| Tag | Content |
|---|---|
| Uniprot ID | H2QNC7 |
| Entrez ID | 460687 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_009446434.2 |
| Ensembl protein ID | ENSPTRP00000026498 |
| Ensembl nucleotide ID | ENSPTRG00000015381 |
| Gene name | Plexin D1 |
| Gene symbol | PLXND1 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MAPRAAGGAP LSARAAAASP PPFQTPPRCP VPLLLLLLLG AARAGALEIQ RRFPSPTPTN 60 NFALDGAAGT VYLAAVNRLY QLSGANLSLE AEAAVGPVPD SPLCHAPQLP QASCEHPRRL 120 TDNYNKILQL DPGQGLVVVC GSIYQGFCQL RRRGNISAVA VRFPPAAPPA EPVTVFPSML 180 NVAANHPNAS TVGLVLPPAA GAGGSRLLVG ATYTGYGSSF FPRNRSLEDH RFENTPEIAI 240 RSLDTRGDLA KLFTFDLNPS DDNILKIKQG AKEQHKLGFV SAFLHPSDPP PGAQSYAYLA 300 LNSEARAGDK ESQARSLLAR ICLPHGAGGD AKKLTESYIQ LGLQCAGGAG RGDLYSRLVS 360 VFPARERLFA VFERPQGSPA ARAAPAALCA FRFADVRAAI RAARTACFVE PAPDVVAVLD 420 SVVQGTGPAC ERKLNIQLQP EQLDCGAAHL QHPLSILQPL KATPVFRAPG LTSVAVASVN 480 NYTAVFLGTV NGRLLKINLN ESMQVVSRRV VTVAYGEPVH HVMQFDPADS GYLYLMTSHQ 540 MARVKVAACN VHSTCGDCVG AADAYCGWCA LETRCTLQQD CANSSQQHFW TSASEGPSRC 600 PAMTVLPAEI DVRQEYPGMI LQILGSLPSL SGMEMACDYG NNIRTVARVP GPAFGHQIAY 660 CNLLPRDQFP PFPPNQDHVT VEMFVRVNRR NIVKANFTIY DCSRTAQVYP HTACTSCLSA 720 QWPCFWCSQQ HSCVSNQSQC EASPNPTSPQ DCPRTLLSPL APVPTGGSQN ILVPLANTAF 780 FQGAALECSF GLEEIFEAVW VNESVVRCDQ VVLHTTRKSQ VFPLSLQLKG RPARFLDSPE 840 PMTVMVYNCA MGSPDCSQCL GREDLGHLCV WSDGCRLRGP LQPMAGTCPA PEIRAIEPLS 900 GPLDGGTLLT IRGRNLGRRL SDVAHGVWIG GVPCEPLPDR YTVSEEIVCV TGPAPGPLSG 960 VVTVNASKEG KSRDRFSYVL PLVHSLEPTM GPKAGGTRIT IHGNDLHVGS ELQVLVNDTD 1020 PCTELMRTDT SIACTMPEGA LPAPVPVCVR FERRGCVHGN LTFWYMQNPV IMAISPRRSP 1080 VSGGRTITVA GERFHMVQNV SMAVHHIGRE PTLCKVLNST LITCPSPGAL SNASAPVDFF 1140 INGRAYADEV AVAEELLDPE EAQRGSRFRL DYLPNPQFST AKREKWIKHH PGEPLTLVIH 1200 KEQDSLGLQS HEYRVKIGQV SCDIQIVSDR IIHCSVNESL GAAEGQLPIT IQVGNFNQTI 1260 ATLQLGGSET AIIVSIVICS VLLLLSVVAL FVFCTKSRRA ERYWQKTLLQ MEEMESQIRE 1320 EIRKGFAELQ TDMTDLTKEL NRSQGIPFLE YKHFVTRTFF PKCSSLYEER YVLPSQTLNS 1380 QGSSQAQETH PLLGEWKIPE SCRPNMEEGI SLFSSLLNNK HFLIVFVHAL EQQKDFAVRD 1440 RCSLASLLTI ALHGKLEYYT SIMKELLVDL IDASAAKNPK LMLRRTESVV EKMLTNWMSI 1500 CMYSCLRETV GEPFFLLLCA IKQQINKGSI DAITGKARYT LNEEWLLREN IEAKPRNLNV 1560 SFQGCGMDSL SVRAMDTDTL TQVKEKILEA FCKNVPYSQW PRAEDVDLEW FASSTQSYIL 1620 RDLDDTSVVE DGRKKLNTLA HYKIPEGASL AMSLIDKKDN TLGRVKDLDT EKYFHLVLPT 1680 DELAEPKKSH RQSHRKKVLP EIYLTRLLST KGTLQKFLDD LFKAILSIRE DKPPLAVKYF 1740 FDFLEEQAEK RGISDPDTLH IWKTNSLPLR FWVNILKNPQ FVFDIDKTDH IDACLSVIAQ 1800 AFIDACSISD LQLGKDSPTN KLLYAKEIPE YRKIVQRYYK QIQDMTPLSE QEMNAHLAEE 1860 SRKYQNEFNT NVAMAEIYKY AKRYRPQIMA ALEANPTARR TQLQHKFEQV VALMEDNIYE 1920 CYSEA 1925 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PLXND1 | E2RDE1 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | PLXND1 | A0A452DYE9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PLXND1 | 23129 | Q9Y4D7 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Plxnd1 | 67784 | Q3UH93 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PLXND1 | 460687 | H2QNC7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Plxnd1 | 312652 | D4AA77 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005887 | integral component of plasma membrane |
| GO:0030027 | lamellipodium |
| GO:0002116 | semaphorin receptor complex |
| GO:0019904 | protein domain specific binding |
| GO:0017154 | semaphorin receptor activity |
| GO:0035904 | aorta development |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0003279 | cardiac septum development |
| GO:0060976 | coronary vasculature development |
| GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching |
| GO:0043542 | endothelial cell migration |
| GO:0007162 | negative regulation of cell adhesion |
| GO:0003151 | outflow tract morphogenesis |
| GO:0050772 | positive regulation of axonogenesis |
| GO:0032092 | positive regulation of protein binding |
| GO:0045765 | regulation of angiogenesis |
| GO:0030334 | regulation of cell migration |
| GO:0008360 | regulation of cell shape |
| GO:0043087 | regulation of GTPase activity |
| GO:1902287 | semaphorin-plexin signaling pathway involved in axon guidance |
| GO:0007416 | synapse assembly |
| InterPro ID | InterPro Term |
|---|---|
| IPR013783 | Ig-like_fold |
| IPR014756 | Ig_E-set |
| IPR002909 | IPT_dom |
| IPR031148 | Plexin |
| IPR042719 | Plexin-D1_Sema |
| IPR013548 | Plexin_cytoplasmic_RasGAP_dom |
| IPR002165 | Plexin_repeat |
| IPR016201 | PSI |
| IPR008936 | Rho_GTPase_activation_prot |
| IPR001627 | Semap_dom |
| IPR036352 | Semap_dom_sf |
| IPR041019 | TIG1_plexin |
| IPR015943 | WD40/YVTN_repeat-like_dom_sf |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51004 | SEMA |