| Tag | Content |
|---|---|
| Uniprot ID | P97333; Q6PAR3; |
| Entrez ID | 18186 |
| Genbank protein ID | BAA08789.1; EDL11828.1; AAH60129.1; |
| Genbank nucleotide ID | NM_008737.2; XM_006530766.3; |
| Ensembl protein ID | ENSMUSP00000026917 |
| Ensembl nucleotide ID | ENSMUSG00000025810 |
| Gene name | Neuropilin-1 |
| Gene symbol | Nrp1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 22396765 |
| Functional description | Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins (PubMed:26503042). Binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity). |
| Sequence | MERGLPLLCA TLALALALAG AFRSDKCGGT IKIENPGYLT SPGYPHSYHP SEKCEWLIQA 60 PEPYQRIMIN FNPHFDLEDR DCKYDYVEVI DGENEGGRLW GKFCGKIAPS PVVSSGPFLF 120 IKFVSDYETH GAGFSIRYEI FKRGPECSQN YTAPTGVIKS PGFPEKYPNS LECTYIIFAP 180 KMSEIILEFE SFDLEQDSNP PGGMFCRYDR LEIWDGFPEV GPHIGRYCGQ KTPGRIRSSS 240 GVLSMVFYTD SAIAKEGFSA NYSVLQSSIS EDFKCMEALG MESGEIHSDQ ITASSQYGTN 300 WSVERSRLNY PENGWTPGED SYKEWIQVDL GLLRFVTAVG TQGAISKETK KKYYVKTYRV 360 DISSNGEDWI SLKEGNKAII FQGNTNPTDV VLGVFSKPLI TRFVRIKPVS WETGISMRFE 420 VYGCKITDYP CSGMLGMVSG LISDSQITAS NQADRNWMPE NIRLVTSRTG WALPPSPHPY 480 TNEWLQVDLG DEKIVRGVII QGGKHRENKV FMRKFKIAYS NNGSDWKTIM DDSKRKAKSF 540 EGNNNYDTPE LRTFSPLSTR FIRIYPERAT HSGLGLRMEL LGCEVEAPTA GPTTPNGNPV 600 DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTIIDSTIQ SEFPTYGFNC EFGWGSHKTF 660 CHWEHDSHAQ LRWSVLTSKT GPIQDHTGDG NFIYSQADEN QKGKVARLVS PVVYSQSSAH 720 CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ LVWMVVGHQG DHWKEGRVLL HKSLKLYQVI 780 FEGEIGKGNL GGIAVDDISI NNHISQEDCA KPTDLDKKNT EIKIDETGST PGYEGEGEGD 840 KNISRKPGNV LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN 900 FELVDGVKLK KDKLNPQSNY SEA 923 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NRP1 | 102175037 | A0A452DVS7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | NRP1 | 8829 | O14786 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nrp1 | 18186 | P97333 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NRP1 | 450397 | A0A2I3TPR4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Nrp1 | 246331 | Q9QWJ9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | nrp1a | 353246 | Q1RLY9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005021 | vascular endothelial growth factor-activated receptor activity | IMP |
| GO:0005096 | GTPase activator activity | ISO |
| GO:0005515 | protein binding | IPI |
| GO:0008201 | heparin binding | IEA |
| GO:0017154 | semaphorin receptor activity | ISO |
| GO:0017154 | semaphorin receptor activity | IGI |
| GO:0017154 | semaphorin receptor activity | IDA |
| GO:0017154 | semaphorin receptor activity | IPI |
| GO:0019838 | growth factor binding | ISO |
| GO:0019838 | growth factor binding | IPI |
| GO:0019901 | protein kinase binding | IPI |
| GO:0038085 | vascular endothelial growth factor binding | ISO |
| GO:0038085 | vascular endothelial growth factor binding | IPI |
| GO:0046872 | metal ion binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001525 | angiogenesis | ISO |
| GO:0001525 | angiogenesis | IMP |
| GO:0001525 | angiogenesis | IGI |
| GO:0001569 | branching involved in blood vessel morphogenesis | IMP |
| GO:0001764 | neuron migration | IMP |
| GO:0002040 | sprouting angiogenesis | IMP |
| GO:0002042 | cell migration involved in sprouting angiogenesis | IMP |
| GO:0002042 | cell migration involved in sprouting angiogenesis | IC |
| GO:0003148 | outflow tract septum morphogenesis | IMP |
| GO:0006930 | substrate-dependent cell migration, cell extension | ISO |
| GO:0007229 | integrin-mediated signaling pathway | ISO |
| GO:0007229 | integrin-mediated signaling pathway | IMP |
| GO:0007411 | axon guidance | IMP |
| GO:0007411 | axon guidance | IDA |
| GO:0007413 | axonal fasciculation | IMP |
| GO:0007507 | heart development | IGI |
| GO:0008045 | motor neuron axon guidance | IMP |
