| Tag | Content |
|---|---|
| Uniprot ID | A0A452EW38 |
| Entrez ID | 102179616 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018059293.1 |
| Ensembl protein ID | ENSCHIP00000016239 |
| Ensembl nucleotide ID | ENSCHIG00000016564 |
| Gene name | Hedgehog protein |
| Gene symbol | IHH |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Intercellular signal essential for a variety of patterning events during development. |
| Sequence | MSPARLRPRL RFCLLLLLLL VPAARGCGPG RVVGSRRRPP RKLVPLAYKQ FSPNVPEKTL 60 GASGRYEGKI ARSSERFKEL TPNYNPDIIF KDEENTGADR LMTQRCKDRL NSLAISVMNQ 120 WPGVKLRVTE GWDEDGHHSE ESLHYEGRAV DITTSDRDRN KYGLLARLAV EAGFDWVYYE 180 SKAHVHCSVK SEHSAAAKTG GCFPAGAQVR LESGARVALS AVRPGDRVLA MGEDGNPTFS 240 DVLIFLDREP DRLRAFQVIE TQDPPRRLAL TPAHLLFTAN NHTEPAAHFR ATFASQVQPG 300 QYVLVAGVPG LQPARVAAVS THVALGAYAP LTRHGTLVVE DVVASCFAAV ADHHLAQLAF 360 WPLRLFHSLA WGSWTPGEGV HWYPQLLYRL GRLLLEEGSF HSLGVAGAGS |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | IHH | 102179616 | A0A452EW38 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | IHH | 3549 | Q14623 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ihh | 16147 | P97812 | CLP | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | IHH | 470652 | H2QJG1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | IHH | 100008942 | G1U6S4 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Ihh | 84399 | F1LP42 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ihha | B0S8K0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0005886 | plasma membrane |
| GO:0005509 | calcium ion binding |
| GO:0005113 | patched binding |
| GO:0008233 | peptidase activity |
| GO:0045453 | bone resorption |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0060220 | camera-type eye photoreceptor cell fate commitment |
| GO:0001708 | cell fate specification |
| GO:0048469 | cell maturation |
| GO:0007267 | cell-cell signaling |
| GO:0003413 | chondrocyte differentiation involved in endochondral bone morphogenesis |
| GO:0035988 | chondrocyte proliferation |
| GO:0048596 | embryonic camera-type eye morphogenesis |
| GO:0048557 | embryonic digestive tract morphogenesis |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0009880 | embryonic pattern specification |
| GO:0072498 | embryonic skeletal joint development |
| GO:0003382 | epithelial cell morphogenesis |
| GO:0090136 | epithelial cell-cell adhesion |
| GO:0060323 | head morphogenesis |
| GO:0001947 | heart looping |
| GO:0001701 | in utero embryonic development |
| GO:0016539 | intein-mediated protein splicing |
| GO:0035264 | multicellular organism growth |
| GO:0046639 | negative regulation of alpha-beta T cell differentiation |
| GO:0048074 | negative regulation of eye pigmentation |
| GO:0033088 | negative regulation of immature T cell proliferation in thymus |
| GO:0048666 | neuron development |
| GO:0001649 | osteoblast differentiation |
| GO:0031016 | pancreas development |
| GO:0046638 | positive regulation of alpha-beta T cell differentiation |
| GO:0032967 | positive regulation of collagen biosynthetic process |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:0045880 | positive regulation of smoothened signaling pathway |
| GO:0033089 | positive regulation of T cell differentiation in thymus |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0016540 | protein autoprocessing |
| GO:0006029 | proteoglycan metabolic process |
| GO:0040008 | regulation of growth |
| GO:0003406 | retinal pigment epithelium development |
| GO:0048745 | smooth muscle tissue development |
| GO:0007224 | smoothened signaling pathway |
| GO:0061053 | somite development |
| GO:0030704 | vitelline membrane formation |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50817 | INTEIN_N_TER |