| Tag | Content |
|---|---|
| Uniprot ID | Q07258; Q56A31; |
| Entrez ID | 25717 |
| Genbank protein ID | AAA67915.1; AAH92195.1; CAA50722.1; |
| Genbank nucleotide ID | NM_013174.2 |
| Ensembl protein ID | ENSRNOP00000013516 |
| Ensembl nucleotide ID | ENSRNOG00000009867 |
| Gene name | Transforming growth factor beta-3 proprotein |
| Gene symbol | Tgfb3 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. |
| Sequence | MKMHLQRALV VLALLNLATV SLSLSTCTTL DFGHIKKKRV EAIRGQILSK LRLTSPPEPS 60 VMTHVPYQVL ALYNSTRELL EEMHGEREEG CTQETSESEY YAKEIHKFDM IQGLAEHNEL 120 AVCPKGITSK VFRFNVSSVE KNGTNLFRAE FRVLRVPNPS SKRTEQRIEL FQILRPDEHI 180 AKQRYIGGKN LPTRGTAEWL SFDVTDTVRE WLLRRESNLG LEISIHCPCH TFQPNGDILE 240 NVHEVMEIKF KGVDNEDDHG RGDLGRLKKQ KDHHNPHLIL MMIPPHRLDS PGQGGQRKKR 300 ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSSDTTHST 360 VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS 412 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TGFB3 | 538957 | A6QP91 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TGFB3 | 490796 | F1PR85 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | TGFB3 | 102189962 | A0A452DMZ7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TGFB3 | 7043 | P10600 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Tgfb3 | P17125 | CPO | E11.5, E12.5, E14.0, E13.5, E14.5, E15.5 | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TGFB3 | 453054 | H2Q8N5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TGFB3 | 397400 | K7GSJ9 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Tgfb3 | 25717 | Q07258 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tgfb3 | 369195 | Q66I23 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0062023 | collagen-containing extracellular matrix |
| GO:0005737 | cytoplasm |
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0043025 | neuronal cell body |
| GO:0005634 | nucleus |
| GO:0030141 | secretory granule |
| GO:0030315 | T-tubule |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0042802 | identical protein binding |
| GO:0044877 | protein-containing complex binding |
| GO:0050431 | transforming growth factor beta binding |
| GO:0005160 | transforming growth factor beta receptor binding |
| GO:0034713 | type I transforming growth factor beta receptor binding |
| GO:0005114 | type II transforming growth factor beta receptor binding |
| GO:0034714 | type III transforming growth factor beta receptor binding |
| GO:0000187 | activation of MAPK activity |
| GO:0007568 | aging |
| GO:0009887 | animal organ morphogenesis |
| GO:0030509 | BMP signaling pathway |
| GO:0045216 | cell-cell junction organization |
| GO:0071363 | cellular response to growth factor stimulus |
| GO:0070483 | detection of hypoxia |
| GO:0048565 | digestive tract development |
| GO:0048702 | embryonic neurocranium morphogenesis |
| GO:0060325 | face morphogenesis |
| GO:0007565 | female pregnancy |
| GO:0060364 | frontal suture morphogenesis |
| GO:0001701 | in utero embryonic development |
| GO:0048839 | inner ear development |
| GO:0048286 | lung alveolus development |
| GO:0030324 | lung development |
| GO:0030879 | mammary gland development |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0010936 | negative regulation of macrophage cytokine production |
| GO:0043524 | negative regulation of neuron apoptotic process |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO:1904706 | negative regulation of vascular smooth muscle cell proliferation |
| GO:0043932 | ossification involved in bone remodeling |
| GO:0043065 | positive regulation of apoptotic process |
| GO:0030501 | positive regulation of bone mineralization |
| GO:0051781 | positive regulation of cell division |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0032967 | positive regulation of collagen biosynthetic process |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:0051491 | positive regulation of filopodium assembly |
| GO:0010628 | positive regulation of gene expression |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0050714 | positive regulation of protein secretion |
| GO:0060391 | positive regulation of SMAD protein signal transduction |
| GO:0051496 | positive regulation of stress fiber assembly |
| GO:1905075 | positive regulation of tight junction disassembly |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0042127 | regulation of cell population proliferation |
| GO:0045601 | regulation of endothelial cell differentiation |
| GO:0030856 | regulation of epithelial cell differentiation |
| GO:0050678 | regulation of epithelial cell proliferation |
| GO:0043627 | response to estrogen |
| GO:0001666 | response to hypoxia |
| GO:0034616 | response to laminar fluid shear stress |
| GO:0032570 | response to progesterone |
| GO:0007435 | salivary gland morphogenesis |
| GO:0062009 | secondary palate development |
| GO:0060395 | SMAD protein signal transduction |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| GO:0042060 | wound healing |