| GO:0009611 | response to wounding | IEA |
| GO:0010595 | positive regulation of endothelial cell migration | ISO |
| GO:0010595 | positive regulation of endothelial cell migration | IMP |
| GO:0016358 | dendrite development | IMP |
| GO:0016477 | cell migration | IMP |
| GO:0021612 | facial nerve structural organization | IMP |
| GO:0021636 | trigeminal nerve morphogenesis | IMP |
| GO:0021637 | trigeminal nerve structural organization | IMP |
| GO:0021649 | vestibulocochlear nerve structural organization | IMP |
| GO:0021675 | nerve development | IMP |
| GO:0021785 | branchiomotor neuron axon guidance | IMP |
| GO:0021828 | gonadotrophin-releasing hormone neuronal migration to the hypothalamus | IMP |
| GO:0030517 | negative regulation of axon extension | IGI |
| GO:0031290 | retinal ganglion cell axon guidance | IMP |
| GO:0031532 | actin cytoskeleton reorganization | ISO |
| GO:0032489 | regulation of Cdc42 protein signal transduction | ISO |
| GO:0032489 | regulation of Cdc42 protein signal transduction | IMP |
| GO:0034446 | substrate adhesion-dependent cell spreading | ISO |
| GO:0035729 | cellular response to hepatocyte growth factor stimulus | ISO |
| GO:0035767 | endothelial cell chemotaxis | ISO |
| GO:0035924 | cellular response to vascular endothelial growth factor stimulus | IMP |
| GO:0036486 | ventral trunk neural crest cell migration | IMP |
| GO:0038189 | neuropilin signaling pathway | ISO |
| GO:0038189 | neuropilin signaling pathway | IMP |
| GO:0038190 | VEGF-activated neuropilin signaling pathway | ISO |
| GO:0038190 | VEGF-activated neuropilin signaling pathway | IMP |
| GO:0042327 | positive regulation of phosphorylation | ISO |
| GO:0042327 | positive regulation of phosphorylation | IMP |
| GO:0043524 | negative regulation of neuron apoptotic process | IMP |
| GO:0043542 | endothelial cell migration | ISO |
| GO:0043542 | endothelial cell migration | IMP |
| GO:0043547 | positive regulation of GTPase activity | IEA |
| GO:0045766 | positive regulation of angiogenesis | IMP |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway | ISO |
| GO:0048010 | vascular endothelial growth factor receptor signaling pathway | ISO |
| GO:0048010 | vascular endothelial growth factor receptor signaling pathway | IMP |
| GO:0048012 | hepatocyte growth factor receptor signaling pathway | ISO |
| GO:0048485 | sympathetic nervous system development | IMP |
| GO:0048666 | neuron development | IMP |
| GO:0048841 | regulation of axon extension involved in axon guidance | IDA |
| GO:0048842 | positive regulation of axon extension involved in axon guidance | IMP |
| GO:0048843 | negative regulation of axon extension involved in axon guidance | ISO |
| GO:0048843 | negative regulation of axon extension involved in axon guidance | IDA |
| GO:0048844 | artery morphogenesis | IMP |
| GO:0048846 | axon extension involved in axon guidance | IMP |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | ISO |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | IMP |
| GO:0050918 | positive chemotaxis | IMP |
| GO:0051491 | positive regulation of filopodium assembly | ISO |
| GO:0051491 | positive regulation of filopodium assembly | IMP |
| GO:0051496 | positive regulation of stress fiber assembly | ISO |
| GO:0051894 | positive regulation of focal adhesion assembly | ISO |
| GO:0060385 | axonogenesis involved in innervation | IMP |
| GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching | IGI |
| GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching | IMP |
| GO:0060978 | angiogenesis involved in coronary vascular morphogenesis | IMP |
| GO:0060980 | cell migration involved in coronary vasculogenesis | IC |
| GO:0060982 | coronary artery morphogenesis | IMP |
| GO:0061299 | retina vasculature morphogenesis in camera-type eye | IMP |
| GO:0061441 | renal artery morphogenesis | IMP |
