| Tag | Content |
|---|---|
| Uniprot ID | Q9QWJ9 |
| Entrez ID | 246331 |
| Genbank protein ID | AAC53337.1; AAH85689.1; |
| Genbank nucleotide ID | NM_145098.2; XM_006255825.3; |
| Ensembl protein ID | ENSRNOP00000014492; ENSRNOP00000075034; |
| Ensembl nucleotide ID | ENSRNOG00000010744 |
| Gene name | Neuropilin-1 |
| Gene symbol | Nrp1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins (By similarity). Binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity). |
| Sequence | MERGLPLLCA TLALALALAG AFRSDKCGGT IKIENPGYLT SPGYPHSYHP SEKCEWLIQA 60 PEPYQRIMIN FNPHFDLEDR DCKYDYVEVI DGENEGGRLW GKFCGKIAPS PVVSSGPFLF 120 IKFVSDYETH GAGFSIRYEI FKRGPECSQN YTAPTGVIKS PGFPEKYPNS LECTYIIFAP 180 KMSEIILEFE SFDLEQDSNP PGGVFCRYDR LEIWDGFPEV GPHIGRYCGQ KTPGRIRSSS 240 GILSMVFYTD SAIAKEGFSA NYSVLQSSIS EDFKCMEALG MESGEIHSDQ ITASSQYGTN 300 WSVERSRLNY PENGWTPGED SYREWIQVDL GLLRFVTAVG TQGAISKETK KKYYVKTYRV 360 DISSNGEDWI TLKEGNKAII FQGNTNPTDV VFGVFPKPLI TRFVRIKPAS WETGISMRFE 420 VYGCKITDYP CSGMLGMVSG LISDSQITAS NQGDRNWMPE NIRLVTSRTG WALPPSPHPY 480 INEWLQVDLG DEKIVRGVII QGGKHRENKV FMRKFKIAYS NNGSDWKMIM DDSKRKAKSF 540 EGNNNYDTPE LRAFTPLSTR FIRIYPERAT HSGLGLRMEL LGCEVEVPTA GPTTPNGNPV 600 DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTIIDSTIQ SEFPTYGFNC EFGWGSHKTF 660 CHWEHDSHAQ LRWRVLTSKT GPIQDHTGDG NFIYSQADEN QKGKVARLVS PVVYSQSSAH 720 CMTFWYHMSG SHVGTLRVKL HYQKPEEYDQ LVWMVVGHQG DHWKEGRVLL HKSLKLYQVI 780 FEGEIGKGNL GGIAVDDISI NNHIPQEDCA KPTDLDKKNT EIKIDETGST PGYEEGKGDK 840 NISRKPGNVL KTLDPILITI IAMSALGVLL GAVCGVVLYC ACWHNGMSER NLSALENYNF 900 ELVDGVKLKK DKLNPQSNYS EA 922 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NRP1 | 102175037 | A0A452DVS7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | NRP1 | 8829 | O14786 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nrp1 | 18186 | P97333 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NRP1 | 450397 | A0A2I3TPR4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Nrp1 | 246331 | Q9QWJ9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | nrp1a | 353246 | Q1RLY9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0030424 | axon |
| GO:0009986 | cell surface |
| GO:0005829 | cytosol |
| GO:0005769 | early endosome |
| GO:0005925 | focal adhesion |
| GO:0098978 | glutamatergic synapse |
| GO:0030426 | growth cone |
| GO:0016021 | integral component of membrane |
| GO:0099055 | integral component of postsynaptic membrane |
| GO:0031966 | mitochondrial membrane |
| GO:0005883 | neurofilament |
| GO:0043005 | neuron projection |
| GO:0043025 | neuronal cell body |
| GO:0005886 | plasma membrane |
| GO:0097443 | sorting endosome |
| GO:0019838 | growth factor binding |
| GO:0005096 | GTPase activator activity |
| GO:0008201 | heparin binding |
| GO:0046872 | metal ion binding |
| GO:0019901 | protein kinase binding |
| GO:0017154 | semaphorin receptor activity |
| GO:0038085 | vascular endothelial growth factor binding |
| GO:0005021 | vascular endothelial growth factor-activated receptor activity |
| GO:0031532 | actin cytoskeleton reorganization |
| GO:0001525 | angiogenesis |
| GO:0060978 | angiogenesis involved in coronary vascular morphogenesis |
| GO:0048844 | artery morphogenesis |
| GO:0048846 | axon extension involved in axon guidance |
| GO:0007411 | axon guidance |
| GO:0007413 | axonal fasciculation |
| GO:0060385 | axonogenesis involved in innervation |
| GO:0150020 | basal dendrite arborization |
| GO:0150018 | basal dendrite development |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0021785 | branchiomotor neuron axon guidance |
| GO:0016477 | cell migration |
| GO:0002042 | cell migration involved in sprouting angiogenesis |
| GO:0035729 | cellular response to hepatocyte growth factor stimulus |
| GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| GO:0071679 | commissural neuron axon guidance |
| GO:0060982 | coronary artery morphogenesis |
| GO:0016358 | dendrite development |
| GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching |
| GO:1904835 | dorsal root ganglion morphogenesis |
| GO:0035767 | endothelial cell chemotaxis |
| GO:0043542 | endothelial cell migration |
