| Tag | Content |
|---|---|
| Uniprot ID | F1PR85 |
| Entrez ID | 490796 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_849026.4 |
| Ensembl protein ID | ENSCAFP00000025188 |
| Ensembl nucleotide ID | ENSCAFG00000017101 |
| Gene name | Transforming growth factor beta 3 |
| Gene symbol | TGFB3 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MHLLAKPQSS GSREAARFSS LLLHDCWGLL LARPCSPPAS LPSLRMKMHL QRALVVLALL 60 NFATVSLSLS TCTTLDFGHI KKKRVEAIRG QILSKLRLTS PPEPSVMTHV PYQVLALYNS 120 TRELLEEMQG EREDSCTQEN TESEYYAKEI HKFDMIQGLA EHNELAVCPK GITSKVFRFN 180 VSSVEKNGTN LFRAEFRVLR VPNPSSKRSE QRIELFQILR PDEHIAKQRY IGGKNLPTRG 240 TAEWLSFDVT DTVREWLLRR ESNLGLEISI HCPCHTFQPN GDILENIHEV MEIKFKGVDS 300 EEDHGRGDLG RLKKQKDHHN PHLILMMIPP HRLDNPGQGG QRKKRALDTN YCFRNLEENC 360 CVRPLYIDFR QDLGWKWVHE PKGYYANFCS GPCPYLRSAD TTHSTVLGLY NTLNPEASAS 420 PCCVPQDLEP LTILYYVGRT PKVEQLSNMV VKSCKCS 457 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TGFB3 | 538957 | A6QP91 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TGFB3 | 490796 | F1PR85 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | TGFB3 | 102189962 | A0A452DMZ7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TGFB3 | 7043 | P10600 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Tgfb3 | P17125 | CPO | E11.5, E12.5, E14.0, E13.5, E14.5, E15.5 | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TGFB3 | 453054 | H2Q8N5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TGFB3 | 397400 | K7GSJ9 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Tgfb3 | 25717 | Q07258 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tgfb3 | 369195 | Q66I23 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0062023 | collagen-containing extracellular matrix |
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0016021 | integral component of membrane |
| GO:0043231 | intracellular membrane-bounded organelle |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0042802 | identical protein binding |
| GO:0050431 | transforming growth factor beta binding |
| GO:0034713 | type I transforming growth factor beta receptor binding |
| GO:0005114 | type II transforming growth factor beta receptor binding |
| GO:0034714 | type III transforming growth factor beta receptor binding |
| GO:0030509 | BMP signaling pathway |
| GO:0045216 | cell-cell junction organization |
| GO:0070483 | detection of hypoxia |
| GO:0060325 | face morphogenesis |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0010936 | negative regulation of macrophage cytokine production |
| GO:1904706 | negative regulation of vascular smooth muscle cell proliferation |
| GO:0043932 | ossification involved in bone remodeling |
| GO:0030501 | positive regulation of bone mineralization |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0032967 | positive regulation of collagen biosynthetic process |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0050714 | positive regulation of protein secretion |
| GO:0051496 | positive regulation of stress fiber assembly |
| GO:1905075 | positive regulation of tight junction disassembly |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0042127 | regulation of cell population proliferation |
| GO:0001666 | response to hypoxia |
| GO:0032570 | response to progesterone |
| GO:0007435 | salivary gland morphogenesis |
| GO:0060395 | SMAD protein signal transduction |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |