| Tag | Content |
|---|---|
| Uniprot ID | Q66I23 |
| Entrez ID | 369195 |
| Genbank protein ID | AAH81579.1; AAU14139.1; AAW66727.1; |
| Genbank nucleotide ID | NM_194386.2 |
| Ensembl protein ID | ENSDARP00000025519 |
| Ensembl nucleotide ID | ENSDARG00000019367 |
| Gene name | Transforming growth factor beta |
| Gene symbol | tgfb3 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. |
| Sequence | MHLGKGLLFV LLLNSVTMSL SLSTCTTVDI DNIKKKRVEA IRGQILSKLR LTSPPQTLGP 60 SQVPYQVLAL YNSTRDLLDG FGKDRHQSCG QDNTETEYYA KEIHKFNMIQ GSPENNDLPY 120 CPKGITSKVF RFDVSIMEKN ASNLFRAEFR ALRMPNLSTS RTEQRIELYQ ILRPDEHIGK 180 QRYIGRKNVM IGGTDEWVSF DVTETVREWL TNRATNLGLE ISVHCPCHTF RPNGEIIENV 240 NEALEVKFRG MDVEDDGPIR SDMGRLKKPK EQNLPHLILM MLPPHRLDVL PTSRRRKRAL 300 DTKYCFSNYE ENCCVRKLYI DFRQDLGWRW IHEPKGYHAN FCSGPCPYLR SADTTHSSLL 360 SLYNTLNPEA SASPCCVPQD LEPLTILYYV GRTPKVEQLS NMIVKSCKCS |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TGFB3 | 538957 | A6QP91 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TGFB3 | 490796 | F1PR85 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | TGFB3 | 102189962 | A0A452DMZ7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TGFB3 | 7043 | P10600 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Tgfb3 | P17125 | CPO | E11.5, E12.5, E14.0, E13.5, E14.5, E15.5 | Mus musculus | Publication | More>> | |
| 1:1 ortholog | TGFB3 | 453054 | H2Q8N5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TGFB3 | 397400 | K7GSJ9 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Tgfb3 | 25717 | Q07258 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tgfb3 | 369195 | Q66I23 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0005114 | type II transforming growth factor beta receptor binding |
| GO:0034714 | type III transforming growth factor beta receptor binding |
| GO:0030509 | BMP signaling pathway |
| GO:0060218 | hematopoietic stem cell differentiation |
| GO:0051781 | positive regulation of cell division |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0061035 | regulation of cartilage development |
| GO:0042127 | regulation of cell population proliferation |
| GO:0030278 | regulation of ossification |
| GO:0060395 | SMAD protein signal transduction |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |