| Tag | Content |
|---|---|
| Uniprot ID | A0A452DYE9 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000004791 |
| Ensembl nucleotide ID | ENSCHIG00000008763 |
| Gene name | Sema domain-containing protein |
| Gene symbol | PLXND1 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MARRAAGGAP LSARAAAASP LPPRPPFRAP QCPPPPPPLW LLLLLGAARV GALEIQRRFP 60 SPTPTNNFAL DGAAGTVYLA AVNRLYQLSG ANLSLEAEAA VGPVADSPLC HAPQLPQASC 120 EHPRRLTDNY NKILQLDPGQ GLVVVCGSVY QGFCQLRRRG NISAVAVPFP PAAPPAAPVT 180 VFPSMLNVAA NHPNASTVGL LLPPAAGAGG SRLLVGATYT GYGSAFFPRN RSLEDHRFEN 240 TPEIAIRSLD ARGDLAKLFT FDLNPSDDNI LKIKQGAKEQ HKLGFVRAFL HPPDPRPGAQ 300 TYAYLALNSE ARAGDKESQA RSLLARICLP RGAGGDAKKL TESYIQLGLQ CAGGAGRGDL 360 YSRLVSVFPT RELLFAVFER PQGTPGARAA PAALCAFRFA DVQAAIRAAR TACFVDPAPD 420 VVAVLDSVVQ GTGPACERKR NIQLQPEQLD CGAAHLQHPL SVLQPLKALP VFRAPGLSSV 480 AVASVGNYTV VFLGTVSGRL LKVNLNESMQ VVSRKVVTVA YGEPVHHVMQ FDPVDPGYLY 540 LMTSHQMARV KVAACAVHTT CGDCVGTADA YCGWCTLETR CTLRQDCANS SQPHFWTSAS 600 AGPSRCPAMT VLPAEINVHQ EYPGMILQIS GSLPSLSGME MACDYGHGIR TVARVPGPAF 660 GHQIAYCNLL PRDQFPPFPP HQDHVTVEMS VRVQGQSIVR ASFTIYDCGR VGQVYPHTAC 720 TSCLSAQWPC FWCAQQHACV SNQSRCEASP NPTVSQAQGC PLPPLFFFFH LAPGAVGAAW 780 TPPDPRVLQG AALECSFGLE ETFEAVWVNE SAVRCKQVVL HTTQKSQVFP LSLQLKGRPA 840 RFLDSPDPMT VEVYNCAVGS PDCSQCLGRE DLGHLCVWSD GCRPRGTMQP LPGTCPAPEI 900 RPHPPVSPIP LSGPLDGGTQ LTIRGRNLGR RFSDVAHGVW IGSVACEPLA DRYTVSEEIV 960 CATGPATEAF SDVVTVNASK EGRSQERFSY VVRESPMGPK AGGTRITIHG SDLHVGSELQ 1020 VLVNNTEPCT ELLRSDASIA CTVPGGSLPA VVPVCVRFEQ RGCVHGGLSF QYMPNPVITA 1080 ISPHRSHVSG GRTITVAGER FHMVQKVSMA VHHIGREPTL CKVLNSTLIT CPSPGALSNA 1140 SAPVDFFLNG RVYADEAVVA EELLEPEEAQ RGSQFRLDYL PDPQFSTAKR EKWIKHHPGE 1200 PLTLVIHKEQ DGLGLESHEY RVKIGQVACD IQIVSERVIH CSVNESLGTA EGQLPITIQV 1260 GNFNQTIATL QLGGSETAII VSIVICSVLL LLSVVALFVF CTKSRRAERY WQKTLLQMEE 1320 MESQIREEIR KGFAELQTDM TDLTKELNRS QGIPFLEYKH FVTRTFFPKC SSLYEERYVL 1380 PSQTLNSQGS SPVQETHPLL GEWKIPESCR PNMEEGISLF SSLLNNKHFL IVFVHALEQQ 1440 KDFAVRDRCS LASLLTIALH GKLEYYTGIM KELLVDLIDA SAAKNPKLML RRTESVVEKM 1500 LTNWMSICMY SCLRETVGEP FFLLLCAIKQ QINKGSIDAI TGKARYTLNE EWLLRENIEA 1560 KPRNLNVSFQ GCGMDSLSVR AMDTDTLTQV KEKILEAFCK NVPYSQWPRA EDVDLEWFAS 1620 STQSYILRDL DDTSVVEDGR KKLNTLAHYK IPEGASLAMS LTDKKDNTLG RVKDLDTEKY 1680 FHLVLPTDEL AEPKKSHRQS HRKKVLPEIY LTRLLSTKGT LQKFLDDLFK AILSIREDKP 1740 PLAVKYFFDF LEEQAEKRGI SDPDTLHIWK TNRWGALRGS GKGQGCFTGS RSLLSPPGVL 1800 LPGSCPPTQD SPTNKLLYAK EIPEYRKIVQ RYYKQIHDMT PLSEQEMNAH LAEESRKYQN 1860 EFNTNVAMAE IYKYAKRYRP QIVSALEANP TARRTQLQHK FEQVVALMED NIYECYSEA 1919 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PLXND1 | E2RDE1 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | PLXND1 | A0A452DYE9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PLXND1 | 23129 | Q9Y4D7 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Plxnd1 | 67784 | Q3UH93 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PLXND1 | 460687 | H2QNC7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Plxnd1 | 312652 | D4AA77 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0017154 | semaphorin receptor activity |
| InterPro ID | InterPro Term |
|---|---|
| IPR013783 | Ig-like_fold |
| IPR014756 | Ig_E-set |
| IPR002909 | IPT_dom |
| IPR031148 | Plexin |
| IPR042719 | Plexin-D1_Sema |
| IPR013548 | Plexin_cytoplasmic_RasGAP_dom |
| IPR002165 | Plexin_repeat |
| IPR016201 | PSI |
| IPR008936 | Rho_GTPase_activation_prot |
| IPR001627 | Semap_dom |
| IPR036352 | Semap_dom_sf |
| IPR041019 | TIG1_plexin |
| IPR015943 | WD40/YVTN_repeat-like_dom_sf |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51004 | SEMA |