| Tag | Content |
|---|---|
| Uniprot ID | F1QKF4 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000039831 |
| Ensembl nucleotide ID | ENSDARG00000034541 |
| Gene name | TGF-beta receptor type-2 |
| Gene symbol | tgfbr2b |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. |
| Sequence | MERYQLSVLC WWTFLISTVV DWRGVDGNNP FYRPYRIPQL CKFCDVLESN CNGKDTCESN 60 CSITSICESP DEICVAIWRQ SDDNNTIETL CHNPTVPLYG IMVENNNNTK CEMKKRISNS 120 GPFHICSCNE VECNDMLLFK LPTNNQVVLV ILVSLLPLLV LAVLVIASFY WYRMYRRRKL 180 DEWETKKPSK HKGPKGPLDC SDACAIMMDD DRSDSSSTHA NNINHNMDPL PIELDLQVGK 240 GRFAEVYKAK LRQSPSEQFE TVAVKIFPYE EYASWKNEKD IFQDIDLKHE NILHFLTAEE 300 RKVEKQYWLI TAFHPRGNLQ EYLMRHLLSW EDLRLLGSSL ASGVAHLHSD HTPCGRPKVP 360 IVHRDLKSSN ILVKNDLTCC LCDFGLGLRL DNSLSVDELA NSGQVGTARY MAPEVLESRI 420 NLENIESFKQ TDVYSMALVL WEITSRCNAI GEVKDYEPPF GSKVREHPCV ESMKDNVLRD 480 RGRPEIPSSW MKHQGVAAVC ATINECWDHD PEARLTAQCV AERFNEMDDD LDKLSTCSSS 540 EEKIPEDCAV SVSDDK 556 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TGFBR2 | 477039 | A0A5F4D8G5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | TGFBR2 | A0A452E8G0 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TGFBR2 | 7048 | P37173 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tgfbr2 | 21813 | Q62312 | CPO | E14.0, E15.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | TGFBR2 | 460243 | H2QZF5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TGFBR2_tv2 | A0A5K1VMN1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TGFBR2 | G1TAL4 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Tgfbr2 | 81810 | P38438 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tgfbr2b | F1QKF4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0045121 | membrane raft |
| GO:0005886 | plasma membrane |
| GO:0043235 | receptor complex |
| GO:0048185 | activin binding |
| GO:0017002 | activin-activated receptor activity |
| GO:0005524 | ATP binding |
| GO:0046872 | metal ion binding |
| GO:0004674 | protein serine/threonine kinase activity |
| GO:0046332 | SMAD binding |
| GO:0050431 | transforming growth factor beta binding |
| GO:0005026 | transforming growth factor beta receptor activity, type II |
| GO:0005024 | transforming growth factor beta-activated receptor activity |
| GO:0034713 | type I transforming growth factor beta receptor binding |
| GO:0006915 | apoptotic process |
| GO:0071363 | cellular response to growth factor stimulus |
| GO:0007507 | heart development |
| GO:0060218 | hematopoietic stem cell differentiation |
| GO:0006468 | protein phosphorylation |
| GO:0040008 | regulation of growth |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-0053 | Apoptosis |
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0221 | Differentiation |
| KW-1015 | Disulfide bond |
| KW-0341 | Growth regulation |
| KW-0418 | Kinase |
| KW-0460 | Magnesium |
| KW-0464 | Manganese |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0723 | Serine/threonine-protein kinase |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |