| Tag | Content |
|---|---|
| Uniprot ID | A0A5F4D8G5 |
| Entrez ID | 477039 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005634331.2 |
| Ensembl protein ID | ENSCAFP00000063016 |
| Ensembl nucleotide ID | ENSCAFG00000005449 |
| Gene name | TGF-beta receptor type-2 |
| Gene symbol | TGFBR2 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. |
| Sequence | MMCHVTPSYA ERSCPCSLPL VNDFLVNNDM MVTDSNGVIK FPQLCKFCDV RSSTCDNQKS 60 CMSNCSITSI CEKPHEVCLA VWRKNDENIT LETLCHDPKD TYHGIVLEDA ASSKCIMKEK 120 KVLGETFFMC SCSSDECNDY IIFSEEYATN NPDLLLVIFQ VTGVSLLPPL GIAIAVIVTF 180 YCYRVHRQQK LSPSWETSKP RKLMEFSEHL AIILEDDRSD ISSTCANNIN HNTELLPIEL 240 DTLVGKGRFA EVYKAKLKQN TSEQFETVAV KIFPYEEYAS WKTEKDIFSD INLKHENILQ 300 FLTAEERKTE LGKQYWLITA FHAKGNLQEY LTRHVISWED LRKLGSSLAR GIAHLHSDHT 360 LCGRPKMPIV HRDLKSSNIL VKNDLTCCLC DFGLSLRLDP TLSVDDLANS GQVGTARYMA 420 PEVLESRMNL ENVESFKQTD VYSMALVLWE MTSRCNAVGE VKDYEPPFGS KVREHPCVES 480 MKDNVLRDRG RPEIPSSWLN HQGIQMVCET LTECWDHDPE ARLTAQCVAE RFSELEHLDR 540 LSGRSCSEEK IPEDGSLNTT K 561 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TGFBR2 | 477039 | A0A5F4D8G5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | TGFBR2 | A0A452E8G0 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TGFBR2 | 7048 | P37173 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Tgfbr2 | 21813 | Q62312 | CPO | E14.0, E15.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | TGFBR2 | 460243 | H2QZF5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TGFBR2_tv2 | A0A5K1VMN1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TGFBR2 | G1TAL4 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Tgfbr2 | 81810 | P38438 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | tgfbr2b | F1QKF4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0046872 | metal ion binding |
| GO:0005026 | transforming growth factor beta receptor activity, type II |
| GO:0006915 | apoptotic process |
| GO:0030154 | cell differentiation |
| GO:0040008 | regulation of growth |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-0053 | Apoptosis |
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0221 | Differentiation |
| KW-1015 | Disulfide bond |
| KW-0341 | Growth regulation |
| KW-0418 | Kinase |
| KW-0460 | Magnesium |
| KW-0464 | Manganese |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0723 | Serine/threonine-protein kinase |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |