| Tag | Content |
|---|---|
| Uniprot ID | A0A452DVS7 |
| Entrez ID | 102175037 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018057071.1 |
| Ensembl protein ID | ENSCHIP00000003879 |
| Ensembl nucleotide ID | ENSCHIG00000008067 |
| Gene name | Neuropilin |
| Gene symbol | NRP1 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEKGLQLLCA ALALVLGAAG AFRNDKCGDT IKIESPGYLT SPGYPHSYHP SEKCEWLIQA 60 PDPYQRIMIN FNPHFDLEDR DCKYDYVEVI DGENENGRVL GKFCGKIAPS SFVSSGPFLF 120 IKFVSDYETH GAGFSIRYEI FKKGPECSQN YTMPSGVIKS PGFPEKYPNS LECTYIIFAP 180 KMSEIILEFE SFDLEPDSNP PGGVFCRYDR LEIWDGFPDV GPHIGRYCGQ KTPGRILSSS 240 GILSMVFYTD SAIAKEGFSA NYSVLQSSVS EDFKCMEALG MESGEIHSDQ ITASSQYSTN 300 WSAERSRLHY PENGWTPGED SYREWIQVDL GLLRFVTAVG TQGAISKETR RKYYVKTYRI 360 DISSNGEDWI TIKEGNKPVI FQGNTNPTDV VIGVFPKPLI TRFVRIKPVT WETGISMRFE 420 VYGCKITDYP CSGMLGMVSG LISDSQITAS NQGDRNWMPE NIRLVTSRSG WALPPAPHPY 480 VNEWLQVDLA EEKIVRGVII QGGKHRENKV FMRKFKIGYS NNGSDWKMIM DDSKRKAKSF 540 EGNNNYDTPE LRTFPPLSTR FIRIYPERAT HGGLGLRMEL LGCEVEAPTA GPTTPNGNLV 600 DECDDDQANC HSGTGDDFQL TGGTTVLTTE KPTVIDSTIQ SEFPTYGFNC EFGWGSHKTF 660 CHWEHDNHVQ LKWSVLTSKT GPIQDHTGDG NFIYSQADEN QKGKVARLVS PVVYSQNSAH 720 CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ LVWMAIGHQG DHWKEGRVLL HKSLKLYQVI 780 FEGEIGKGNL GGIAVDDISI NNHIPQEDCT KPADLDKKNP ESKIDETGST PGYQGAGEGD 840 ENISRKPGNV LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN 900 FELVDGVKLK KDKLNPQSTY SEA 923 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NRP1 | 102175037 | A0A452DVS7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | NRP1 | 8829 | O14786 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nrp1 | 18186 | P97333 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NRP1 | 450397 | A0A2I3TPR4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Nrp1 | 246331 | Q9QWJ9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | nrp1a | 353246 | Q1RLY9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0030424 | axon |
| GO:0005829 | cytosol |
| GO:0005769 | early endosome |
| GO:0005925 | focal adhesion |
| GO:0098978 | glutamatergic synapse |
| GO:0099055 | integral component of postsynaptic membrane |
| GO:0005883 | neurofilament |
| GO:0097443 | sorting endosome |
| GO:0005096 | GTPase activator activity |
| GO:0046872 | metal ion binding |
| GO:0019901 | protein kinase binding |
| GO:0017154 | semaphorin receptor activity |
| GO:0038085 | vascular endothelial growth factor binding |
| GO:0005021 | vascular endothelial growth factor-activated receptor activity |
| GO:0031532 | actin cytoskeleton reorganization |
| GO:0060978 | angiogenesis involved in coronary vascular morphogenesis |
| GO:0048846 | axon extension involved in axon guidance |
| GO:0007413 | axonal fasciculation |
| GO:0060385 | axonogenesis involved in innervation |
| GO:0150020 | basal dendrite arborization |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0021785 | branchiomotor neuron axon guidance |
| GO:0002042 | cell migration involved in sprouting angiogenesis |
| GO:0035729 | cellular response to hepatocyte growth factor stimulus |
| GO:0071679 | commissural neuron axon guidance |
| GO:0060982 | coronary artery morphogenesis |
| GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching |
| GO:1904835 | dorsal root ganglion morphogenesis |
| GO:0035767 | endothelial cell chemotaxis |
| GO:0021612 | facial nerve structural organization |
| GO:1903375 | facioacoustic ganglion development |
| GO:0021828 | gonadotrophin-releasing hormone neuronal migration to the hypothalamus |
| GO:0048012 | hepatocyte growth factor receptor signaling pathway |
| GO:0007229 | integrin-mediated signaling pathway |
| GO:0097475 | motor neuron migration |
| GO:0048843 | negative regulation of axon extension involved in axon guidance |
| GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| GO:0043524 | negative regulation of neuron apoptotic process |
| GO:1901166 | neural crest cell migration involved in autonomic nervous system development |
| GO:1905040 | otic placode development |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| GO:0050918 | positive chemotaxis |
| GO:2000251 | positive regulation of actin cytoskeleton reorganization |
| GO:0048842 | positive regulation of axon extension involved in axon guidance |
| GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0051491 | positive regulation of filopodium assembly |
| GO:0051894 | positive regulation of focal adhesion assembly |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| GO:1902336 | positive regulation of retinal ganglion cell axon guidance |
| GO:0051496 | positive regulation of stress fiber assembly |
| GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| GO:0099173 | postsynapse organization |
| GO:1902946 | protein localization to early endosome |
| GO:0032489 | regulation of Cdc42 protein signal transduction |
| GO:0061441 | renal artery morphogenesis |
| GO:0061299 | retina vasculature morphogenesis in camera-type eye |
| GO:0031290 | retinal ganglion cell axon guidance |
| GO:1902287 | semaphorin-plexin signaling pathway involved in axon guidance |
| GO:0097374 | sensory neuron axon guidance |
| GO:0034446 | substrate adhesion-dependent cell spreading |
| GO:0006930 | substrate-dependent cell migration, cell extension |
| GO:0061549 | sympathetic ganglion development |
| GO:0097490 | sympathetic neuron projection extension |
| GO:0097491 | sympathetic neuron projection guidance |
| GO:1901998 | toxin transport |
| GO:0061551 | trigeminal ganglion development |
| GO:0021637 | trigeminal nerve structural organization |
| GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| GO:1902378 | VEGF-activated neuropilin signaling pathway involved in axon guidance |
| GO:0036486 | ventral trunk neural crest cell migration |
| GO:0021649 | vestibulocochlear nerve structural organization |