Gene: TGFBR2

Basic information

Tag Content
Uniprot ID A0A5F4D8G5
Entrez ID 477039
Genbank protein ID
Genbank nucleotide ID XM_005634331.2
Ensembl protein ID ENSCAFP00000063016
Ensembl nucleotide ID ENSCAFG00000005449
Gene name TGF-beta receptor type-2
Gene symbol TGFBR2
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
Sequence
MMCHVTPSYA ERSCPCSLPL VNDFLVNNDM MVTDSNGVIK FPQLCKFCDV RSSTCDNQKS 60
CMSNCSITSI CEKPHEVCLA VWRKNDENIT LETLCHDPKD TYHGIVLEDA ASSKCIMKEK 120
KVLGETFFMC SCSSDECNDY IIFSEEYATN NPDLLLVIFQ VTGVSLLPPL GIAIAVIVTF 180
YCYRVHRQQK LSPSWETSKP RKLMEFSEHL AIILEDDRSD ISSTCANNIN HNTELLPIEL 240
DTLVGKGRFA EVYKAKLKQN TSEQFETVAV KIFPYEEYAS WKTEKDIFSD INLKHENILQ 300
FLTAEERKTE LGKQYWLITA FHAKGNLQEY LTRHVISWED LRKLGSSLAR GIAHLHSDHT 360
LCGRPKMPIV HRDLKSSNIL VKNDLTCCLC DFGLSLRLDP TLSVDDLANS GQVGTARYMA 420
PEVLESRMNL ENVESFKQTD VYSMALVLWE MTSRCNAVGE VKDYEPPFGS KVREHPCVES 480
MKDNVLRDRG RPEIPSSWLN HQGIQMVCET LTECWDHDPE ARLTAQCVAE RFSELEHLDR 540
LSGRSCSEEK IPEDGSLNTT K 561

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTGFBR2477039A0A5F4D8G5Canis lupus familiarisPredictionMore>>
1:1 orthologTGFBR2A0A452E8G0Capra hircusPredictionMore>>
1:1 orthologTGFBR27048P37173Homo sapiensPredictionMore>>
1:1 orthologTgfbr221813Q62312CPOE14.0, E15.5Mus musculusPublicationMore>>
1:1 orthologTGFBR2460243H2QZF5Pan troglodytesPredictionMore>>
1:1 orthologTGFBR2_tv2A0A5K1VMN1Sus scrofaPredictionMore>>
1:1 orthologTGFBR2G1TAL4Oryctolagus cuniculusPredictionMore>>
1:1 orthologTgfbr281810P38438Rattus norvegicusPredictionMore>>
1:1 orthologtgfbr2bF1QKF4Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0016021 integral component of membrane
GO:0005886 plasma membrane
GO:0043235 receptor complex
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0005026 transforming growth factor beta receptor activity, type II
GO:0006915 apoptotic process
GO:0030154 cell differentiation
GO:0040008 regulation of growth
GO:0007179 transforming growth factor beta receptor signaling pathway

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0053 Apoptosis
KW-0067 ATP-binding
KW-1003 Cell membrane
KW-0221 Differentiation
KW-1015 Disulfide bond
KW-0341 Growth regulation
KW-0418 Kinase
KW-0460 Magnesium
KW-0464 Manganese
KW-0472 Membrane
KW-0479 Metal-binding
KW-0547 Nucleotide-binding
KW-0675 Receptor
KW-1185 Reference proteome
KW-0723 Serine/threonine-protein kinase
KW-0808 Transferase
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
IPR017194 Transform_growth_fac-b_typ-2
IPR015013 Transforming_GF_b_rcpt_2_ecto

PROSITE

PROSITE ID PROSITE Term
PS00107 PROTEIN_KINASE_ATP
PS50011 PROTEIN_KINASE_DOM
PS00108 PROTEIN_KINASE_ST

Pfam

Pfam ID Pfam Term
PF08917 ecTbetaR2
PF07714 Pkinase_Tyr