Gene: RAD51

Basic information

Tag Content
Uniprot ID Q8MKI8
Entrez ID 403568
Genbank protein ID BAB91246.1
Genbank nucleotide ID NM_001003043.1; XM_005638169.2;
Ensembl protein ID ENSCAFP00030037898; ENSCAFP00040041838;
Ensembl nucleotide ID ENSCAFG00030023614; ENSCAFG00040025670;
Gene name DNA repair protein RAD51 homolog 1
Gene symbol RAD51
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair.
Sequence
MAMQMQLEAN ADTSVEEESF GPQPISRLEQ CGINANDVKK LEEAGFHTVE AVAYAPKKEL 60
ISIKGISEAK ADKILTEAAK LVPMGFTTAT EFHQRRSEII QITTGSKELD KLLQGGIETG 120
SITEMFGEFR TGKTQICHTL AVTCQLPIDR GGGEGKAMYI DTEGTFRPER LLAVAERYGL 180
SGSDVLDNVA YARGFNTDHQ TQLLYQASAM MVESRYALLI VDSATALYRT DYSGRGELSA 240
RQMHLARFLR MLLRLADEFG VAVVITNQVV AQVDGAAMFA ADPKKPIGGN IIAHASTTRL 300
YLRKGRGETR ICKIYDSPCL PEAEAMFAIN ADGVGDAKD 339

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologRAD51514749Q2KJ94Bos taurusPredictionMore>>
1:1 orthologRAD51403568Q8MKI8Canis lupus familiarisPredictionMore>>
1:1 orthologRAD51102177525A0A452G921Capra hircusPredictionMore>>
1:1 orthologRAD515888Q06609Homo sapiensPublicationMore>>
1:1 orthologRad5119361Q08297Mus musculusPredictionMore>>
1:1 orthologRAD51453339A0A2I3SZ08Pan troglodytesPredictionMore>>
1:1 orthologRAD51100141309B0M1M6Sus scrofaPredictionMore>>
1:1 orthologRAD51100008661G1TCL3Oryctolagus cuniculusPredictionMore>>
1:1 orthologRad51499870B5DF04Rattus norvegicusPredictionMore>>
1:1 ortholograd51406487Q5TYR1Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0005737 cytoplasm
GO:0000800 lateral element
GO:0005815 microtubule organizing center
GO:0005759 mitochondrial matrix
GO:0000790 nuclear chromatin
GO:0000228 nuclear chromosome
GO:0000784 nuclear chromosome, telomeric region
GO:0005634 nucleus
GO:0048471 perinuclear region of cytoplasm
GO:0016605 PML body
GO:0032991 protein-containing complex
GO:0035861 site of double-strand break
GO:0005524 ATP binding
GO:0003682 chromatin binding
GO:0070182 DNA polymerase binding
GO:0008094 DNA-dependent ATPase activity
GO:0003690 double-stranded DNA binding
GO:0042802 identical protein binding
GO:0008022 protein C-terminus binding
GO:0000150 recombinase activity
GO:0003697 single-stranded DNA binding
GO:0017116 single-stranded DNA helicase activity
GO:0072757 cellular response to camptothecin
GO:0006974 cellular response to DNA damage stimulus
GO:0072711 cellular response to hydroxyurea
GO:0071479 cellular response to ionizing radiation
GO:0070192 chromosome organization involved in meiotic cell cycle
GO:0000730 DNA recombinase assembly
GO:0006268 DNA unwinding involved in DNA replication
GO:0000724 double-strand break repair via homologous recombination
GO:0036297 interstrand cross-link repair
GO:0051321 meiotic cell cycle
GO:0006312 mitotic recombination
GO:1990426 mitotic recombination-dependent replication fork processing
GO:0051106 positive regulation of DNA ligation
GO:0007131 reciprocal meiotic recombination
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0001932 regulation of protein phosphorylation
GO:1990414 replication-born double-strand break repair via sister chromatid exchange
GO:0010212 response to ionizing radiation
GO:0042148 strand invasion
GO:0000722 telomere maintenance via recombination
GO:0010833 telomere maintenance via telomere lengthening

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0067 ATP-binding
KW-0158 Chromosome
KW-0963 Cytoplasm
KW-0206 Cytoskeleton
KW-0227 DNA damage
KW-0233 DNA recombination
KW-0234 DNA repair
KW-0238 DNA-binding
KW-1017 Isopeptide bond
KW-0496 Mitochondrion
KW-0547 Nucleotide-binding
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0832 Ubl conjugation

Interpro

InterPro ID InterPro Term
IPR003593 AAA+_ATPase
IPR011941 DNA_recomb/repair_Rad51
IPR013632 DNA_recomb/repair_Rad51_C
IPR016467 DNA_recomb/repair_RecA-like
IPR010995 DNA_repair_Rad51/TF_NusA_a-hlx
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd
IPR020587 RecA_monomer-monomer_interface

PROSITE

PROSITE ID PROSITE Term
PS50162 RECA_2
PS50163 RECA_3

Pfam

Pfam ID Pfam Term
PF08423 Rad51