| GO:0061549 | sympathetic ganglion development | IMP |
| GO:0061551 | trigeminal ganglion development | IMP |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | IMP |
| GO:0071526 | semaphorin-plexin signaling pathway | IGI |
| GO:0071526 | semaphorin-plexin signaling pathway | IDA |
| GO:0071526 | semaphorin-plexin signaling pathway | IMP |
| GO:0071679 | commissural neuron axon guidance | IMP |
| GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis | IMP |
| GO:0090259 | regulation of retinal ganglion cell axon guidance | IMP |
| GO:0097374 | sensory neuron axon guidance | IMP |
| GO:0097475 | motor neuron migration | IMP |
| GO:0097490 | sympathetic neuron projection extension | IMP |
| GO:0097491 | sympathetic neuron projection guidance | IMP |
| GO:0099173 | postsynapse organization | IDA |
| GO:0099173 | postsynapse organization | IMP |
| GO:0150018 | basal dendrite development | IMP |
| GO:0150020 | basal dendrite arborization | IGI |
| GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | ISO |
| GO:1901166 | neural crest cell migration involved in autonomic nervous system development | IMP |
| GO:1901998 | toxin transport | IMP |
| GO:1902285 | semaphorin-plexin signaling pathway involved in neuron projection guidance | IMP |
| GO:1902287 | semaphorin-plexin signaling pathway involved in axon guidance | IMP |
| GO:1902336 | positive regulation of retinal ganglion cell axon guidance | IMP |
| GO:1902378 | VEGF-activated neuropilin signaling pathway involved in axon guidance | IMP |
| GO:1902946 | protein localization to early endosome | IMP |
| GO:1903375 | facioacoustic ganglion development | IMP |
| GO:1904835 | dorsal root ganglion morphogenesis | IMP |
| GO:1905040 | otic placode development | IMP |
| GO:2000251 | positive regulation of actin cytoskeleton reorganization | ISO |
| GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | IMP |
| GO:0003253 | cardiac neural crest cell migration involved in outflow tract morphogenesis | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005769 | early endosome | IDA |
| GO:0005829 | cytosol | ISO |
| GO:0005883 | neurofilament | IDA |
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IDA |
| GO:0005886 | plasma membrane | TAS |
| GO:0005925 | focal adhesion | ISO |
| GO:0005925 | focal adhesion | IDA |
| GO:0009986 | cell surface | ISO |
| GO:0030424 | axon | ISO |
| GO:0030424 | axon | IDA |
| GO:0030426 | growth cone | ISO |
| GO:0031966 | mitochondrial membrane | IEA |
| GO:0043005 | neuron projection | IDA |
| GO:0043025 | neuronal cell body | ISO |
| GO:0097443 | sorting endosome | IDA |
| GO:0098978 | glutamatergic synapse | IDA |
| GO:0098978 | glutamatergic synapse | IMP |
| GO:0099055 | integral component of postsynaptic membrane | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1266738 | Developmental Biology | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-194138 | Signaling by VEGF | IEA |
| R-MMU-194306 | Neurophilin interactions with VEGF and VEGFR | IEA |
| R-MMU-373755 | Semaphorin interactions | IEA |
| R-MMU-373760 | L1CAM interactions | IEA |
| R-MMU-399954 | Sema3A PAK dependent Axon repulsion | IEA |
| R-MMU-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | IEA |
| R-MMU-399956 | CRMPs in Sema3A signaling | IEA |
| R-MMU-422475 | Axon guidance | IEA |
| R-MMU-445144 | Signal transduction by L1 | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0037 | Angiogenesis |
| KW-0106 | Calcium |
| KW-1003 | Cell membrane |
| KW-0963 | Cytoplasm |
| KW-0217 | Developmental protein |
| KW-0221 | Differentiation |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0357 | Heparan sulfate |
| KW-0358 | Heparin-binding |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0496 | Mitochondrion |
| KW-0524 | Neurogenesis |
| KW-0597 | Phosphoprotein |
| KW-0654 | Proteoglycan |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |