| Tag | Content |
|---|---|
| Uniprot ID | Q8MKI8 |
| Entrez ID | 403568 |
| Genbank protein ID | BAB91246.1 |
| Genbank nucleotide ID | NM_001003043.1; XM_005638169.2; |
| Ensembl protein ID | ENSCAFP00030037898; ENSCAFP00040041838; |
| Ensembl nucleotide ID | ENSCAFG00030023614; ENSCAFG00040025670; |
| Gene name | DNA repair protein RAD51 homolog 1 |
| Gene symbol | RAD51 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair. |
| Sequence | MAMQMQLEAN ADTSVEEESF GPQPISRLEQ CGINANDVKK LEEAGFHTVE AVAYAPKKEL 60 ISIKGISEAK ADKILTEAAK LVPMGFTTAT EFHQRRSEII QITTGSKELD KLLQGGIETG 120 SITEMFGEFR TGKTQICHTL AVTCQLPIDR GGGEGKAMYI DTEGTFRPER LLAVAERYGL 180 SGSDVLDNVA YARGFNTDHQ TQLLYQASAM MVESRYALLI VDSATALYRT DYSGRGELSA 240 RQMHLARFLR MLLRLADEFG VAVVITNQVV AQVDGAAMFA ADPKKPIGGN IIAHASTTRL 300 YLRKGRGETR ICKIYDSPCL PEAEAMFAIN ADGVGDAKD 339 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RAD51 | 514749 | Q2KJ94 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 403568 | Q8MKI8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 102177525 | A0A452G921 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 5888 | Q06609 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Rad51 | 19361 | Q08297 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 453339 | A0A2I3SZ08 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 100141309 | B0M1M6 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | RAD51 | 100008661 | G1TCL3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Rad51 | 499870 | B5DF04 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | rad51 | 406487 | Q5TYR1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0000793 | condensed chromosome |
| GO:0000794 | condensed nuclear chromosome |
| GO:0005737 | cytoplasm |
| GO:0000800 | lateral element |
| GO:0005815 | microtubule organizing center |
| GO:0005759 | mitochondrial matrix |
| GO:0000790 | nuclear chromatin |
| GO:0000228 | nuclear chromosome |
| GO:0000784 | nuclear chromosome, telomeric region |
| GO:0005634 | nucleus |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0016605 | PML body |
| GO:0032991 | protein-containing complex |
| GO:0035861 | site of double-strand break |
| GO:0005524 | ATP binding |
| GO:0003682 | chromatin binding |
| GO:0070182 | DNA polymerase binding |
| GO:0008094 | DNA-dependent ATPase activity |
| GO:0003690 | double-stranded DNA binding |
| GO:0042802 | identical protein binding |
| GO:0008022 | protein C-terminus binding |
| GO:0000150 | recombinase activity |
| GO:0003697 | single-stranded DNA binding |
| GO:0017116 | single-stranded DNA helicase activity |
| GO:0072757 | cellular response to camptothecin |
| GO:0006974 | cellular response to DNA damage stimulus |
| GO:0072711 | cellular response to hydroxyurea |
| GO:0071479 | cellular response to ionizing radiation |
| GO:0070192 | chromosome organization involved in meiotic cell cycle |
| GO:0000730 | DNA recombinase assembly |
| GO:0006268 | DNA unwinding involved in DNA replication |
| GO:0000724 | double-strand break repair via homologous recombination |
| GO:0036297 | interstrand cross-link repair |
| GO:0051321 | meiotic cell cycle |
| GO:0006312 | mitotic recombination |
| GO:1990426 | mitotic recombination-dependent replication fork processing |
| GO:0051106 | positive regulation of DNA ligation |
| GO:0007131 | reciprocal meiotic recombination |
| GO:0010569 | regulation of double-strand break repair via homologous recombination |
| GO:0001932 | regulation of protein phosphorylation |
| GO:1990414 | replication-born double-strand break repair via sister chromatid exchange |
| GO:0010212 | response to ionizing radiation |
| GO:0042148 | strand invasion |
| GO:0000722 | telomere maintenance via recombination |
| GO:0010833 | telomere maintenance via telomere lengthening |
| Keyword ID | Keyword Term |
|---|---|
| KW-0007 | Acetylation |
| KW-0067 | ATP-binding |
| KW-0158 | Chromosome |
| KW-0963 | Cytoplasm |
| KW-0206 | Cytoskeleton |
| KW-0227 | DNA damage |
| KW-0233 | DNA recombination |
| KW-0234 | DNA repair |
| KW-0238 | DNA-binding |
| KW-1017 | Isopeptide bond |
| KW-0496 | Mitochondrion |
| KW-0547 | Nucleotide-binding |
| KW-0539 | Nucleus |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0832 | Ubl conjugation |
| InterPro ID | InterPro Term |
|---|---|
| IPR003593 | AAA+_ATPase |
| IPR011941 | DNA_recomb/repair_Rad51 |
| IPR013632 | DNA_recomb/repair_Rad51_C |
| IPR016467 | DNA_recomb/repair_RecA-like |
| IPR010995 | DNA_repair_Rad51/TF_NusA_a-hlx |
| IPR027417 | P-loop_NTPase |
| IPR033925 | Rad51_DMC1_RadA |
| IPR020588 | RecA_ATP-bd |
| IPR020587 | RecA_monomer-monomer_interface |
| Pfam ID | Pfam Term |
|---|---|
| PF08423 | Rad51 |