| Tag | Content |
|---|---|
| Uniprot ID | A0A452E8G0 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000008226 |
| Ensembl nucleotide ID | ENSCHIG00000011473 |
| Gene name | Serine/threonine-protein kinase receptor |
| Gene symbol | TGFBR2 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGRGLLGGLW PLHVVLWTRI ASTIPPHVPK SVNSDLMVTD HNGAIKLSQL CKFCDVRSST 60 CDNQKSCWSN CSITAICEKP EEVCVAVWRK NDENITLETV CHDPKIAYHG FVLDDAASPK 120 CIMKERKGSG ETFFMCSCSA EECNDHIIFS EEYTSSNPDL LLVIFQVTGV SLLPPLGIAI 180 AVIVIFYCYR IHRQQKLSPA WDSGKPRKLM EFSEHLAIIL EDDRSDISST CANNINHNTE 240 LLPIELDTLV GKGRFAEVYK IFPYEEYASW KTEKDIFSDI NLKHENILQF LTAEERKTEL 300 GKQYWLITAF HAKGNLQEYL TRHVISWEDL RRLGGSLARG IAHLHSDHTL CGRPKMPIVH 360 RDLKSSNILV KGDLTCCLCD FGLSLRLDPT LSVDDLANSG QVGTARYMAP EVLESRMNLE 420 NVESFKQTDV YSMALVLWEM TSRCNAVGEV KDYEPPFGSK VREHPCVESM KDSVLRDRGR 480 PEIPSSWLNH QGIQMVCETL AECWDHDPEA RLTAQCVAER FSELEHLDRL SGRSSSEEKI 540 PEDGSLNTTK |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TGFBR2 | 477039 | A0A5F4D8G5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | TGFBR2 | A0A452E8G0 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TGFBR2 | 7048 | P37173 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tgfbr2 | 21813 | Q62312 | CPO | E14.0, E15.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | TGFBR2 | 460243 | H2QZF5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TGFBR2_tv2 | A0A5K1VMN1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TGFBR2 | G1TAL4 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Tgfbr2 | 81810 | P38438 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tgfbr2b | F1QKF4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005901 | caveola |
| GO:0009897 | external side of plasma membrane |
| GO:0016021 | integral component of membrane |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0005539 | glycosaminoglycan binding |
| GO:0046872 | metal ion binding |
| GO:0046332 | SMAD binding |
| GO:0050431 | transforming growth factor beta binding |
| GO:0005026 | transforming growth factor beta receptor activity, type II |
| GO:0034713 | type I transforming growth factor beta receptor binding |
| GO:0032147 | activation of protein kinase activity |
| GO:0007420 | brain development |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0060434 | bronchus morphogenesis |
| GO:0003214 | cardiac left ventricle morphogenesis |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0035162 | embryonic hemopoiesis |
| GO:0003274 | endocardial cushion fusion |
| GO:0007369 | gastrulation |
| GO:0003430 | growth plate cartilage chondrocyte growth |
| GO:0001947 | heart looping |
| GO:0001701 | in utero embryonic development |
| GO:1905317 | inferior endocardial cushion morphogenesis |
| GO:0002088 | lens development in camera-type eye |
| GO:1990086 | lens fiber cell apoptotic process |
| GO:0060463 | lung lobe morphogenesis |
| GO:0060443 | mammary gland morphogenesis |
| GO:0003149 | membranous septum morphogenesis |
| GO:1990428 | miRNA transport |
| GO:0043011 | myeloid dendritic cell differentiation |
| GO:0007219 | Notch signaling pathway |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0060389 | pathway-restricted SMAD protein phosphorylation |
| GO:0018105 | peptidyl-serine phosphorylation |
| GO:0018107 | peptidyl-threonine phosphorylation |
| GO:0045766 | positive regulation of angiogenesis |
| GO:0002663 | positive regulation of B cell tolerance induction |
| GO:2000563 | positive regulation of CD4-positive, alpha-beta T cell proliferation |
| GO:0010634 | positive regulation of epithelial cell migration |
| GO:1905007 | positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:0051138 | positive regulation of NK T cell differentiation |
| GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| GO:0002666 | positive regulation of T cell tolerance induction |
| GO:0002651 | positive regulation of tolerance induction to self antigen |
| GO:0010468 | regulation of gene expression |
| GO:0070723 | response to cholesterol |
| GO:0042493 | response to drug |
| GO:0062009 | secondary palate development |
| GO:0007224 | smoothened signaling pathway |
| GO:0060440 | trachea formation |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| GO:0003186 | tricuspid valve morphogenesis |
| GO:0001570 | vasculogenesis |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1015 | Disulfide bond |
| KW-0418 | Kinase |
| KW-0460 | Magnesium |
| KW-0464 | Manganese |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0723 | Serine/threonine-protein kinase |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |