| Tag | Content |
|---|---|
| Uniprot ID | Q3UH93; Q68HV1; |
| Entrez ID | 67784 |
| Genbank protein ID | BAE27964.1; AAT99561.1; |
| Genbank nucleotide ID | NM_026376.3 |
| Ensembl protein ID | ENSMUSP00000015511 |
| Ensembl nucleotide ID | ENSMUSG00000030123 |
| Gene name | Plexin-D1 |
| Gene symbol | Plxnd1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 25807483 |
| Functional description | Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Mediates anti-angiogenic signaling in response to SEMA3E. Required for normal development of the heart and vasculature. |
| Sequence | MARRAAGGAP PSARAAAAVP LRPRPHSRGP GLLPLPLLLL LGAARAGALE IQRRFPSPTP 60 TNNFALDGTA GTVYLAAVNR LYQLSSANLS LEAEATVGPV PDSPLCHAPQ LPQASCEHPR 120 RLTDNYNKIL QLDPGQGLVV ACGSIYQGLC QLRRRGNISA LAVSFPPAAP TAEPVTVFPS 180 MLNVAANHPN ASTVGLVLPP TSGTGGSRLL VGATYTGFGS AFFPRNRSLE DHRFENTPEI 240 AIRSLDARGD LAKLFTFDLN PSDDNILKIK QGAKEQHKLG FVRAFLHPAV PPHSAQPYAY 300 LALNSEARAG DKDSQARSLL ARICLPRGAG GDAKKLTESY IQLGLQCAGG AGRGDLYSRL 360 VSVFPAREQF FAVFERPQGA PGARNAPAAL CAFRFDDVQA AIRAARTACF VEPAPDVVAV 420 LDSVVQGTGP ACESKRNIQL QPEQLDCGAA HLQHPLTILQ PLRASPVFRA PGLTAVAVAS 480 ANNYTAVFLG TATGRLLKIS LNESMQVVSR RVLTVAYGEP VHHVMQFDPM DPGYLYLMTS 540 HQMARVKVAA CEVHSTCGDC VGAADAYCGW CTLETRCTLQ QDCTNSSQPH FWTSASEGPS 600 RCPAMTVLPS EIDVHRDYTG MILQISGSLP SLSGMEMACD YGNGVRTVAR VPGPAYDHQI 660 AYCNLLPRAQ FPSFPAGQDH VTVEMSVRVK GHNIVSANFT IYDCSRIGQV YPHTACTSCL 720 STQWPCSWCI QLHSCVSNQS QCQDSPNPTS PQDCPQILPS PLAPVPTGGS QDILVPLTKA 780 TFFHGSSLEC SFGLEESFEA VWANNSLVRC NQVVLHTTQK SQVFPLSLKL KGPPDRFLDS 840 PNPMTVVVYN CAMGSPDCSQ CLGREDLGHL CVWNDGCRLR GPLQPLPGTC PAPEIRAIEP 900 LSGPLDGGTL LTIRGRNLGR RLSDVAHGVW IGSVACEPLA DRYTVSEEIV CATGPAAGAF 960 SDVVTVNVSK EGRSREQFSY VLPTVHSLEP SMGPKAGGTR ITIHGSDLNV GSMLQVLVND 1020 TDPCTDLTRT ATSITCTVPG GTLPSPVPVC VRFESRGCVH GNLTFWYMQN PVITAISPGR 1080 SPVSGGRTIT VAGERFHMVQ NVSMAVHHIG REPTFCKVLN STLITCPSPG ALSNASAPVD 1140 FFINGRAYAD EAAEELLDPA EAQRGSRFRL DYLPNPQFST AKREKWIKHH PGEPLTLVIH 1200 KEQDSLGLES HEYHIKIGQV SCDIQIISDR VIHCSVNESL GTAEGQLPIT IQVGNFNQTI 1260 ATLQLGGSET AIVVSIVICS VLLLLSVVAL FVFCTKSRRA ERYWQKTLLQ MEEMESQIRE 1320 EIRKGFAELQ TDMTDLTKEL NRSQGIPFLE YKHFVTRTFF PKCSSLYEER YVLPSKTLNS 1380 QGGSPPQETH PLLGEWNIPE HCRPSMEEGI SLFSSLLNNK HFLIVFVHAL EQQKDFAVRD 1440 RCSLASLLTI ALHGKLEYYT SIMKELLVDL IDASAAKNPK LMLRRTESVV EKMLTNWMSI 1500 CMYGCLRETV GEPFFLLLCA IKQQINKGSI DAITGKARYT LNEEWLLREN IEAKPRNLNV 1560 SFQGCGMDSL SVRAMDTDTL TQVKEKILEA FCKNVPYSQW PRAEDVDLEW FASSTQSYVL 1620 RDLDDTSVVE DGRKKLNTLA HYKIPEGASL AMSLTDKKDS TLGRVKDLDT EKYFHLVLPT 1680 DELVEPKKSH RQSHRKKVLP EIYLTRLLST KGTLQKFLDD LFKAILSIRE DKPPLAVKYF 1740 FDFLEEQAEK RGISDPDTLH IWKTNSLPLR FWVNILKNPQ FVFDIEKTDH IDACLSVIAQ 1800 AFIDACSISD LQLGKDSPTN KLLYAKEIPE YRKTVQRYYK QIQDMTPLSE QEMNAHLAEE 1860 SRKYQNEFNT NVAMAEIYKY AKRYRPQIMA ALEANPTARR TQLQHKFEQV VALMENNIYE 1920 CYSEA 1925 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PLXND1 | E2RDE1 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | PLXND1 | A0A452DYE9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PLXND1 | 23129 | Q9Y4D7 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Plxnd1 | 67784 | Q3UH93 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PLXND1 | 460687 | H2QNC7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Plxnd1 | 312652 | D4AA77 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0017154 | semaphorin receptor activity | IPI |
