | cellular response to DNA damage stimulus | ISO |
| GO:0006974 | cellular response to DNA damage stimulus | TAS |
| GO:0007131 | reciprocal meiotic recombination | IBA |
| GO:0007131 | reciprocal meiotic recombination | TAS |
| GO:0010165 | response to X-ray | IEA |
| GO:0010212 | response to ionizing radiation | IBA |
| GO:0010569 | regulation of double-strand break repair via homologous recombination | ISS |
| GO:0010569 | regulation of double-strand break repair via homologous recombination | ISO |
| GO:0010833 | telomere maintenance via telomere lengthening | IGI |
| GO:0031297 | replication fork processing | ISO |
| GO:0031297 | replication fork processing | IMP |
| GO:0032200 | telomere organization | IMP |
| GO:0036297 | interstrand cross-link repair | ISS |
| GO:0036297 | interstrand cross-link repair | ISO |
| GO:0042148 | strand invasion | IBA |
| GO:0051106 | positive regulation of DNA ligation | ISO |
| GO:0051260 | protein homooligomerization | ISO |
| GO:0051321 | meiotic cell cycle | IDA |
| GO:0070192 | chromosome organization involved in meiotic cell cycle | IBA |
| GO:0070192 | chromosome organization involved in meiotic cell cycle | IMP |
| GO:0071312 | cellular response to alkaloid | IMP |
| GO:0071479 | cellular response to ionizing radiation | ISS |
| GO:0071479 | cellular response to ionizing radiation | ISO |
| GO:0071480 | cellular response to gamma radiation | IEA |
| GO:0072711 | cellular response to hydroxyurea | IMP |
| GO:0072719 | cellular response to cisplatin | IEA |
| GO:0072757 | cellular response to camptothecin | ISS |
| GO:0072757 | cellular response to camptothecin | ISO |
| GO:1904631 | response to glucoside | IEA |
| GO:1990414 | replication-born double-strand break repair via sister chromatid exchange | IMP |
| GO:1990426 | mitotic recombination-dependent replication fork processing | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000228 | nuclear chromosome | ISS |
| GO:0000228 | nuclear chromosome | ISO |
| GO:0000784 | nuclear chromosome, telomeric region | ISO |
| GO:0000784 | nuclear chromosome, telomeric region | IDA |
| GO:0000785 | chromatin | ISO |
| GO:0000790 | nuclear chromatin | ISO |
| GO:0000793 | condensed chromosome | IDA |
| GO:0000794 | condensed nuclear chromosome | IDA |
| GO:0000794 | condensed nuclear chromosome | IBA |
| GO:0000795 | synaptonemal complex | TAS |
| GO:0000800 | lateral element | IDA |
| GO:0000800 | lateral element | ISO |
| GO:0005634 | nucleus | ISS |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005737 | cytoplasm | ISS |
| GO:0005737 | cytoplasm | ISO |
| GO:0005739 | mitochondrion | ISO |
| GO:0005759 | mitochondrial matrix | IEA |
| GO:0005815 | microtubule organizing center | IEA |
| GO:0016605 | PML body | ISO |
| GO:0032991 | protein-containing complex | ISO |
| GO:0035861 | site of double-strand break | ISO |
| GO:0048471 | perinuclear region of cytoplasm | ISS |
| GO:0048471 | perinuclear region of cytoplasm | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-5685938 | HDR through Single Strand Annealing (SSA) | IEA |
| R-MMU-5685942 | HDR through Homologous Recombination (HRR) | IEA |
| R-MMU-5693532 | DNA Double-Strand Break Repair | IEA |
| R-MMU-5693537 | Resolution of D-Loop Structures | IEA |
| R-MMU-5693538 | Homology Directed Repair | IEA |
| R-MMU-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | IEA |
| R-MMU-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | IEA |
| R-MMU-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates | IEA |
| R-MMU-5693579 | Homologous DNA Pairing and Strand Exchange | IEA |
| R-MMU-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange | IEA |
| R-MMU-73894 | DNA Repair | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0007 | Acetylation |
| KW-0067 | ATP-binding |
| KW-0158 | Chromosome |
| KW-0963 | Cytoplasm |
| KW-0206 | Cytoskeleton |
| KW-0227 | DNA damage |
| KW-0233 | DNA recombination |
| KW-0234 | DNA repair |
| KW-0238 | DNA-binding |
| KW-1017 | Isopeptide bond |
| KW-0496 | Mitochondrion |
| KW-0547 | Nucleotide-binding |
| KW-0539 | Nucleus |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0832 | Ubl conjugation |
| InterPro ID | InterPro Term |
|---|---|
| IPR003593 | AAA+_ATPase |
| IPR011941 | DNA_recomb/repair_Rad51 |
| IPR013632 | DNA_recomb/repair_Rad51_C |
| IPR016467 | DNA_recomb/repair_RecA-like |
| IPR010995 | DNA_repair_Rad51/TF_NusA_a-hlx |
| IPR027417 | P-loop_NTPase |
| IPR033925 | Rad51_DMC1_RadA |
| IPR020588 | RecA_ATP-bd |
| IPR020587 | RecA_monomer-monomer_interface |
| Pfam ID | Pfam Term |
|---|---|
| PF08423 | Rad51 |