Gene: RAD51

Basic information

Tag Content
Uniprot ID B0M1M6
Entrez ID 100141309
Genbank protein ID ABZ89107.1; BAG09486.1;
Genbank nucleotide ID NM_001123181.1
Ensembl protein ID ENSSSCP00000005138
Ensembl nucleotide ID ENSSSCG00000004766
Gene name DNA repair protein RAD51 homolog
Gene symbol RAD51
Organism Sus scrofa
NCBI taxa ID 9823
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange.
Sequence
MAVQMQLESN ADTSVEEESF GPQPISRLEQ CGINANDVKK LEEAGFHTVE AVAYAPKKEL 60
INIKGISEAK ADKILTEAAK LVPMGFTTAT EFHQRRSEII QITTGSKELD KLLQGGIETG 120
SITEMFGEFR TGKTQICHTL AVTCQLPIDR GGGEGKAMYI DTEGTFRPER LLAVAERYGL 180
SGSDVLDNVA YARAFNTDHQ TQLLYQASAM MVESRYALLI IDSATALYRT DYSGRGELSA 240
RQMHLARFLR MLLRLADEFG VAVVITNQVV AQVDGAAMFA ADPKKPIGGN IIAHASTTRL 300
YLRKGRGETR ICKIYDSPCL PEAEAMFAIN ADGVGDAKD 339

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologRAD51514749Q2KJ94Bos taurusPredictionMore>>
1:1 orthologRAD51403568Q8MKI8Canis lupus familiarisPredictionMore>>
1:1 orthologRAD51102177525A0A452G921Capra hircusPredictionMore>>
1:1 orthologRAD515888Q06609Homo sapiensPublicationMore>>
1:1 orthologRad5119361Q08297Mus musculusPredictionMore>>
1:1 orthologRAD51453339A0A2I3SZ08Pan troglodytesPredictionMore>>
1:1 orthologRAD51100141309B0M1M6Sus scrofaPredictionMore>>
1:1 orthologRAD51100008661G1TCL3Oryctolagus cuniculusPredictionMore>>
1:1 orthologRad51499870B5DF04Rattus norvegicusPredictionMore>>
1:1 ortholograd51406487Q5TYR1Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0000794 condensed nuclear chromosome
GO:0000800 lateral element
GO:0005739 mitochondrion
GO:0000790 nuclear chromatin
GO:0000784 nuclear chromosome, telomeric region
GO:0048471 perinuclear region of cytoplasm
GO:0016605 PML body
GO:0032991 protein-containing complex
GO:0035861 site of double-strand break
GO:0005524 ATP binding
GO:0003682 chromatin binding
GO:0070182 DNA polymerase binding
GO:0008094 DNA-dependent ATPase activity
GO:0003690 double-stranded DNA binding
GO:0042802 identical protein binding
GO:0008022 protein C-terminus binding
GO:0000150 recombinase activity
GO:0003697 single-stranded DNA binding
GO:0017116 single-stranded DNA helicase activity
GO:0072757 cellular response to camptothecin
GO:0072711 cellular response to hydroxyurea
GO:0071479 cellular response to ionizing radiation
GO:0070192 chromosome organization involved in meiotic cell cycle
GO:0000730 DNA recombinase assembly
GO:0006268 DNA unwinding involved in DNA replication
GO:0036297 interstrand cross-link repair
GO:0006312 mitotic recombination
GO:1990426 mitotic recombination-dependent replication fork processing
GO:0051106 positive regulation of DNA ligation
GO:0007131 reciprocal meiotic recombination
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0001932 regulation of protein phosphorylation
GO:1990414 replication-born double-strand break repair via sister chromatid exchange
GO:0010212 response to ionizing radiation
GO:0042148 strand invasion
GO:0000722 telomere maintenance via recombination
GO:0010833 telomere maintenance via telomere lengthening

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0067 ATP-binding
KW-0227 DNA damage
KW-0233 DNA recombination
KW-0234 DNA repair
KW-0238 DNA-binding
KW-0547 Nucleotide-binding
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR003593 AAA+_ATPase
IPR011941 DNA_recomb/repair_Rad51
IPR013632 DNA_recomb/repair_Rad51_C
IPR016467 DNA_recomb/repair_RecA-like
IPR010995 DNA_repair_Rad51/TF_NusA_a-hlx
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd
IPR020587 RecA_monomer-monomer_interface

PROSITE

PROSITE ID PROSITE Term
PS50162 RECA_2
PS50163 RECA_3

Pfam

Pfam ID Pfam Term
PF08423 Rad51