| GO:0017154 | semaphorin receptor activity | IDA |
| GO:0017154 | semaphorin receptor activity | IBA |
| GO:0019904 | protein domain specific binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001525 | angiogenesis | IMP |
| GO:0001569 | branching involved in blood vessel morphogenesis | IMP |
| GO:0003151 | outflow tract morphogenesis | IMP |
| GO:0003151 | outflow tract morphogenesis | TAS |
| GO:0003279 | cardiac septum development | IMP |
| GO:0007162 | negative regulation of cell adhesion | IBA |
| GO:0007416 | synapse assembly | IMP |
| GO:0008360 | regulation of cell shape | IBA |
| GO:0030334 | regulation of cell migration | IMP |
| GO:0030334 | regulation of cell migration | IBA |
| GO:0032092 | positive regulation of protein binding | IDA |
| GO:0035904 | aorta development | IMP |
| GO:0043087 | regulation of GTPase activity | IBA |
| GO:0043542 | endothelial cell migration | IMP |
| GO:0043542 | endothelial cell migration | IBA |
| GO:0045765 | regulation of angiogenesis | IMP |
| GO:0050772 | positive regulation of axonogenesis | IBA |
| GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching | IDA |
| GO:0060976 | coronary vasculature development | IMP |
| GO:0071526 | semaphorin-plexin signaling pathway | IGI |
| GO:0071526 | semaphorin-plexin signaling pathway | IMP |
| GO:1902287 | semaphorin-plexin signaling pathway involved in axon guidance | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0002116 | semaphorin receptor complex | IBA |
| GO:0005886 | plasma membrane | IC |
| GO:0005887 | integral component of plasma membrane | IDA |
| GO:0005887 | integral component of plasma membrane | IBA |
| GO:0030027 | lamellipodium | ISO |
| GO:0031258 | lamellipodium membrane | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1266738 | Developmental Biology | IEA |
| R-MMU-373755 | Semaphorin interactions | IEA |
| R-MMU-416700 | Other semaphorin interactions | IEA |
| R-MMU-422475 | Axon guidance | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0037 | Angiogenesis |
| KW-1003 | Cell membrane |
| KW-0966 | Cell projection |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0472 | Membrane |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| InterPro ID | InterPro Term |
|---|---|
| IPR013783 | Ig-like_fold |
| IPR014756 | Ig_E-set |
| IPR002909 | IPT_dom |
| IPR031148 | Plexin |
| IPR042719 | Plexin-D1_Sema |
| IPR013548 | Plexin_cytoplasmic_RasGAP_dom |
| IPR002165 | Plexin_repeat |
| IPR016201 | PSI |
| IPR008936 | Rho_GTPase_activation_prot |
| IPR001627 | Semap_dom |
| IPR036352 | Semap_dom_sf |
| IPR041019 | TIG1_plexin |
| IPR015943 | WD40/YVTN_repeat-like_dom_sf |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51004 | SEMA |