| Tag | Content |
|---|---|
| Uniprot ID | D4AA77 |
| Entrez ID | 312652 |
| Genbank protein ID | EDM02133.1 |
| Genbank nucleotide ID | NM_001107881.1 |
| Ensembl protein ID | ENSRNOP00000033101 |
| Ensembl nucleotide ID | ENSRNOG00000025209 |
| Gene name | Plexin D1 |
| Gene symbol | Plxnd1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MLNVAANHPN ASTVGLVLPP ASGTGGSRLL VGATYTGYGS AFFPRNRSLE DHRFENTPEI 60 SIRSLDARGD LAKLFTFDLN PSDDNILKIK QGAKEQHKLG FVRAFLHPAV PPHSAHPYAY 120 LALNSEARAG DKDSQARSLL ARICLPRGAG GDAKKLTESY IQLGLQCAGG AGRGDLYSRL 180 VSVFPAREQF FAVFERPQGT PGARNAPAAL CAFRFADVQA AIRAARTACF LQPEQLDCGA 240 AHLQHPLTIL QPLRASPVFR APGLTAVAVA NANNYTAVFL GTATGRLLKI SLNESMQVVS 300 RRVLTVAYGE PVHHVMQFDP MDPGYLYLMT SHQMARVKVA ACEVHSTCGD CVGAADAYCG 360 WCTLETRCTF KQDCANSSLP HFWTSASEGP SRCPAMTVLP SEIDVHRDYT GMILQISGSL 420 PSLSGMEMAC DYGNGVRTVA RVPGPAYGHQ IAYCNLLPRA QFPPFPAGQD HVTVEMSVRV 480 KGHNIVSANF TIYDCSRIGQ VYPHTACTSC LSTQWPCSWC IQLHSCVSNQ SRCQDSPNPT 540 SPQDCPQIVP SPLAPVPTGG SQDILVPLTK AAFFHGTSLQ CSFGLEENFE AVWANDSLVR 600 CNQVVLHTTQ KSQVFPLSLK LKGPPDRFLD SPNPMTVVVY NCAMGSPDCS QCLGREDLGH 660 LCVWNDGCRL RGPLQPLSGT CPAPEIRAIE PLSGPLNGGT LLTIRGKNLG RRLSDVAHGV 720 WIGNVACEPL ADRYTVSEEI VCATGPAPGA FSDVVTVNVS KEGRSREQFS YVLPRVHSLE 780 PSMGPKAGGT RITIHGSDLN VGSMLQVLVN DTDPCTDLTR TATSITCTVP RGTLPSPVPV 840 CVRFESRGCV HGNLTFWYMQ NPVITAISPG RSPVSGGRTI TVAGERFHMV QNVSMAVHHI 900 GREPTFCKVL NSTLIICPSP GALSNASAPV DFFINGRAYA DEAAEELLDP AEAQRGSRFR 960 LDYLPNPQFS TAKREKWIKH HPGEPLTLVI HKEQDSLGLE SHEYHIKIGQ VSCDIQIISD 1020 RVIHCSVNES LGTAEGQLPI TIQVGNFNQT IATLQLGGSE TAIVVSIVIC SVLLLLSVVA 1080 LFVFCTKSRR AERYWQKTLL QMEEMESQIR EEIRKGFAEL QTDMTDLTKE LNRSQGIPFL 1140 EYKHFVTRTF FPKCSSLYEE RYVLPSKTLN SQGGSPPQET HPLLGEWNIP EHCRPSMEEG 1200 ISLFSSLLNN KHFLIVFVHA LEQQKDFAVR DRCSLASLLT IALHGKLEYY TSIMKELLVD 1260 LIDASAAKNP KLMLRRTESV VEKMLTNWMS ICMYGCLRET VGEPFFLLLC AIKQQINKGS 1320 IDAITGKARY TLNEEWLLRE NIEAKPRNLN VSFQGCGMDS LSVRAMDTDT LTQVKEKILE 1380 AFCKNVPYSQ WPRAEDVDLE WFASSTQSYV LRDLDDTSVV EDGRKKLNTL AHYKIPEGAS 1440 LAMSLTDKKD NTLGRVKDLD TEKYFHLVLP TDELVEPKKS HRQSHRKKVL PEIYLTRLLS 1500 TKGTLQKFLD DLFKAILSIR EDKPPLAVKY FFDFLEEQAE KRGISDPDTL HIWKTNSLPL 1560 RFWVNILKNP QFVFDIEKTD HIDACLSVIA QAFIDACSIS DLQLGKDSPT NKLLYAKEIP 1620 EYRKIVQRYY KQIQDMTPLS EQEMNAHLAE ESRKYQNEFN TNVAMAEIYK YAKRYRPQIM 1680 AALEANPTAR RTQLQYKFEQ VVALMENNIY ECYSEA 1716 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PLXND1 | E2RDE1 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | PLXND1 | A0A452DYE9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PLXND1 | 23129 | Q9Y4D7 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Plxnd1 | 67784 | Q3UH93 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PLXND1 | 460687 | H2QNC7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Plxnd1 | 312652 | D4AA77 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005887 | integral component of plasma membrane |
| GO:0030027 | lamellipodium |
| GO:0002116 | semaphorin receptor complex |
| GO:0019904 | protein domain specific binding |
| GO:0017154 | semaphorin receptor activity |
| GO:0001525 | angiogenesis |
| GO:0035904 | aorta development |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0003279 | cardiac septum development |
| GO:0060976 | coronary vasculature development |
| GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching |
| GO:0043542 | endothelial cell migration |
| GO:0007162 | negative regulation of cell adhesion |
| GO:0003151 | outflow tract morphogenesis |
| GO:0050772 | positive regulation of axonogenesis |
| GO:0032092 | positive regulation of protein binding |
| GO:0045765 | regulation of angiogenesis |
| GO:0030334 | regulation of cell migration |
| GO:0008360 | regulation of cell shape |
| GO:0043087 | regulation of GTPase activity |
| GO:0071526 | semaphorin-plexin signaling pathway |
| GO:1902287 | semaphorin-plexin signaling pathway involved in axon guidance |
| GO:0007416 | synapse assembly |
| InterPro ID | InterPro Term |
|---|---|
| IPR013783 | Ig-like_fold |
| IPR014756 | Ig_E-set |
| IPR002909 | IPT_dom |
| IPR031148 | Plexin |
| IPR013548 | Plexin_cytoplasmic_RasGAP_dom |
| IPR002165 | Plexin_repeat |
| IPR016201 | PSI |
| IPR008936 | Rho_GTPase_activation_prot |
| IPR001627 | Semap_dom |
| IPR036352 | Semap_dom_sf |
| IPR041019 | TIG1_plexin |
| IPR015943 | WD40/YVTN_repeat-like_dom_sf |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51004 | SEMA |