| Tag | Content |
|---|---|
| Uniprot ID | E2RDE1 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCAFP00000006907 |
| Ensembl nucleotide ID | ENSCAFG00000004613 |
| Gene name | Plexin D1 |
| Gene symbol | PLXND1 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MARRAAGGAP HSARAAAASP PPPRPPRRAP RPCPLLPPLL LLLGAARAGA LEVQRRFPSP 60 TPTNNFALDG AAGTVYLAAV NRLYQLSGAN LSLEAEAAVG PVADSPLCHA PQLPQASCEH 120 PRRLTDNYNK ILQLDPGQGL VVACGSIYQG FCQLRRRGNI SAVAVRFPPA APPAEPVTVF 180 PSMLNVAANH PNASTVGLVL PPAAGSGGSR LLVGATYTGY GSAFFPRNRS LEDHRFENTP 240 EIAIRSLDAR GDLAKLFTFD LNPSDDNILK IKQGAKEQHK LGFVRAFLHP PEPPPGAPSY 300 AYLALNSEAR AGDKESQARS LLARICLPRG AGGDAKKLTE SYIQLGLQCA GGAGRGDLYS 360 RLVSVFPARE LLFAVFERPQ GSPAARATPA ALCAFRFADV QAAIRAARNA CFVEPAPDVV 420 AVLDSVVQGT GPACERKRNI QLQPEQLDCG AAHLQHPLSI LQPLKATPVF RAPGLSSVAV 480 ASVSNYTVVF LGTVSGRLLK INLNESMQVV SRRAVTVAYG EPVHHVMQFD PADPGYLYLM 540 TSHQMARVKV AACAVHTTCG DCVGAADAYC GWCALETRCT LQQDCANSSQ RHFWTSASEG 600 PSRCPTMTVL PAEIDVHQEY SGMILQISGS LPSLSGMEMA CDYGNNIRTV ARVPGPAFDH 660 QIAYCNLLPR DQFPPFPPHQ DHVIVEMSVR VNGRNIVRAD FTIYNCSRVG QVYPHTACTS 720 CLSAQWPCFW CAQQHACVSN QSRCEASPNP MNPQDCPQIL PSALAPMPTG SSQSIPVHLA 780 NAAFQGAALE CSFGPEEVFE AIWVNESTVH CNQVGLHTTQ KSQVFPLSLQ LKGQPARFLD 840 SPDPMTVEVY NCAMGSPDCS QCLGREDLGH LCVWSDGCRL RGPLQPLPGT CPAPEIRTIE 900 PLSGPLDGGT LLTIRGRNLG RRLSDVAHGV WVGSVACEPL ANRYTVSEEI VCATGPAPGP 960 FSDVVTVNAS KEGKSRERFS YVLPLVQFLE PDKGPKAGGT RIIIHGSDLH VGSELQVLVN 1020 DTEPCTELVR TEASITCTVP EGALPAPVPV CVRFERRGCV RSNLTFQYMQ NPVITAISPR 1080 RSPVSGGRTI TVAGERFHMV QNVSMAVHHI GREPTLCKVL NSTLITCPSP GALSNASAPV 1140 DFFINGRAYA DEAAVAEELL DPDEARRGSR FRLDYLPDPQ FSTAKREKWI KHHPGEPLTL 1200 VIHKEQDSLG LESHEYRIKI GQVACDIQIV SDRVIHCSVN ESLGTAEGQL PITIQVGNFN 1260 QTIATLQLGG SETAIIVSIV ICSVLLLLSV VALFVFCTKS RRAERYWQKT LLQMEEMESQ 1320 IREEIRKGFA ELQTDMTDLT KELNRSQGIP FLEYKHFVTR TFFPKCSSLY EERYVLPSQT 1380 LNSQGSCPVQ ETHPLLGEWK IPESCRPNME EGISLFSSLL NNKHFLIVFV HALEQQKDFA 1440 VRDRCSLASL LTIALHGKLE YYTGIMKELL VDLIDASAAK NPKLMLRRTE SVVEKMLTNW 1500 MSICMYSCLR ETVGEPFFLL LCAIKQQINK GSIDAITGKA RYTLNEEWLL RENIEAKPRN 1560 LNVSFQGCGM DSLSVRAMDT DTLTQVKEKI LEAFCKNVPY SQWPRAEDVD LEWFASSTQS 1620 YILRDLDDTS VVEDGRKKLN TLAHYKIPEG ASLAMSLTDK KDNTLGRVKD LDTEKYFHLV 1680 LPTDELAEPK KSHRQSHRKK VLPEIYLTRL LSTKGTLQKF LDDLFKAILS IREDKPPLAV 1740 KYFFDFLEEQ AEKRGISDPD TLHIWKTNSL PLRFWVNILK NPQFVFDIDK TDHIDACLSV 1800 IAQAFIDACS ISDLQLGKDS PTNKLLYAKE IPEYRKIVQR YYKQIHDMTP LSEQEMNAHL 1860 AEESRKYQNE FNTNVAMAEI YKYAKRYRTQ IMTALEANPT ARRTQLQHKF EQVVALMEDN 1920 IYECYSEA 1928 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PLXND1 | E2RDE1 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | PLXND1 | A0A452DYE9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PLXND1 | 23129 | Q9Y4D7 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Plxnd1 | 67784 | Q3UH93 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PLXND1 | 460687 | H2QNC7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Plxnd1 | 312652 | D4AA77 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005887 | integral component of plasma membrane |
| GO:0030027 | lamellipodium |
| GO:0002116 | semaphorin receptor complex |
| GO:0019904 | protein domain specific binding |
| GO:0017154 | semaphorin receptor activity |
| GO:0035904 | aorta development |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0003279 | cardiac septum development |
| GO:0060976 | coronary vasculature development |
| GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching |
| GO:0043542 | endothelial cell migration |
| GO:0007162 | negative regulation of cell adhesion |
| GO:0003151 | outflow tract morphogenesis |
| GO:0050772 | positive regulation of axonogenesis |
| GO:0032092 | positive regulation of protein binding |
| GO:0045765 | regulation of angiogenesis |
| GO:0030334 | regulation of cell migration |
| GO:0008360 | regulation of cell shape |
| GO:0043087 | regulation of GTPase activity |
| GO:1902287 | semaphorin-plexin signaling pathway involved in axon guidance |
| GO:0007416 | synapse assembly |
| InterPro ID | InterPro Term |
|---|---|
| IPR013783 | Ig-like_fold |
| IPR014756 | Ig_E-set |
| IPR002909 | IPT_dom |
| IPR031148 | Plexin |
| IPR042719 | Plexin-D1_Sema |
| IPR013548 | Plexin_cytoplasmic_RasGAP_dom |
| IPR002165 | Plexin_repeat |
| IPR016201 | PSI |
| IPR008936 | Rho_GTPase_activation_prot |
| IPR001627 | Semap_dom |
| IPR036352 | Semap_dom_sf |
| IPR041019 | TIG1_plexin |
| IPR015943 | WD40/YVTN_repeat-like_dom_sf |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51004 | SEMA |