| GO:0021612 | facial nerve structural organization |
| GO:1903375 | facioacoustic ganglion development |
| GO:0021828 | gonadotrophin-releasing hormone neuronal migration to the hypothalamus |
| GO:0007507 | heart development |
| GO:0048012 | hepatocyte growth factor receptor signaling pathway |
| GO:0007229 | integrin-mediated signaling pathway |
| GO:0008045 | motor neuron axon guidance |
| GO:0097475 | motor neuron migration |
| GO:0030517 | negative regulation of axon extension |
| GO:0048843 | negative regulation of axon extension involved in axon guidance |
| GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| GO:0043524 | negative regulation of neuron apoptotic process |
| GO:0021675 | nerve development |
| GO:0007399 | nervous system development |
| GO:1901166 | neural crest cell migration involved in autonomic nervous system development |
| GO:0048666 | neuron development |
| GO:0001764 | neuron migration |
| GO:0038189 | neuropilin signaling pathway |
| GO:1905040 | otic placode development |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| GO:0050918 | positive chemotaxis |
| GO:2000251 | positive regulation of actin cytoskeleton reorganization |
| GO:0045766 | positive regulation of angiogenesis |
| GO:0048842 | positive regulation of axon extension involved in axon guidance |
| GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis |
| GO:0010595 | positive regulation of endothelial cell migration |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0051491 | positive regulation of filopodium assembly |
| GO:0051894 | positive regulation of focal adhesion assembly |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| GO:0042327 | positive regulation of phosphorylation |
| GO:1902336 | positive regulation of retinal ganglion cell axon guidance |
| GO:0051496 | positive regulation of stress fiber assembly |
| GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| GO:0099173 | postsynapse organization |
| GO:1902946 | protein localization to early endosome |
| GO:0048841 | regulation of axon extension involved in axon guidance |
| GO:0032489 | regulation of Cdc42 protein signal transduction |
| GO:0090259 | regulation of retinal ganglion cell axon guidance |
| GO:0061441 | renal artery morphogenesis |
| GO:0009611 | response to wounding |
| GO:0061299 | retina vasculature morphogenesis in camera-type eye |
| GO:0031290 | retinal ganglion cell axon guidance |
| GO:0071526 | semaphorin-plexin signaling pathway |
| GO:1902287 | semaphorin-plexin signaling pathway involved in axon guidance |
| GO:1902285 | semaphorin-plexin signaling pathway involved in neuron projection guidance |
| GO:0097374 | sensory neuron axon guidance |
| GO:0002040 | sprouting angiogenesis |
| GO:0034446 | substrate adhesion-dependent cell spreading |
| GO:0006930 | substrate-dependent cell migration, cell extension |
| GO:0061549 | sympathetic ganglion development |
| GO:0048485 | sympathetic nervous system development |
| GO:0097490 | sympathetic neuron projection extension |
| GO:0097491 | sympathetic neuron projection guidance |
| GO:1901998 | toxin transport |
| GO:0061551 | trigeminal ganglion development |
| GO:0021636 | trigeminal nerve morphogenesis |
| GO:0021637 | trigeminal nerve structural organization |
| GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| GO:0038190 | VEGF-activated neuropilin signaling pathway |
| GO:1902378 | VEGF-activated neuropilin signaling pathway involved in axon guidance |
| GO:0036486 | ventral trunk neural crest cell migration |
| GO:0021649 | vestibulocochlear nerve structural organization |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0037 | Angiogenesis |
| KW-0106 | Calcium |
| KW-1003 | Cell membrane |
| KW-0963 | Cytoplasm |
| KW-0217 | Developmental protein |
| KW-0221 | Differentiation |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0357 | Heparan sulfate |
| KW-0358 | Heparin-binding |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0496 | Mitochondrion |
| KW-0524 | Neurogenesis |
| KW-0597 | Phosphoprotein |
| KW-0654 | Proteoglycan |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |