| Tag | Content |
|---|---|
| Uniprot ID | Q1RLY9 |
| Entrez ID | 353246 |
| Genbank protein ID | AAI15225.1 |
| Genbank nucleotide ID | NM_001040326.1 |
| Ensembl protein ID | ENSDARP00000141420 |
| Ensembl nucleotide ID | ENSDARG00000102153 |
| Gene name | Neuropilin |
| Gene symbol | nrp1a |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MHCGLVLILF TGIFLIVSAL KNDKCGDNIR ITSANYLTSP GYPVSYYPSQ KCIWVITAPG 60 PNQRILINFN PHFDLEDREC KYDYVEVRDG VDENGQLVGK YCGKIAPSPV VSSGNQLFIK 120 FVSDYETHGA GFSIRYEIFK TGPECSRNFT SSSGVIKSPG FPEKYPNNLD CTFMIFAPKM 180 SEIVLEFESF ELEPDTQPPA GVFCRYDRLE IWDGFPGVGP YIGRYCGQNT PGRIISYTGT 240 LAMTINTDSA IAKEGFSANF TVLERTVPDD FDCTEPLGME TGEIHSDQIM ASSQYSNSWS 300 AERSRLNNPE NGWTPLEDTN KEWIQVDLGF LRFVSAIGTQ GAISQETKKK YYVKEYKVDV 360 SSNGEDWITI KDGPKQKLFQ GNTNPTDVVK AKFPKPTLTR YLRIRPINWE TGIALRFEVY 420 GCKISEYPCS GMLGMVSGLI TDSQITVSSH IERTWVSENA RLMTSRSGWM LLPQSQPYAD 480 EWLQIDLAEE KLVKGLIIQG GKHRDNKVFM KKFRLGYSNN GSDWKLVMDA TGNKPKIFEG 540 NLNYDTPALR TMEPVLTRFV RIYPDRGTPA GMGLRLELLG CEMEVPTVPP TTPAASTTPS 600 DECDDDQANC HSGTGGTTAT ETIREMSTIP AFLWFACDFG WANDPSFCGW ISEDSGFRWQ 660 IQSSGTPTLN TGPNMDHTGG SGNFIYTLAT GAQETEVARL VSPSVSGQDS DLCLSFWYHM 720 FGSHIGTLHI KQRRETSQGS ADVLLWTVSG HQGNRWREGR VLIPHSNKPY QVIIESVVER 780 KSWGDIAVDD IKILDNVNMA DCKDPDVPAE PIQPEDNFNE IMVDITDFPD IVENPDIGGA 840 GNMLKTLDPI LITIIAMSAL GVFLGAICGV VLYCACSHSG MSDRNLSALE NYNFELVDGV 900 KLKKDKLNSQ NSYSEA 916 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NRP1 | 102175037 | A0A452DVS7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | NRP1 | 8829 | O14786 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nrp1 | 18186 | P97333 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NRP1 | 450397 | A0A2I3TPR4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Nrp1 | 246331 | Q9QWJ9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | nrp1a | 353246 | Q1RLY9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0019838 | growth factor binding |
| GO:0008201 | heparin binding |
| GO:0046872 | metal ion binding |
| GO:0017154 | semaphorin receptor activity |
| GO:0005021 | vascular endothelial growth factor-activated receptor activity |
| GO:0001525 | angiogenesis |
| GO:0009887 | animal organ morphogenesis |
| GO:0007411 | axon guidance |
| GO:0035767 | endothelial cell chemotaxis |
| GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-0037 | Angiogenesis |
| KW-0106 | Calcium |
| KW-0217 | Developmental protein |
| KW-0221 | Differentiation |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0357 | Heparan sulfate |
| KW-0358 | Heparin-binding |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0524 | Neurogenesis |
| KW-0654 | Proteoglycan |
| KW-1267 | Proteomics identification |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |