| Tag | Content |
|---|---|
| Uniprot ID | P38438 |
| Entrez ID | 81810 |
| Genbank protein ID | AAA42237.1; AAB29352.2; |
| Genbank nucleotide ID | NM_031132.3 |
| Ensembl protein ID | ENSRNOP00000035501 |
| Ensembl nucleotide ID | ENSRNOG00000013265 |
| Gene name | TGF-beta receptor type-2 |
| Gene symbol | Tgfbr2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity). |
| Sequence | MGRGLLRGLW PLHIVLWTRI ASTIPPHVPK SVNSDLMAGD NSGAVKLPQL CKFCDVTLST 60 CDNQKSCMSN CSVTSICEKP QEVCVAVWRK NDKNITLETV CHDPKFTYHG FTLEDATSPT 120 CVMKEKKRAG ETFFMCSCNT EECNDYIIFN EEYTTSSPDL LLVIIQVTGV SLLPPLGIAI 180 AVIAIFYCYR VHRQQKLSPS WESSKPRKLM DFSDNCAIIL EDDRSDISST CANNINHNTE 240 LLPIELDTLV GKGRFAEVYK AKLKQNTSEQ FETVAVKIFP YEEYSSWKTE KDIFSDINLK 300 HENILQFLTA EERKTEMGKQ YWLITAFHAK GNLQEYLTRH VISWEDLRKL GSSLARGIAH 360 LHSDHTPCGR PKMPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPTLSV DDLANSGQVG 420 TARYMAPEVL ESRMNLENME SFKQTDVYSM ALVLWEMTSR CNAVGEVKDY EPPFGSKVRE 480 HPCVESMKDN VLRDRGRPEI PSFWLNHQGI QIVCETLTEC WDHDPEARLT AQCVAERFSE 540 LEHPDRLSGR SCSQEKIPED GSLNTTK 567 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TGFBR2 | 477039 | A0A5F4D8G5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | TGFBR2 | A0A452E8G0 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TGFBR2 | 7048 | P37173 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tgfbr2 | 21813 | Q62312 | CPO | E14.0, E15.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | TGFBR2 | 460243 | H2QZF5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TGFBR2_tv2 | A0A5K1VMN1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TGFBR2 | G1TAL4 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Tgfbr2 | 81810 | P38438 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tgfbr2b | F1QKF4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005901 | caveola |
| GO:0009986 | cell surface |
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0009897 | external side of plasma membrane |
| GO:0016021 | integral component of membrane |
| GO:0005887 | integral component of plasma membrane |
| GO:0045121 | membrane raft |
| GO:0005886 | plasma membrane |
| GO:0043235 | receptor complex |
| GO:0048185 | activin binding |
| GO:0017002 | activin-activated receptor activity |
| GO:0005524 | ATP binding |
| GO:0005539 | glycosaminoglycan binding |
| GO:0046872 | metal ion binding |
| GO:0031435 | mitogen-activated protein kinase kinase kinase binding |
| GO:0042803 | protein homodimerization activity |
| GO:0004674 | protein serine/threonine kinase activity |
| GO:0044877 | protein-containing complex binding |
| GO:0046332 | SMAD binding |
| GO:0050431 | transforming growth factor beta binding |
| GO:0005026 | transforming growth factor beta receptor activity, type II |
| GO:0005024 | transforming growth factor beta-activated receptor activity |
| GO:0004675 | transmembrane receptor protein serine/threonine kinase activity |
| GO:0034713 | type I transforming growth factor beta receptor binding |
| GO:0034714 | type III transforming growth factor beta receptor binding |
| GO:0032147 | activation of protein kinase activity |
| GO:0007568 | aging |
| GO:0009887 | animal organ morphogenesis |
| GO:0031100 | animal organ regeneration |
| GO:0006915 | apoptotic process |
| GO:0003181 | atrioventricular valve morphogenesis |
| GO:0007420 | brain development |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0060433 | bronchus development |
| GO:0060434 | bronchus morphogenesis |
| GO:0003214 | cardiac left ventricle morphogenesis |
| GO:0051216 | cartilage development |
| GO:0071363 | cellular response to growth factor stimulus |
| GO:0007182 | common-partner SMAD protein phosphorylation |
| GO:0048565 | digestive tract development |
| GO:0007566 | embryo implantation |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0035162 | embryonic hemopoiesis |
| GO:0003274 | endocardial cushion fusion |
| GO:0007369 | gastrulation |
| GO:0003430 | growth plate cartilage chondrocyte growth |
| GO:0003417 | growth plate cartilage development |
| GO:0007507 | heart development |
| GO:0001947 | heart looping |
| GO:0001701 | in utero embryonic development |
| GO:1905317 | inferior endocardial cushion morphogenesis |
| GO:0002088 | lens development in camera-type eye |
| GO:1990086 | lens fiber cell apoptotic process |
| GO:0030324 | lung development |
| GO:0060463 | lung lobe morphogenesis |
| GO:0060425 | lung morphogenesis |
| GO:0060443 | mammary gland morphogenesis |
| GO:0003149 | membranous septum morphogenesis |
| GO:1990428 | miRNA transport |
| GO:0043011 | myeloid dendritic cell differentiation |
| GO:0060044 | negative regulation of cardiac muscle cell proliferation |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0007219 | Notch signaling pathway |
| GO:0003151 | outflow tract morphogenesis |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0060389 | pathway-restricted SMAD protein phosphorylation |
| GO:0018105 | peptidyl-serine phosphorylation |
| GO:0018107 | peptidyl-threonine phosphorylation |
| GO:0045766 | positive regulation of angiogenesis |
| GO:0002663 | positive regulation of B cell tolerance induction |
| GO:2000563 | positive regulation of CD4-positive, alpha-beta T cell proliferation |
| GO:0010634 | positive regulation of epithelial cell migration |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:1905007 | positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:0051138 | positive regulation of NK T cell differentiation |
| GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| GO:0043415 | positive regulation of skeletal muscle tissue regeneration |
| GO:0048661 | positive regulation of smooth muscle cell proliferation |
| GO:0002666 | positive regulation of T cell tolerance induction |
| GO:0002651 | positive regulation of tolerance induction to self antigen |
| GO:0006468 | protein phosphorylation |
| GO:0006898 | receptor-mediated endocytosis |
| GO:0042127 | regulation of cell population proliferation |
| GO:0010468 | regulation of gene expression |
| GO:0070723 | response to cholesterol |
| GO:0042493 | response to drug |
| GO:0043627 | response to estrogen |
| GO:0009749 | response to glucose |
| GO:0001666 | response to hypoxia |
| GO:0009612 | response to mechanical stimulus |
| GO:0007584 | response to nutrient |
| GO:0014070 | response to organic cyclic compound |
| GO:0010033 | response to organic substance |
| GO:0048545 | response to steroid hormone |
| GO:0062009 | secondary palate development |
| GO:0007224 | smoothened signaling pathway |
| GO:0060440 | trachea formation |
| GO:0060439 | trachea morphogenesis |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| GO:0003186 | tricuspid valve morphogenesis |
| GO:0001570 | vasculogenesis |
| GO:0060412 | ventricular septum morphogenesis |
| GO:0042060 | wound healing |
| Keyword ID | Keyword Term |
|---|---|
| KW-0053 | Apoptosis |
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0221 | Differentiation |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0341 | Growth regulation |
| KW-0418 | Kinase |
| KW-0460 | Magnesium |
| KW-0464 | Manganese |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0723 | Serine/threonine-protein kinase |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |