| Tag | Content |
|---|---|
| Uniprot ID | A0A452DMZ7 |
| Entrez ID | 102189962 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005686141.3 |
| Ensembl protein ID | ENSCHIP00000001127 |
| Ensembl nucleotide ID | ENSCHIG00000001922 |
| Gene name | Transforming growth factor beta |
| Gene symbol | TGFB3 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MHLLAKPQSS GSREAAWFSS LLLHGCRGLL LPGLVAFLPG PCLKMHLQRA LVVLALLNFA 60 TVSLSMSTCT TLDFNHIKRK RVEAIRGQIL SKLRLTSPPD PSGLASIPIQ VLDLYNSTRE 120 LLEEVHGERG DVCTQANTES EYYAKEIYKF DMIQGLEEHN DLTVCPKGIT SKIFRFNVSS 180 VEKNETNLFR AEFRVFRMPN PASKRSEQRI ELFQILQPGE HIAKQRYIDG KNLPTRGTGE 240 WLSFDVTDTV REWLLRRESN LGLEISIHCP CHTFQPNGDI LENIQELMEI KFKGVDSDDD 300 PGRGDLGRLK KKKEHIPHLI LMMIPPNRLD SPGHSQRKKR ALDTNYCFRN LEENCCVRPL 360 YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSSDTTHST VLGLYNTLNP EASASPCCVP 420 QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS 452 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TGFB3 | 538957 | A6QP91 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TGFB3 | 490796 | F1PR85 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | TGFB3 | 102189962 | A0A452DMZ7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TGFB3 | 7043 | P10600 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Tgfb3 | P17125 | CPO | E11.5, E12.5, E14.0, E13.5, E14.5, E15.5 | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TGFB3 | 453054 | H2Q8N5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TGFB3 | 397400 | K7GSJ9 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Tgfb3 | 25717 | Q07258 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tgfb3 | 369195 | Q66I23 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0062023 | collagen-containing extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0016021 | integral component of membrane |
| GO:0043231 | intracellular membrane-bounded organelle |
| GO:0008083 | growth factor activity |
| GO:0042802 | identical protein binding |
| GO:0050431 | transforming growth factor beta binding |
| GO:0034713 | type I transforming growth factor beta receptor binding |
| GO:0005114 | type II transforming growth factor beta receptor binding |
| GO:0034714 | type III transforming growth factor beta receptor binding |
| GO:0045216 | cell-cell junction organization |
| GO:0070483 | detection of hypoxia |
| GO:0060325 | face morphogenesis |
| GO:0010936 | negative regulation of macrophage cytokine production |
| GO:1904706 | negative regulation of vascular smooth muscle cell proliferation |
| GO:0043932 | ossification involved in bone remodeling |
| GO:0030501 | positive regulation of bone mineralization |
| GO:0051781 | positive regulation of cell division |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0032967 | positive regulation of collagen biosynthetic process |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:0050714 | positive regulation of protein secretion |
| GO:0051496 | positive regulation of stress fiber assembly |
| GO:1905075 | positive regulation of tight junction disassembly |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0032570 | response to progesterone |
| GO:0007435 | salivary gland morphogenesis |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |